1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Ro 04-6790

Ro 04-6790 

Cat. No.: HY-14335
Handling Instructions

Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors.

For research use only. We do not sell to patients.

Ro 04-6790 Chemical Structure

Ro 04-6790 Chemical Structure

CAS No. : 202466-68-0

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Description

Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].

IC50 & Target[1]

Rat 5-HT6 Receptor

7.26 (pKi)

Human 5-HT6 Receptor

7.35 (pKi)

In Vitro

Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1].

In Vivo

Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].

Molecular Weight

308.36

Formula

C₁₂H₁₆N₆O₂S

CAS No.

202466-68-0

SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC(NC)=NC(NC)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Ro 04-67905-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Ro 04-6790
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