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Cat. No.: HY-153241

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GSK737

Customer Review

Based on 1 Customer Validation

GSK737 is a BRD4 BD1 and BD2 inhibitor, with pIC₅₀ values of 5.3 and 7.3 respectively. GSK737 has low clearance and good solubility and permeability in rat.

For research use only. We do not sell to patients.

Purity: 99.89%

CAS No.: 2748687-95-6

Formula: C₂₀H₂₁N₅O₂

Molecular Weight:363.41

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (271 KB)

SDS

COA

GSK737 Chemical Structure

CAS No.: 2748687-95-6

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Data Download

Data Sheet (271 KB)

SDS

COA

Handling Instructions (2659 KB)

To place orders, for customer services and technical support, please contact:

609-228-6898

[email protected] [email protected]

Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

All Epigenetic Reader Domain Isoforms
More

Brd

BRPF1

BRPF2

BRPF3

BRD2

BRD3

BRD4

BRDT

CECR2

BD1

BD2

BRD7

BRD9

BET

BAZ

Biological Activity

Description

Chemical Information

Solvent & Solubility

In Vitro

Purity & Documentation

References

Help & FAQs

Classifications

Bioz

Biological Activity

Description

GSK737 is a BRD4 BD1 and BD2 inhibitor, with pIC₅₀ values of 5.3 and 7.3 respectively. GSK737 has low clearance and good solubility and permeability in rat^[1].

All Epigenetic Reader Domain Isoforms :

Brd

BRPF1

BRPF2

BRPF3

BRD2

BRD3

BRD4

BRDT

CECR2

BD1

BD2

BRD7

BRD9

BET

BAZ

Chemical Information

CAS No. 2748687-95-6

Appearance Solid

Molecular Weight 363.41

Formula C₂₀H₂₁N₅O₂

Color White to light yellow

SMILES

C[C@@H](C1=CC=CC=N1)OC2=C(C3=CN(C)N=N3)C=C(C=C2)C(NC4CC4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (275.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7517 mL

13.7586 mL

27.5171 mL

5 mM

0.5503 mL

2.7517 mL

5.5034 mL

10 mM

0.2752 mL

1.3759 mL

2.7517 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)

SDS (251 KB)

English - EN (251 KB)

Français - FR (251 KB)

Deutsch - DE (251 KB)

Norwegian - NO (251 KB)

Español - ES (251 KB)

Swedish - SV (251 KB)

Italian - IT (251 KB)

Korean - KR (251 KB)

Portuguese - PT (251 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Aylott HE, et al. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J Med Chem. 2021 Mar 25;64(6):3249-3281. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.7517 mL 13.7586 mL 27.5171 mL 68.7928 mL

5 mM 0.5503 mL 2.7517 mL 5.5034 mL 13.7586 mL

10 mM 0.2752 mL 1.3759 mL 2.7517 mL 6.8793 mL

15 mM 0.1834 mL 0.9172 mL 1.8345 mL 4.5862 mL

20 mM 0.1376 mL 0.6879 mL 1.3759 mL 3.4396 mL

25 mM 0.1101 mL 0.5503 mL 1.1007 mL 2.7517 mL

30 mM 0.0917 mL 0.4586 mL 0.9172 mL 2.2931 mL

40 mM 0.0688 mL 0.3440 mL 0.6879 mL 1.7198 mL

50 mM 0.0550 mL 0.2752 mL 0.5503 mL 1.3759 mL

60 mM 0.0459 mL 0.2293 mL 0.4586 mL 1.1465 mL

80 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8599 mL

100 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.6879 mL

GSK737 Related Classifications

HY-153241 Related Classifications

Epigenetics

Epigenetic Reader Domain

Disease Areas

Cancer Blood or Cardio-cerebrovascular Disease

Leukemia/Lymphoma/Myeloma Blood Disease

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Powered by Bioz See more details on Bioz

Keywords

GSK737
2748687-95-6
GSK 737
GSK-737
Epigenetic Reader Domain
BET
rat
low clearance
Inhibitor
inhibitor
inhibit

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Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7517 mL	13.7586 mL	27.5171 mL	68.7928 mL
5 mM	0.5503 mL	2.7517 mL	5.5034 mL	13.7586 mL
10 mM	0.2752 mL	1.3759 mL	2.7517 mL	6.8793 mL
15 mM	0.1834 mL	0.9172 mL	1.8345 mL	4.5862 mL
20 mM	0.1376 mL	0.6879 mL	1.3759 mL	3.4396 mL
25 mM	0.1101 mL	0.5503 mL	1.1007 mL	2.7517 mL
30 mM	0.0917 mL	0.4586 mL	0.9172 mL	2.2931 mL
40 mM	0.0688 mL	0.3440 mL	0.6879 mL	1.7198 mL
50 mM	0.0550 mL	0.2752 mL	0.5503 mL	1.3759 mL
60 mM	0.0459 mL	0.2293 mL	0.4586 mL	1.1465 mL
80 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8599 mL
100 mM	0.0275 mL	0.1376 mL	0.2752 mL	0.6879 mL

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Biological Activity

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