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Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .
ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells .
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM. REV7/REV3L-IN-1 binds directly to REV7 and inhibits its interaction with REV3L. REV7/REV3L-IN-1 inhibits interstrand crosslink repair in cells. REV7/REV3L-IN-1 chemosensitizes cancer cells to Cisplatin (HY-17394). REV7/REV3L-IN-1 can be used in cervical cancer research .
PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
Myelin basic protein, MBP (68-86) is the portion of the 68th to 86th amino acid residues in the MBP protein sequence. Myelin basic protein, MBP (68-86) can act as an autoantigen, triggering the immune system to attack its own myelin. Myelin basic protein, MBP (68-86) is used as one of the immunogens in the experimental autoimmune encephalomyelitis (EAE) animal model to study immune responses associated with multiple sclerosis (MS) .
ZYF0033 is an orally active inhibitor of the hematopoietic progenitor cell kinase HPK1 with an IC50 of less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 promotes anti-cancer immune responses and reduces phosphorylation of SLP76 (serine 376). ZYF0033 inhibits tumor growth in the 4T-1 syngeneic mouse model and leads to increased intratumoral infiltration of DCs, NK cells, and CD107a +CD8 + T cells, but not T cells, PD-1 +CD8 + T cells, TIM-3 +CD8 + Infiltration of T cells and LAG3 +CD8 + T cells was reduced .
NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells .
D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp,Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
4,4'-Methylenebis(2,6-di-tert-butylphenol) (4,4-MBP) is a bisphenol compound. 4,4'-Methylenebis(2,6-di-tert-butylphenol) acts as an inhibitor of sarco/endoplasmic reticulum calcium ATPase (SERCA) with an IC50 value of 17 μM. 4,4'-Methylenebis(2,6-di-tert-butylphenol) can be used in the research of diseases related to calcium homeostasis .
ADI-15878 is a human IgG monoclonal antibody (mAb) targeting Envelope glycoprotein, GP2. ADI-15878 can be used in Ebola virus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .
J5 peptide is an MBP inhibitor that competitively inhibits the binding of MBP85-99 to HLA-DR2. J5 peptide alleviates PLP139-151/MBP85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. J5 peptide can be used in research on inflammatory and immune diseases .
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture .
Amlexanox (Standard) is the analytical standard of Amlexanox. This product is intended for research and analytical applications. Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
MBP (111-129) is a polypeptide that constitutes an immunodominant epitope cluster restricted by HLA-DRB1*0401. MBP (111-129) is an antagonist for the clone HD4-1C2 TCR and an agonist for clone MS2-3C8 TCR. MBP (111-129) can be used for on multiple sclerosis and T cell biology .
MBP Human Pre-designed siRNA Set A contains three designed siRNAs for MBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
3-[(4-Oxo-1,2,3-benzotriazin-3-yl)methylthio]propanoic acid (MBP) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 3-[(4-Oxo-1,2,3-benzotriazin-3-yl)methylthio]propanoic acid can be combined with carrier proteins and used in antigen design .
PRG2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRG2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MBL2 Human Pre-designed siRNA Set A contains three designed siRNAs for MBL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
H3R antagonist 1 is a histamine receptor 3 (H3R) inverse agonist. H3R antagonist 1 increases the expression levels of myelin-associated glycoprotein (MAG) and myeline basic protein (MBP) in differentiating oligodendrocytes. H3R antagonist 1 can be used for the study of multiple sclerosis .
H3R antagonist 1 hydrochloride is a histamine receptor 3 (H3R) inverse agonist. H3R antagonist 1 hydrochloride increases the expression levels of myelin-associated glycoprotein (MAG) and myeline basic protein (MBP) in differentiating oligodendrocytes. H3R antagonist 1 hydrochloride can be used for the study of multiple sclerosis .
D-Glucaric acid tetrahydrate (Standard) (Calcium D-glucarate tetrahydrate (Standard)) is the analytical standard of D-Glucaric acid tetrahydrate (HY-128749A). This product is intended for research and analytical applications. D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp,Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .
Mbp Rat Pre-designed siRNA Set A contains three designed siRNAs for Mbp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mbp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Prg2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prg2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells .
Myelin basic protein, MBP (68-86) is the portion of the 68th to 86th amino acid residues in the MBP protein sequence. Myelin basic protein, MBP (68-86) can act as an autoantigen, triggering the immune system to attack its own myelin. Myelin basic protein, MBP (68-86) is used as one of the immunogens in the experimental autoimmune encephalomyelitis (EAE) animal model to study immune responses associated with multiple sclerosis (MS) .
Myelin Basic Protein (1-11) is an encephalitogenic epitope of myelin basic protein (MBP). Myelin Basic Protein (1-11) can be used for induction of experimental autoimmune encephalomyelitis (EAE) .
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
[pGlu4]-Myelin Basic Protein (4-14) is the phosphorylated 4-14 fragment (EKRPSQRSKYL) of myelin basic protein (MBP) . [pGlu4]-Myelin Basic Protein (4-14) surrounds the serine residue in position 8 of the myelin basic protein .
Tiplimotide (NBI-5788) is an altered peptide ligand (APL) designed from an immunodominant region (83-99) of the neuroantigen myelin basic protein (MBP). Tiplimotide can selectively reduce the production of inflammatory cytokines by pathogenic T-cells. Tiplimotide can be used for the research of multiple sclerosis (MS) .
J5 peptide is an MBP inhibitor that competitively inhibits the binding of MBP85-99 to HLA-DR2. J5 peptide alleviates PLP139-151/MBP85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. J5 peptide can be used in research on inflammatory and immune diseases .
MBP Ac1-9 (4Y) is a synthetic peptide derived from a fragment of myelin basic protein (MBP) that has undergone specific chemical modifications. MBP Ac1-9 (4Y) is able to form a complex with the MHC class II molecule I-Au and activate specific T cell receptor (TCR), thus playing a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). MBP Ac1-9 (4Y) can be used to study autoimmune diseases, especially those involving the central nervous system, such as multiple sclerosis .
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture .
MBP Ac1-9 refers to a peptide fragment of myelin basic protein (MBP). MBP Ac1-9 is an immunodominant epitope in the experimental autoimmune encephalomyelitis (EAE) model, which can induce T cell immune response and lead to pathological changes similar to multiple sclerosis. MBP Ac1-9 can be used to study T cell activation and autoimmune response .
MBP (111-129) is a polypeptide that constitutes an immunodominant epitope cluster restricted by HLA-DRB1*0401. MBP (111-129) is an antagonist for the clone HD4-1C2 TCR and an agonist for clone MS2-3C8 TCR. MBP (111-129) can be used for on multiple sclerosis and T cell biology .
Dirucotide (MBP8298) is a synthetic peptide that consists of 17 amino acids linked in a sequence identical to that of a portion of human myelin basic protein. Dirucotide can be used for the research in autoimmune disorder of the central nervous system, such as Multiple sclerosis (MS) .
MCE MBP Agarose (Dextrin) 6FF is prepared by covalently coupling dextrin to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. It can achieve one-step purification of MBP fusion protein.
Anti-MBP Magnetic Beads are suitable for the detection and purification of MBP-tagged fusion proteins, as well as for immunoprecipitation (IP) and co-immunoprecipitation (Co-IP) applications. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
ADI-15878 is a human IgG monoclonal antibody (mAb) targeting Envelope glycoprotein, GP2. ADI-15878 can be used in Ebola virus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp,Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .
D-Glucaric acid tetrahydrate (Standard) (Calcium D-glucarate tetrahydrate (Standard)) is the analytical standard of D-Glucaric acid tetrahydrate (HY-128749A). This product is intended for research and analytical applications. D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp,Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .
MBP proteins, especially the classical isoforms 4-13, dominate myelin membranes in the central nervous system and are critical for myelination and stability.In contrast, the non-canonical isoform 1-3/Golli-MBP may be involved in early brain development and contribute to transcriptional complexes that influence multiple cellular processes.MBP Protein, Mouse (His) is the recombinant mouse-derived MBP protein, expressed by E.coli , with N-His labeled tag.
MBP proteins, especially the classical isoforms 4-13, dominate myelin membranes in the central nervous system and are critical for myelination and stability. In contrast, the non-canonical isoform 1-3/Golli-MBP may be involved in early brain development and contribute to transcriptional complexes that influence multiple cellular processes. MBP Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived MBP protein, expressed by P. pastoris , with N-6*His labeled tag.
The MBP/MalE protein is an important element in the ABC transporter complex MalEFGK and is dedicated to the active import of maltose and maltodextrin. This multifunctional protein displays binding affinity for maltose and higher maltodextrins such as maltotriose. MBP/MalE Protein, E.coli (Myc, His) is the recombinant E. coli-derived MBP/MalE protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.
Genome polyprotein is a smaller protein chain of covalent linkages that is a key component of virus survival and replication. Zika virus E/Envelope Protein (Domain I, His-MBP) is the recombinant virus-derived Zika virus E/Envelope protein, expressed by E. coli, with a His-MBP, N-His and N-MBP labeled tag.
PLK3 Polo Box Domain Protein, Human (MBP, His) is the recombinant human-derived PLK3 Polo Box Domain, expressed by E. coli , with C-6*His, N-MBP labeled tag. ,
Ebola virus VP40 (matrix VP40 protein) centrally directs virus assembly and budding and has complex interactions with viral ribonucleocapsid and host ESCRT proteins (VPS4, PDCD6IP/ALIX, NEDD4, TGS101). Ebola virus VP40/Matrix VP40 Protein (YP_138522, His-MBP) is the recombinant Virus-derived Ebola virus VP40/Matrix VP40 protein, expressed by E. coli , with N-His, N-MBP labeled tag.
The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PP1ab Protein (His-MBP) is the recombinant Virus-derived SARS-CoV-2 PP1ab protein, expressed by E. coli , with C-6*His labeled tag.
GABARAP Protein is essential for regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) involved in RAC1 activation and downstream signaling. The D6/7 E3 ubiquitin ligase complex, where GABARAP is a key component, contributes to diverse biological processes, including cytoskeletal organization, cell migration, proliferation, and apoptosis. GABARAP Protein, Human (His-MBP) is the recombinant human-derived GABARAP protein, expressed by E. coli , with N-His, N-MBP labeled tag.
SLC12A7/KCC4 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC12A7, expressed by HEK293 , with His, MBP, Flag labeled tag. ,
NLRP7 Protein, Human (sf9, His, Strep, MBP) is the recombinant human-derived NLRP7, expressed by sf9 insect cells , with Strep, His, MBP labeled tag. ,
CDH19 Protein, a calcium-dependent cell adhesion protein, engages in homophilic interactions, primarily connecting cells. This adhesive property suggests a potential role for cadherins, including CDH19, in facilitating the sorting of diverse cell types. CDH19 Protein, Human (Flag-MBP) is the recombinant human-derived CDH19 protein, expressed by E. coli , with N-MBP, N-Flag labeled tag.
The MBL2/COLEC1 protein is a calcium-dependent lectin in innate immune defense that activates the lectin complement pathway by binding to mannose, fucose, and N-acetylglucosamine on microorganisms. MBL2/COLEC1 Protein, Human (HEK293, His) is the recombinant human-derived MBL2/COLEC1 protein, expressed by HEK293 , with C-6*His labeled tag.
MBL1, a calcium-dependent lectin, recognizes microbial moieties, activating the lectin complement pathway.It also binds apoptotic and necrotic cells, aiding uptake by macrophages.As a homotrimer, MBL1 forms higher oligomeric complexes in the endoplasmic reticulum.MBL1's interaction with MASP1 and MASP2 enhances its role in immune response modulation and cellular recognition.MBL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MBL1 protein, expressed by HEK293 , with N-His, N-6*His labeled tag.
MBL1 protein is a calcium-dependent lectin that participates in innate immunity by binding to mannose, fucose and N-acetylglucosamine on microorganisms and activating the lectin complement pathway.MBL1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived MBL1 protein, expressed by HEK293 , with C-hFc labeled tag.
NLRP4 Protein, Human (sf9, His, Strep, MBP) is the recombinant human-derived NLRP4, expressed by sf9 insect cells , with Strep, His, MBP labeled tag. ,
The TARC/CCL17 protein attracts T lymphocytes, particularly Th2 cells, and is involved in inflammation and immunity. It binds to CCR4 on T cells and contributes to GM-CSF/CSF2-induced pain and inflammation. In the brain, it maintains hippocampal microglia morphology and aids in adapting to neuroinflammation. Additionally, it plays a role in wound healing by promoting fibroblast migration. TARC/CCL17 Protein, Dog (Biotinylated, MBP, His-Avi) is the recombinant dog-derived TARC/CCL17 protein, expressed by E. coli , with N-MBP, C-6*His-Avi labeled tag.
The RACK1 protein is a multifunctional scaffold protein that participates in multiple cellular processes by recruiting, assembling, and regulating signaling molecules. As part of the 40S ribosomal subunit, it contributes to translation repression and initiates the ribosome quality control (RQC) pathway by promoting ubiquitination of specific 40S ribosomal subunits. RACK1 Protein, Human (His-MBP) is the recombinant human-derived RACK1 protein, expressed by E. coli , with N-His, N-MBP labeled tag.
Enolase 1 (ENO1) plays a key role in carbohydrate degradation, particularly in the glycolytic pathway, where it catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate.This enzyme activity occurs during the fourth step of glycolysis and marks a critical stage in the conversion of glucose to pyruvate.Enolase 1/ENO1 Protein, Rat (His) is the recombinant rat-derived Enolase 1/ENO1 protein, expressed by E.coli , with N-His labeled tag.
gp36 Protein is a transmembrane protein of HIV-2.gp36 Protein can bind to human T lymphocytes, B lymphocytes and monocytes.gp36 Protein, HIV-2 (His-MBP) is the recombinant Virus-derived gp36 protein, expressed by E.coli , with N-His, N-MBP labeled tag.
SLC25A45 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC25A45 protein, expressed by sf9 insect cells, with N-MBP, C-Flag, N-8*His labeled tag.
SLC22A23 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC22A23 protein, expressed by HEK293, with N-8*His & C-Flag & N-MBP tag.
LOX proteins play a critical role in the post-translational oxidative deamination of peptidyl lysine residues in collagen and elastin precursors, thereby shaping extracellular matrix dynamics. It regulates Ras expression, suggesting potential tumor suppressive effects, affecting cellular homeostasis and cancer-related processes. LOX Protein, Human (sf9, His, MBP) is the recombinant human-derived LOX protein, expressed by Sf9 insect cells, with C-6*His and N-MBP labeled tag.
S100A3 Protein, functioning as a monomer, displays a robust binding affinity for calcium and zinc. It is implicated in calcium-dependent cuticle cell differentiation and contributes to the formation of the hair shaft and hair cuticular barrier. In its citrullinated state, S100A3 can exist as both a homodimer and a homotetramer, indicating potential involvement in various cellular processes associated with these forms. S100A3 Protein, Human (His-MBP) is the recombinant human-derived S100A3 protein, expressed by E. coli , with N-His, N-MBP labeled tag.
The SLC51B protein is an important component of the Ost-α/Ost-β complex, which transports bile acids from enterocytes to portal blood. SLC51B Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC51B protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC30A3 protein is a possible proton-coupled zinc antiporter that mediates cellular zinc homeostasis in the brain. It promotes zinc import into synaptic vesicles and regulates intracellular zinc levels, which are critical for neuronal processes. SLC30A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC30A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC30A2 protein acts as an electrically neutral proton-coupled antiporter, transporting zinc ions into various intracellular organelles. SLC30A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC30A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
SLC35A1 is a key player in intracellular transport, acting as a transporter to transport CMP-sialic acid from the cytoplasm to the Golgi apparatus. As an antiporter, it exchanges CMP-sialic acid for CMP, maintaining cellular homeostasis. SLC35A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
SLC14A1 Protein plays a pivotal role in cellular processes, mediating urea transport across erythrocyte and renal inner medullary collecting duct membranes. It is crucial for the urinary concentrating mechanism and regulates water transport in erythrocytes. With a dual role in urea transport, SLC14A1 maintains cellular osmotic balance and contributes to physiological processes associated with urinary concentration, highlighting its significance. SLC14A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC14A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
SLC35A2 is a key transmembrane protein that acts as an antiporter to transport uridine diphosphate galactose (UDP-galactose) into the Golgi apparatus. The process involves the exchange of UDP-galactose with UMP and exhibits versatility through exchange with AMP and CMP. SLC35A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
SLC52A3 Protein, a vital plasma membrane transporter, facilitates cellular uptake of vitamin B2/riboflavin, crucial for metabolic reactions. Humans rely on external sources for B2, emphasizing SLC52A3's significance. Vitamin B2 transport, underlining its importance in supporting fundamental metabolic pathways for cellular function and human health. SLC52A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC52A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC44A1 protein acts as a choline/H+ and high-affinity ethanolamine/H+ antiporter and is critical for regulating cellular choline and ethanolamine transport. Its dual function actively redistributes intracellular ethanolamine and balances the CDP-Cho and CDP-Etn arms of the Kennedy pathway. SLC44A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC44A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC11A1 protein is a macrophage-specific antiporter that transports metal ions reversibly through proton gradients. It localizes to late endosomal lysosomal membranes and transports divalent cations into acidic compartments, affecting antibacterial activity. SLC11A1 Protein, Human (HEK293, His-MBP, FLAG) is the recombinant human-derived SLC11A1 protein, expressed by sHEK293 , with N-8*His-MBP, C-Flag labeled tag.
TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Wasabi receptor
The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPA1 protein, expressed by HEK293 , with N-10*His, N-MBP, C-Flag labeled tag.
The SLC30A10 protein is a plasma membrane calcium:manganese antiporter that promotes the release of intracellular manganese and the simultaneous import of extracellular calcium. SLC30A10 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC30A10 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC46A1 protein is a proton-coupled folate symporter that utilizes the H(+) gradient in the proximal jejunum to drive folate absorption. It transports folate from the blood to the cerebrospinal fluid and exhibits alternating outward- and inward-open conformational states at acidic pH. SLC46A1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived SLC46A1 protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag.
The ENO1 protein converts 2-phosphoglycerate to phosphoenolpyruvate and is involved in growth control, hypoxia tolerance, and allergic responses. It acts as a receptor and activator of plasminogen, stimulating immunoglobulin production. ENO1 binds to the myc promoter as a transcriptional repressor and may function as a tumor suppressor. Enolase 1/ENO1 Protein, Human (His) is the recombinant human-derived Enolase 1/ENO1 protein, expressed by E. coli , with C-6*His labeled tag.
SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The ENO1 protein converts 2-phosphoglycerate to phosphoenolpyruvate and is involved in growth control, hypoxia tolerance, and allergic responses. It acts as a receptor and activator of plasminogen, stimulating immunoglobulin production. ENO1 binds to the myc promoter as a transcriptional repressor and may function as a tumor suppressor. Enolase 1/ENO1 Protein, Human (His, solution) is the recombinant human-derived ENO1, expressed by E. coli , with C-His labeled tag.
The SLC22A6 protein acts as a Na(+)-independent organic anion (OA)/dicarboxylic acid antiporter and promotes renal elimination by transporting OA from proximal tubule cells into the urine. It transports coenzymes (BH4, BH2, septopterin) and determines blood biopterin levels as well as prostaglandins, cyclic nucleotides, tryptophan metabolites, uremic toxins (e.g. indoxyl sulfate) and xenobiotics (e.g. ochratoxin). SLC22A6 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC22A6 protein, expressed by Sf9 insect cells .
SLC37A4 protein, an endoplasmic reticulum antiporter, transports glucose-6-phosphate into the endoplasmic reticulum lumen while moving inorganic phosphate in the opposite direction. This function is integral to glucose production through glycogenolysis and gluconeogenesis, underscoring SLC37A4's central role in regulating blood glucose levels and maintaining metabolic balance. SLC37A4 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC37A4 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC16A2 protein is a specific thyroid hormone transmembrane transporter that promotes bidirectional movement of thyroid hormone across cell membranes independent of pH or Na(+) gradients. SLC16A2 has a significant preference for substrates such as T3 and T4 and is a key mediator of thyroid hormone transport. SLC16A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC16A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC11A2 protein is a proton-coupled metal ion symporter that selectively transports divalent metal cations, including Cd(2+), Fe(2+), Co(2+), Mn(2+), and less Significant Zn(2+), Ni(2+), VO(2+), the stoichiometric ratio of protons and metal ions is 1:1. It is critical for iron homeostasis, regulating intestinal Fe(2+) absorption, transporting TF-associated endosomal Fe(2+), and promoting Fe(2+) and Mn(2+) entry into mitochondria. SLC11A2 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived SLC11A2 protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag.
SLC21A3 is a Na(+)-independent transporter that greatly facilitates cellular uptake of a variety of organic anions, including bile salts necessary for intestinal absorption. SLC21A3 is responsible for transporting substances such as DHEAS, estrone 3-sulfate, and atROL in human retinal pigment epithelial cells to maintain the integrity of the visual cycle. SLC21A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC21A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC20A2 protein is a sodium-phosphate symporter that transports monovalent phosphate with a stoichiometry of two sodium ions per phosphate ion. Its role in bone mineralization is critical to bone quality and strength. SLC20A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC20A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC52A1 protein acts as a plasma membrane transporter, promoting cellular uptake of vitamin B2/riboflavin that is critical for metabolic responses. Humans rely on external sources to obtain B2, which emphasizes its importance. SLC52A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC52A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC38A1 protein acts as an symporter, facilitating the pH-dependent cotransport of short-chain neutral amino acids and sodium ions across cell membranes. Crucially, it mediates astrocyte-derived glutamine transport to GABAergic interneurons, contributing to de novo GABA synthesis. SLC38A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC38A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
The SLC19A1 protein acts as an antiporter, importing reduced folate and cyclic dinucleotides by exporting organic anions. It acts as a secondary active transporter, exporting intracellular organic anions to facilitate substrate uptake. SLC19A1 Protein, Human (HEK293, His-MBP, Flag) is the recombinant human-derived SLC19A1 protein, expressed by HEK293 , with N-8*His, C-Flag, N-MBP labeled tag.
The SLC29A2 protein is a bidirectional uniporter that maintains cellular nucleoside homeostasis. As a Na(+)-independent transporter, it facilitates the transport of various nucleosides and nucleobases, including inosine, adenosine, uridine, thymidine, cytidine, and guanosine. SLC29A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC29A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
MBP Human Pre-designed siRNA Set A contains three designed siRNAs for MBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
PRG2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRG2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MBL2 Human Pre-designed siRNA Set A contains three designed siRNAs for MBL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mbp Rat Pre-designed siRNA Set A contains three designed siRNAs for Mbp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mbp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Prg2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prg2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
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