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726

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2

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8

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32

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19

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37

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523

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19

Isotope-Labeled Compounds

442

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3

Click Chemistry

325

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-50202
    Etomoxir
    Maximum Cited Publications
    128 Publications Verification

    (R)-(+)-Etomoxir

    		 Carnitine Palmitoyltransferase (CPT) Apoptosis Metabolic Disease Cancer
    Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir
  • HY-50202A
    Etomoxir sodium salt
    Maximum Cited Publications
    128 Publications Verification

    (R)-(+)-Etomoxir sodium salt

    		 Carnitine Palmitoyltransferase (CPT) Apoptosis Metabolic Disease Cancer
    Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig [1].
    Etomoxir sodium salt
  • HY-P990876
    Afimkibart

    PF-06480605; RVT-3101

    		 TNF Receptor NF-κB IFNAR Inflammation/Immunology
    Afimkibart (PF-06480605; RVT-3101) is a fully human monoclonal antibody that selectively inhibits trimeric tumor necrosis factor-like ligand 1A (TL1A). Afimkibart neutralizes active trimeric TL1A, blocks TL1A-induced signaling pathways. Afimkibart inhibits NF-κB activation and IFN-γ production. Afimkibart can be used for the research of inflammatory bowel disease [1].
    Afimkibart
  • HY-112078
    (S,R,S)-AHPC-Me

    VHL ligand 2; E3 ligase Ligand 1a

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein [1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
    (S,R,S)-AHPC-Me
  • HY-12782T
    Iadademstat dihydrochloride
    5+ Cited Publications

    ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride

    		 Histone Demethylase Cancer
    Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.
    Iadademstat dihydrochloride
  • HY-104064
    1A-116
    5+ Cited Publications

    		 Ras Apoptosis Cancer
    1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo [1] .
    1A-116
  • HY-136532
    ZT-1a
    3 Publications Verification

    		 NKCC Neurological Disease
    ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7 μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively [1].
    ZT-1a
  • HY-15522
    WAY-267464
    2 Publications Verification

    		 Oxytocin Receptor Neurological Disease
    WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder [1].
    WAY-267464
  • HY-19612A
    DDP-38003 dihydrochloride
    1 Publications Verification

    		 Histone Demethylase Cancer
    DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM [1].
    DDP-38003 dihydrochloride
  • HY-150074
    STING agonist-18

    		STING ADC Payload Cancer
    STING agonist-18 (compound 1a) is a STING agonist that can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate [1].
    STING agonist-18
  • HY-10242
    Ciluprevir

    BILN 2061; BILN 2061ZW

    		 HCV HCV Protease DNA/RNA Synthesis Infection
    Ciluprevir (BILN 2061; BILN 2061ZW) is an orally active macrocyclic peptide inhibitor of hepatitis C virus (HCV)NS3 protease, with an IC50 of 3 nM. Ciluprevir has Kᵢ values of 0.66 nM and 0.30 nM against genotypes 1b and 1a, respectively. Ciluprevir inhibits HCV RNA replication with an EC50 of 1.2 nM, and its EC50 values against genotypes 1b and 1a are 3 nM and 4 nM, respectively. Ciluprevir shows no significant inhibition against human leukocyte elastase and hepatic cathepsin B. Ciluprevir can be used for genotype 1 HCV infection [1] .
    Ciluprevir
  • HY-U00433
    JMV 2959
    3 Publications Verification

    		 GHSR Neurological Disease Endocrinology
    JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.
    JMV 2959
  • HY-113906A
    (αR,8aS)-GSK1614343

    		GHSR Metabolic Disease
    (αR,8aS)-GSK1614343 is the isomer of GSK1614343 (HY-113906). GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors [1].
    (αR,8aS)-GSK1614343
  • HY-P3915
    Esculentin 1A

    		Bacterial Infection
    Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity [1].
    Esculentin 1A
  • HY-100431A
    IMR-1A
    1 Publications Verification

    		 Notch Drug Metabolite Cancer
    IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A [1].
    IMR-1A
  • HY-176550
    ASIC1a antagonist-1

    		Sodium Channel Neurological Disease
    ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC50 of 27 nM (pH 6.7). ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research [1].
    ASIC1a antagonist-1
  • HY-131994
    STING agonist-16
    1 Publications Verification

    		 STING Infection Cancer
    STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool [1].
    STING agonist-16
  • HY-12294A
    PEAQX tetrasodium hydrate
    5+ Cited Publications

    NVP-AAM077 tetrasodium hydrate

    		 Apoptosis Caspase iGluR Neurological Disease
    PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures [1] .
    PEAQX tetrasodium hydrate
  • HY-13465
    VCH-916
    1 Publications Verification

    		 HCV Infection
    VCH-916 is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase with sub-micromolar IC50 values versus genotype 1a and 1b replicons. VCH-916 binds to Thumb Site II. VCH-916 can be used for the research of hepatitis c virus (hcv) infection [1].
    VCH-916
  • HY-164220
    PPM1A-IN-1

    		Phosphatase Bacterial Infection
    PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis [1].
    PPM1A-IN-1
  • HY-12294
    PEAQX

    NVP-AAM077

    		 Caspase Apoptosis iGluR Neurological Disease
    PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures [1] .
    PEAQX
  • HY-147060
    Dyrk1A-IN-3

    		DYRK Neurological Disease
    Dyrk1A-IN-3 (Compound 8b), a highly selective dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC50=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease [1].
    Dyrk1A-IN-3
  • HY-115938
    BEC2

    		Carnitine Palmitoyltransferase (CPT) Others Metabolic Disease Cancer
    BEC2 is an ester derivative of Baicalin, with good lipid-lowering activity. BEC2 can direct activate the carnitine palmitoyltransferase 1A (CPT1A) [1].
    BEC2
  • HY-U00433A
    JMV 2959 hydrochloride
    3 Publications Verification

    		 GHSR Neurological Disease Endocrinology
    JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
    JMV 2959 hydrochloride
  • HY-12981
    RG7713
    2 Publications Verification

    RO5028442

    		 Vasopressin Receptor Cardiovascular Disease Neurological Disease Metabolic Disease
    RG7713 (RO5028442) is a highly potent, selective and brain-penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
    RG7713
  • HY-168735
    SLC26A4-IN-1

    		Chloride Channel Others
    SLC26A4-IN-1 (compound 1a) is a pendrin/SLC26A4 inhibitor. pendrin is a Cl -/HCO3 - exchanger [1].
    SLC26A4-IN-1
  • HY-159114
    Whole Glucan Particles

    		Biochemical Assay Reagents Inflammation/Immunology
    Whole Glucan Particles is a Dectin-1a agonist. Whole Glucan Particles activates the innate immune system to improve the function of macrophages, monocytes and other immune cells [1].
    Whole Glucan Particles
  • HY-106954
    Upidosin

    Rec 15/2739; Recordati 15/2739; SB 216469

    		 Adrenergic Receptor Inflammation/Immunology
    Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction [1].
    Upidosin
  • HY-P99138
    Anti-Mouse IL-1a Antibody (ALF-161)

    		Interleukin Related Inflammation/Immunology Cancer
    Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8 + T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for researches on immune response and cancer such as breast cancer [1] .
    Anti-Mouse IL-1a Antibody (ALF-161)
  • HY-W420033
    (S)-(+)-Etomoxir

    		Acyltransferase Carnitine Palmitoyltransferase (CPT) Others
    (S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig [1].
    (S)-(+)-Etomoxir
  • HY-150074A
    STING agonist-18 diTFA

    		STING ADC Payload Cancer
    STING agonist-18 (compound 1a) diTFA is a STING agonist that can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate [1].
    STING agonist-18 diTFA
  • HY-108790
    Peginterferon beta-1a

    Peginterferon β-1a

    		 Apoptosis Neurological Disease Cancer
    Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS) [1].
    Peginterferon beta-1a
  • HY-137584
    1a,1b-Dihomo prostaglandin E1

    1a,1b-Dihomo PGE1

    		 Prostaglandin Receptor Cardiovascular Disease
    1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is an E1-type prostaglandin. 1a,1b-Dihomo prostaglandin E1 can be used for research on platelet aggregation [1].
    1a,1b-Dihomo prostaglandin E1
  • HY-W128112
    1-(a-D-ribofuranosyl)uracil

    alpha-D-Ribofuranoside,2,4(1H,3H)-pyrimidinedione-1

    		 Nucleoside Antimetabolite/Analog Cancer
    1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
    1-(a-D-ribofuranosyl)uracil
  • HY-19612B
    DDP-38003 trihydrochloride

    		Histone Demethylase Cancer
    DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
    DDP-38003 trihydrochloride
  • HY-110001
    (S)-WAY 100135 dihydrochloride

    		5-HT Receptor Neurological Disease
    (S)-WAY 100135 dihydrochloride is a highly selective and potent antagonist of 5-HT 1A (IC50=33.9 nM). (S)-WAY 100135 dihydrochloride has anxiolytic activity in animal models [1].
    (S)-WAY 100135 dihydrochloride
  • HY-N13946
    Pyralomicin 1a

    		Antibiotic Bacterial Infection
    Pyralomicin 1a is an antibiotic with antibacterial activity [1].
    Pyralomicin 1a
  • HY-N14581
    Roselipin 1A

    		Acyltransferase Infection
    Roselipin 1A inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm [1].
    Roselipin 1A
  • HY-146483
    Anti-Aβ agent 1A

    		Amyloid-β Neurological Disease Inflammation/Immunology
    Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H2O2 through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD) [1].
    Anti-Aβ agent 1A
  • HY-134913
    Rhodblock 1a

    		ROCK Cardiovascular Disease Cancer
    Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway. It inhibits the normal formation of the cleavage furrow during cell division by interfering with the localization and function of Rho pathway proteins, causing some cells to fail to form a cleavage furrow or the formed cleavage furrow to break, resulting in binucleated cells. Rhodblock 1a can be used to study the mechanism of cell division and is expected to be used in the research of diseases such as cardiovascular diseases and cancer [1].
    Rhodblock 1a
  • HY-N14785
    Deflectin 1a

    		Antibiotic Bacterial Infection Cancer
    Deflectin 1a is an antibiotic with the activity of lysing bacteria, lysing red blood cells and inhibiting Ehrlich ascites cancer cells, and its activity can be offset by adding serum or serum albumin [1].
    Deflectin 1a
  • HY-163121
    PST3.1a

    		Glycosyltransferase TGF-β Receptor FAK Galectin Collagen Endocrinology Cancer
    PST3.1a is an orally active and brain-penetrant N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with a human IC50 of 2 µM. PST3.1a inhibits TGFβR and FAK signaling pathway activity. PST3.1a alters β1,6-GlcNAc N-glycans and microtubule/microfilament integrity, increases OLIG2 expression, and inhibits proliferation, migration, invasiveness, and clonogenic capacities of glioblastoma initiating cells. PST3.1a reduces invasive and proliferative capacity of glioblastoma initiating cells in orthotopic graft models, increases overall survival of orthotopic graft model mice. PST3.1a blunts MGAT5 overexpression, decreases renal fibrosis via collagen 1, collagen 4, and galectin 3 downregulation in a rat chronic kidney disease model. PST3.1a can be used for the research of glioblastoma multiforme and chronic kidney disease [1] .
    PST3.1a
  • HY-50202R
    Etomoxir (Standard)

    (R)-(+)-Etomoxir (Standard)

    		 Carnitine Palmitoyltransferase (CPT) Apoptosis Reference Standards Metabolic Disease Cancer
    Etomoxir (Standard) is the analytical standard of Etomoxir. This product is intended for research and analytical applications. Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir (Standard)
  • HY-168265
    Dyrk1A-IN-11

    		DYRK Neurological Disease Cancer
    Dyrk1A-IN-11 (compound 166) is a potent dual-specificity tyrosine phosphorylation- regulated 1A (DYRK1A) inhibitor with an EC50 value of 0.0021 µM. Dyrk1A-IN-11 inhibits the Phospho-Tau (Thr212) with an EC50 value of 0.0361 µM [1].
    Dyrk1A-IN-11
  • HY-W006672
    Dibenzo[b,e]oxepin-11(6H)-one

    		Parasite Infection
    Dibenzo[b,e]oxepin-11(6H)-one (Compound 1a) is a dibenzoxepinone derivative that exhibits significant antiparasitic activity [1].
    Dibenzo[b,e]oxepin-11(6H)-one
  • HY-D1453
    Immune initiator-1

    		Biochemical Assay Reagents Cancer
    Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma [1].
    Immune initiator-1
  • HY-100431AR
    IMR-1A (Standard)

    		Reference Standards Notch Drug Metabolite Cancer
    IMR-1A (Standard) is the analytical standard of IMR-1A. This product is intended for research and analytical applications. IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].
    IMR-1A (Standard)
  • HY-173271
    GHSR-1a agonist-1

    		GHSR Endocrinology
    GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a), with an EC50 of 0.49 nM. GHSR-1a agonist-1 can effectively stimulate the release of endogenous growth hormone by activating GHSR-1a. GHSR-1a agonist-1 administered orally at a dose as low as 0.1 mg/kg can increase the body weight and body length of 4-week-old rats. GHSR-1a agonist-1 can be used in the research field of growth and development retardation in children [1].
    GHSR-1a agonist-1
  • HY-100840
    (S)-4C3HPG

    (S)-4-Carboxy-3-hydroxyphenylglycine

    		 mGluR Neurological Disease
    (S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice [1].
    (S)-4C3HPG
  • HY-136267
    HCV-IN-30

    		HCV Infection
    HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively [1].
    HCV-IN-30

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