2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. NCGC00249987

NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells.

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NCGC00249987 Chemical Structure

NCGC00249987 Chemical Structure

CAS No. : 1384864-80-5

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Based on 1 publication(s) in Google Scholar

NCGC00249987 Related Antibodies

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Description

NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells[1].

IC50 & Target

IC50: 3 μM (Eya2 ED) and 6.9 μM (MBP-Eya2 FL)[1]
In Vitro

NCGC00249987 inhibits Eya2 ED (C-terminal Eya Domain). NCGC00249987 inhibits full length Eya2 including but not other Eya family members[1].
NCGC00249987 binding leads to a conformational change of the active site that is unfavorable for Mg2+ binding, thereby inhibiting Eya2’s Tyr phosphatase activity[1].
NCGC00249987 (5, 10 μM) treatment effectively suppresses migration, invadopodia formation and invasion in Eya2 WT expressing Calu-6 cells, but not in EV Calu-6 cells. NCGC00249987 does not inhibit cell growth or survival[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NCGC00249987 Related Antibodies
Molecular Weight

342.35

Formula

C16H11FN4O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=CC=CC(C(N/N=C/C(O2)=CC=C2SC3=NC=CC=N3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Purity & Documentation
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NCGC00249987 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCGC002499871384864-80-5NCGC 00249987NCGC-00249987PhosphataseTyrphosphataseEya2EDMBP-Eya2FLmigrationinvadopodiaformationinvasionlungcancerC-terminalEyaDomain,Inhibitorinhibitorinhibit

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