1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. NCGC00249987

NCGC00249987 

Cat. No.: HY-133512
Handling Instructions

NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells.

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NCGC00249987 Chemical Structure

NCGC00249987 Chemical Structure

CAS No. : 1384864-80-5

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Description

NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells[1].

IC50 & Target

IC50: 3 μM (Eya2 ED) and 6.9 μM (MBP-Eya2 FL)[1]

In Vitro

NCGC00249987 inhibits Eya2 ED (C-terminal Eya Domain). NCGC00249987 inhibits full length Eya2 including but not other Eya family members[1].
NCGC00249987 binding leads to a conformational change of the active site that is unfavorable for Mg2+ binding, thereby inhibiting Eya2’s Tyr phosphatase activity[1].
NCGC00249987 (5, 10 μM) treatment effectively suppresses migration, invadopodia formation and invasion in Eya2 WT expressing Calu-6 cells, but not in EV Calu-6 cells. NCGC00249987 does not inhibit cell growth or survival[1].

Molecular Weight

342.35

Formula

C₁₆H₁₁FN₄O₂S

CAS No.

1384864-80-5

SMILES

FC1=CC=CC(C(N/N=C/C(O2)=CC=C2SC3=NC=CC=N3)=O)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NCGC00249987NCGC 00249987NCGC-00249987PhosphataseTyrphosphataseEya2EDMBP-Eya2FLmigrationinvadopodiaformationinvasionlungcancerC-terminalEyaDomain,Inhibitorinhibitorinhibit

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NCGC00249987
Cat. No.:
HY-133512
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