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464-71-1

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Clerodin
Clerodin
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Cat. No.: HY-N20639
CAS No.: 464-71-1
Synonyms: 3-Deoxycaryoptinol
Category:  

Labiatae Terpenoids Diterpenoids Plants Clerodendrum infortunatum Dennst.

Target:  

Caspase Apoptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase

Clerodin (3-Deoxycaryoptinol) is a natural diterpenoid compound that can be isolated from traditional Chinese medicinal plants such as Clerodendrum infortunatum. Clerodin exhibits caspase-3 regulation, apoptosis induction, cell cycle arrest, ROS induction and glutathione depletion effects, along with anti-cancer and antifeedant activities. It shows selective cytotoxicity against leukemia cells and breast cancer cells, but has no obvious toxicity to normal human blood cells and lymphocytes. Clerodin also reduces the feeding behavior of Helicoverpa armigera larvae on cabbage leaf discs, but has no significant contact toxicity to these larvae. Clerodin can be used in research related to acute monocytic leukemia and human breast cancer .
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