Search Result

Results for "

4a

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nuclear Hormone Receptor 4A/NR4A (5) 5-HT Receptor (3) Acyltransferase (2) ADC Antibody (1) ADC Payload (2) Adenosine Receptor (1) Akt (2) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) Angiotensin Receptor (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (13) Autophagy (3) Bacterial (5) Bcl-2 Family (1) BCRP (1) Biochemical Assay Reagents (4) Btk (1) c-Fms (2) c-Myc (1) Cannabinoid Receptor (3) Caspase (3) CD20 (1) Cdc42-binding kinase (1) CDK (5) CFTR (1) Cholinesterase (ChE) (6) COX (2) Cyclophilin (1) Cytochrome P450 (3) Dengue Virus (1) DNA/RNA Synthesis (6) Dopamine Receptor (1) Drug Derivative (5) Drug Intermediate (4) Drug Isomer (1) Drug-Linker Conjugates for ADC (1) Dynamin (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (1) EGFR (3) Endogenous Metabolite (4) Environmental Pollutants (1) Epigenetic Reader Domain (1) ERK (3) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (28) FAP (1) Farnesyl Transferase (1) Ferroptosis (1) Flavivirus (1) Folate Receptor (FR) (1) Fungal (1) G Protein-coupled Receptor Kinase (GRK) (1) Galectin (1) GCGR (1) Glycosidase (2) HBV (3) HCV (31) HCV Protease (33) HDAC (1) Hedgehog (1) Histone Acetyltransferase (1) Histone Methyltransferase (1) HIV (2) HMG-CoA Reductase (HMGCR) (1) HSP (1) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Insecticide (1) Interleukin Related (1) Isotope-Labeled Compounds (5) JNK (1) Keap1-Nrf2 (1) Liposome (5) mAChR (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (1) mGluR (2) MHC (1) Microtubule/Tubulin (2) MMP (1) MOFs (2) Molecular Glues (1) Monoamine Oxidase (1) MyD88 (1) Necroptosis (1) Neurokinin Receptor (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) OGT (1) P-glycoprotein (2) P2X Receptor (1) p38 MAPK (1) PARP (2) PD-1/PD-L1 (1) PDGFR (1) PGE synthase (1) Phosphatase (1) PI3K (1) Pim (1) Potassium Channel (1) PROTACs (4) Raf (1) Ras (1) Reactive Oxygen Species (ROS) (3) Reference Standards (12) SARS-CoV (20) Small Interfering RNA (siRNA) (146) Sodium Channel (1) Src (1) STAT (1) STING (1) TNF Receptor (1) Toll-like Receptor (TLR) (3) Transmembrane Glycoprotein (1) TREM receptor (1) VEGFR (2) Virus Protease (1)
By Research Areas:	Cancer (92) Cardiovascular Disease (4) Endocrinology (1) Infection (56) Inflammation/Immunology (15) Metabolic Disease (13) Neurological Disease (25)
Click Chemistry:	PROTAC Synthesis (1) Azide (2)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (39) Mouse Pre-designed siRNA Sets (36) Cationic Lipids (2) Human Pre-designed siRNA Sets (71) siRNAs (146)

356

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

131

Recombinant Proteins

Isotope-Labeled Compounds

107

Antibodies

Click Chemistry

149

Oligonucleotides

Targets Recommended: Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10038

A 922500 25+ Cited Publications DGAT-1 Inhibitor 4a	Acyltransferase	Metabolic Disease
A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of 9 and 22 nM against human and mouse DGAT-1, respectively.

HY-108473

CU-CPT 4a 10+ Cited Publications TLR3-IN-1	Toll-like Receptor (TLR)	Cancer
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .

HY-17634

Glecaprevir 5+ Cited Publications ABT-493	HCV HCV Protease SARS-CoV	Infection
Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC₅₀ values ranging from 3.5 to 11.3 nM. Glecaprevir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 4.09 μM .

HY-13863

Hydroxy-Dynasore 15+ Cited Publications Dyngo-4a	Dynamin	Neurological Disease
Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC₅₀ values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC₅₀ of 5.7 μM.

HY-13251

Silvestrol 50+ Cited Publications (-)-Silvestrol	Eukaryotic Initiation Factor (eIF) Apoptosis Autophagy	Cancer
Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn.. Silvestrol induces autophagy and caspase-mediated apoptosis .

HY-12594

Paritaprevir 10+ Cited Publications ABT-450; Veruprevir	HCV Protease HCV SARS-CoV	Infection
Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC₅₀s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) ^[4].

HY-148559

4A3-SC8	Liposome	Cancer
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model .

HY-10238

Danoprevir 15+ Cited Publications ITMN-191; R7227; RO5190591; RG7227	HCV Protease HCV SARS-CoV	Infection
Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC₅₀ of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC₅₀ higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s=0.2-0.4 nM) as well as 2b and 3a (IC₅₀s=1.6, 3.5 nM) . Danoprevir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 0.05 μM .

HY-16576A

SMI-4a 1 Publications Verification TCS-PIM-1-4a	Pim	Cancer
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC₅₀ of 24 μM and a K_i of 0.6 μM. SMI-4a also inhibits Pim-2 (IC₅₀ of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity .

HY-143320

STING agonist-17	STING	Cancer
STING agonist-17 (compound 4a) is a potent STING agonist with an IC₅₀ value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization .

HY-19356A

Didesmethylrocaglamide	Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC₅₀ of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity .

HY-153373

4A3-Cit 1 Publications Verification	Liposome	Others
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

HY-101785

eIF4A3-IN-2 1 Publications Verification	Eukaryotic Initiation Factor (eIF) Autophagy	Cancer
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC₅₀ of 110 nM .

HY-129434A

4aα,7α,7aα-Nepetalactone 1 Publications Verification	Bacterial	Infection
4aα,7α,7aα-Nepetalactone exhibits antibacterial activity, and inhibits Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Enterococcus faecalis.

HY-120669

PF-06761281 1 Publications Verification	Sodium Channel	Metabolic Disease
PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC₅₀ values of 0.51, 13.2 and 14.1 µM against HEK_NaCT, HEK_NaDC1 and HEK_NaDC3, respectively .

HY-176844

eIF4A-IN-1 intermediate	ADC Payload Drug Intermediate	Cancer
eIF4A-IN-1 intermediate (Compound 71E) is an intermediate of Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-1 intermediate can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-155659

4A7C-301 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease
4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease .

HY-177069

4A3-SC7	Liposome	Others
4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform .

HY-18563

4-Phenoxybenzylamine	HCV	Infection
4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC₅₀ of about 500 μM against FL NS3/4a.

HY-P99718

Lupartumab BAY 1112623	ADC Antibody	Cancer
Lupartumab (BAY 1112623) is an anti-LYPD3 (C4.4A) monoclonal antibody that can be used for the synthesis of antibody-drug conjugate BAY 1129980 .

HY-135108

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

HY-W011400

TLR1 3 Publications Verification	MyD88	Inflammation/Immunology
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses .

HY-N16021

4A-MPLA ammonium	Toll-like Receptor (TLR) Cdc42-binding kinase Galectin	Inflammation/Immunology
4A-MPLA ammonium is an orally active *TLR4* agonist. 4A-MPLA ammonium induces TLR4 endocytosis dependent on Cdc42 and galectin-3, triggering TRIF-mediated signaling and sustained IFN-β production. 4A-MPLA ammonium promotes lipid droplet formation, upregulates interferon-stimulated genes and type I IFN signaling genes, downregulates lysosome/phagosome function genes, and modulates tolerogenic dendritic cell function. 4A-MPLA ammonium can be used for the research of colitis .

HY-10243

Vaniprevir MK-7009	HCV HCV Protease	Infection
Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.

HY-P99719

Lupartumab Amadotin BAY 1129980; Anti-C4.4a antibody-drug conjugates	Antibody-Drug Conjugates (ADCs)	Cancer
Lupartumab Amadotin (BAY 1129980) is an antibody–drug conjugate (ADC) consisting of a fully human *C4.4A* (LYPD3)-targeting mAb (BAY 1135626) (HY-147281) conjugated to a novel, highly potent derivative of the microtubule-disrupting cytotoxic drug auristatin via a noncleavable alkyl hydrazide linker. Lupartumab Amadotin can be used for the research of non-small cell lung cancer .

HY-119942

c-Fms-IN-8	c-Fms	Cancer
c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC₅₀ of 9.1 nM .

HY-172526

4A3-SCC-10	Liposome	Cancer
4A3-SCC-10 is a biodegradable ionizable lipid containing disulfide bonds. 4A3-SCC-10 can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. 4A3-SCC-10 can be used for broad applications such as gene editing, vaccine, and cancer detection .

HY-138815

(S)-N-(1H-Indole-3-acetyl)tryptophan	Glycosidase	Metabolic Disease
(S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .

HY-147281

BAY 1135626	Drug-Linker Conjugates for ADC	Cancer
BAY 1135626 is used to synthesize BAY 1129980, and use to anti-tumor research. BAY 1129980 is a Auristatin-based anti-C4.4A (LYPD3) antibody–agent conjugate (ADC), is used to non–small cell lung cancer (NSCLC) research .

HY-176843

eIF4A-IN-2	Eukaryotic Initiation Factor (eIF) ADC Payload	Cancer
eIF4A-IN-2 (Compound 93) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-145360

eIF4A3-IN-6	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-6 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), such as *eIF4AI* and *eIF4AII. eIF4A3-IN-6* has the potential for the research of *eIF4A* dependent diseases, including the research of cancer (extracted from patent US20170145026A1) .

HY-149631

HFY-4A	HDAC	Cancer
HFY-4A is a HDAC inhibitor. HFY-4A inhibits breast cancer cell proliferation, migration, and invasion, and induces cell apoptosis. HFY-4A induces immunogenic cell death (ICD). HFY-4A inhibits tumor growth in breast cancer xenograft mouse models .

HY-109571

HZ-1157	Flavivirus Dengue Virus HCV Protease	Infection Inflammation/Immunology
HZ-1157 inhibits HCV NS3/4A protease with an IC₅₀ of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC₅₀ = 0.15 μM) and is a relatively nontoxic (CC₅₀ > 10 μM) dengue antiviral agent .

HY-125278

OGT-IN-4	OGT	Others
OGT-IN-4 (compound 4a) is an O-GlcNAc transferase (OGT) inhibitor with a K_d of 8 nM. OGT-IN-4 can be utilized in OGT related research .

HY-156450

ERK5-IN-5	ERK	Cancer
ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-5 exhibits good anti-proliferative activity with the IC₅₀ value of 6.23 µg/mL for A549 cells .

HY-103090

NPS ALX Compound 4a	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-103090A

NPS ALX Compound 4a dihydrochloride	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-19557

IDX-320	Drug Derivative HCV Protease	Infection
IDX-320 is a Pipecolic acid (HY-Y0669) derivative. IDX-320 inhibits NS3/4a proteases across genotypes 1a, 1b, 2a, and 4a with an IC₅₀ 0.8-1.9 nM. IDX-320 can be used in the research of HCV infection .

HY-135324

4,4'-Iminodiphenol	Estrogen Receptor/ERR	Endocrinology
4-Propionamidophenol (compound 4a) is an inactive estrogen receptor ligand based on the diphenylamine skeleton .

HY-14404

MK-1220	HBV HCV Protease	Infection
MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a K_i of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC₅₀s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection .

HY-162274

Oxazepine	Hedgehog Antibiotic	Infection Cancer
Oxazepine (compound 4a) has antimicrobial viability via binding OMPA/ exo-1,3-beta-glucanase proteins. Oxazepine is a hedgehog signaling inhibitor with antitumor viability .

HY-180121

tBu-MTX-CO-NH-C2-O-C2-N3	Drug Intermediate	Others
tBu-MTX-CO-NH-C2-O-C2-N3 (Compound 4a) is an azide compound, which can be used as a drug intermediate for the construction of chemical inducers of dimerisation.

HY-129768

CMLD012072	Eukaryotic Initiation Factor (eIF)	Cancer
CMLD012072 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012072 can induce RNA clamping of *eIF4A1* and *eIF4A2* and possess potent anti-neoplastic activity .

HY-108473R

CU-CPT 4a (Standard) TLR3-IN-1 (Standard)	Reference Standards Toll-like Receptor (TLR)	Cancer
CU-CPT 4a (Standard) is the analytical standard of CU-CPT 4a (HY-108473). This product is intended for research and analytical applications. CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .

HY-145359

eIF4A3-IN-5	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-5 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), such as *eIF4AI* and *eIF4AII. eIF4A3-IN-5* has the potential for the research of *eIF4A* dependent diseases, including the research of cancer (extracted from patent US20170145026A1) .

HY-10038R

A 922500 (Standard) DGAT-1 Inhibitor 4a (Standard)	Acyltransferase Reference Standards	Metabolic Disease
A 922500 (Standard) is the analytical standard of A 922500 (HY-10038). This product is intended for research and analytical applications. A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of 9 and 22 nM against human and mouse DGAT-1, respectively.

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .

HY-E71239A

α-Glucuronidase 4A, Thermotoga maritima	Biochemical Assay Reagents	Others
α-Glucuronidase 4A, Thermotoga maritima (EC 3.2.1.139) is an enzyme that catalyzes the chemical reaction: an alpha-D-glucuronoside + H2O ? an alcohol + D-glucuronate. Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H2O, whereas its two products are alcohol and D-glucuronate. α-Glucuronidase 4A, Thermotoga maritima (EC 3.2.1.139) belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O-and S-glycosyl compounds.

HY-N10922

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone	Others	Cancer
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

HY-Z8472

Dihydromevinolin Lovastatin EP impurity E; 4a,5-Dihydromevinolin	Endogenous Metabolite HMG-CoA Reductase (HMGCR)	Metabolic Disease
Dihydromevinolin is a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Dihydromevinolin is a HMG-CoA reductase inhibitor .

Cat. No.	Product Name	Type

HY-153373

4A3-Cit 1 Publications Verification	Biochemical Assay Reagents
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

Cat. No.	Product Name	Target	Research Area

HY-135108

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

HY-138815

(S)-N-(1H-Indole-3-acetyl)tryptophan	Glycosidase	Metabolic Disease
(S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .

HY-P4035

HCV NS4A Protein (18-40) (JT strain)	HCV	Infection
HCV NS4A Protein (18-40) (JT strain) is an HCV NS4A peptide, which comprised residues 18 to 40 of the NS4A protein and is known to increase the catalytic efficiency of NS3 protease .

HY-P5916

VSTx-3 κ-Theraphotoxin-Gr4a; Kappa-TRTX-Gr4a; Voltage sensor toxin 3; Peptide F	Peptides Potassium Channel	Neurological Disease
VSTx-3 is a K_V channel blocker. VSTx-3 is demonstrated to be a potent, TTX-sensitive sodium channel blocker and especially, a potent blocker of NaV1.8 channels (IC₅₀ 0.19 μM for hNaV1.3, 0.43 μM for hNaV1.7 and 0.77 μM for hNaV1.8 channels).

HY-P10608

KK4A peptide	HCV	Infection
KK4A peptide is a small peptide derived from nonstructural protein 4A (NS4A) of hepatitis C virus (HCV) that significantly increases the catalytic efficiency of NS3 protease. The KK4A peptide may be used to gain insights into the function and mechanism of the HCV NS3 protease, thereby advancing research into HCV infection .

HY-P10324

TAT-p16 p16^INK4a peptide	Peptides	Cancer
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99718

Lupartumab BAY 1112623	ADC Antibody	Cancer
Lupartumab (BAY 1112623) is an anti-LYPD3 (C4.4A) monoclonal antibody that can be used for the synthesis of antibody-drug conjugate BAY 1129980 .

HY-P99308

Ocaratuzumab AME 133v; LY 2469298; Humanized Anti-MS4a1 Recombinant Antibody	CD20	Cancer
Ocaratuzumab (AME 133v) is an Fc-engineered humanized IgG1 anti-CD20 monoclonal antibody, with a K_d of ~100 pM. Ocaratuzumab exhibits more effective antibody-dependent cell-mediated cytotoxicity (ADCC) .

HY-P990218

Anti-Mouse IL-21R Antibody (4A9)	Interleukin Related	Infection Inflammation/Immunology Cancer
Anti-Mouse IL-21R Antibody (4A9) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-21R. Anti-Mouse IL-21R Antibody (4A9) blocks IL-21 signaling. Anti-Mouse IL-21R Antibody (4A9) can be used for the researches of cancer, infection immunology and inflammation, such as psoriasis, hepatocellular carcinoma and C. rodentium infection .

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .

HY-P990849

Anti-CSF1R/CD115 Antibody (2-4A5-4)	c-Fms	Others
Anti-CSF1R/CD115 Antibody (2-4A5-4) is a kind of rat IgG1 κ chimeric antibody inhibitor, targeting to human CSF1R/CD115. Anti-CSF1R/CD115 Antibody (2-4A5-4) can neutralize colony stimulating factor 1 receptor (CSF1R), also known as CD115. Anti-CSF1R/CD115 Antibody (2-4A5-4) can be used for the detections of immunohistochemistry, functional assays and flow cytometry .

HY-P990813

Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11)	MHC	Cancer
Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) is a mouse-derived IgG1 antibody inhibito, targeting to mouse Nonclassical MHC Class I molecule Qa-1b. Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) reacts with the mouse non-classical MHC class I molecule Qa-1b. Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) can be used for the research of cancer, such as B16F10 tumor .

HY-P992381

IBI352g4a	Drug Derivative	Cancer
IBI352g4a is a humanized IgG1 monoclonal antibody targeting PVRIG (K_d = 0.53 nM) and acts as a PVRIG/PVRL2 inhibitor. The anti-tumor effect of IBI352g4a depends on the binding of its Fc region to FcγR. IBI352g4a binds to the extracellular domains of human and cynomolgus monkey PVRIG, and blocks the PVRIG-PVRL2 interaction. IBI352g4a induces NK cell activation, promotes their degranulation and tumor killing. IBI352g4a can be used in the research of gastric cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13251

Silvestrol 50+ Cited Publications (-)-Silvestrol	Natural Products Agave americana Linn. Classification of Application Fields Agavaceae Plants Disease Research Fields Source Classification Cancer	Eukaryotic Initiation Factor (eIF) Apoptosis Autophagy
Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn.. Silvestrol induces autophagy and caspase-mediated apoptosis .

HY-N12586

Pheophytin a	Suaeda vermiculata Forssk. ex J.F.Gmel. Structural Classification Alkaloids Other Alkaloids Amaranthaceae Plants Source Classification	ERK Reactive Oxygen Species (ROS) COX PGE synthase STAT HCV HCV Protease
Pheophytin a is a multi-target inhibitor, anticancer agent, antioxidant and antiviral agent. Pheophytin a directly binds to and inhibits *HCV-NS3/4A* protease (IC₅₀=0.89 μM) to block viral replication. Pheophytin a also scavenges free radicals, reduces ferric ions, and exhibits cytotoxic activity against breast cancer cells. Pheophytin a effectively inhibits LPS-induced production of nitric oxide, prostaglandin E2, NOS2 and COX-2, as well as various pro-inflammatory cytokines, by downregulating the transcription levels of inflammatory mediators and blocking the ERK1/2 and STAT-1 pathways. In a low nerve growth factor environment, Pheophytin a also enhances ERK1/2 phosphorylation and synergistically promotes neurite outgrowth through MAPK pathway. Pheophytin a can be used to investigate the pathogenic mechanisms of diseases including chronic hepatitis C, sepsis, breast cancer and Alzheimer's disease ^[4] .

HY-129434A

4aα,7α,7aα-Nepetalactone 1 Publications Verification	Infection other families Iridoids Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification	Bacterial
4aα,7α,7aα-Nepetalactone exhibits antibacterial activity, and inhibits Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Enterococcus faecalis.

HY-N16021

4A-MPLA ammonium	Structural Classification Lipid	Toll-like Receptor (TLR) Cdc42-binding kinase Galectin
4A-MPLA ammonium is an orally active *TLR4* agonist. 4A-MPLA ammonium induces TLR4 endocytosis dependent on Cdc42 and galectin-3, triggering TRIF-mediated signaling and sustained IFN-β production. 4A-MPLA ammonium promotes lipid droplet formation, upregulates interferon-stimulated genes and type I IFN signaling genes, downregulates lysosome/phagosome function genes, and modulates tolerogenic dendritic cell function. 4A-MPLA ammonium can be used for the research of colitis .

HY-113337

Ap4A P1,P4-Di-(adenosine-5')-tetraphosphate	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Apoptosis
Ap4A (P1,P4-Di-(adenosine-5')-tetraphosphate) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A induces apoptosis .

HY-N10922

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone	Terpenoids Celastraceae Diterpenoids Celastrus Plants Source Classification	Others
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

HY-Z8472

Dihydromevinolin Lovastatin EP impurity E; 4a,5-Dihydromevinolin	Microorganisms Terpenoids Diterpenoids Source Classification	Endogenous Metabolite HMG-CoA Reductase (HMGCR)
Dihydromevinolin is a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Dihydromevinolin is a HMG-CoA reductase inhibitor .

HY-N10683

1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran	Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f. Source Classification	Others
1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran is a sesquiterpenoid isolated from the root bark of Tripterygium hypoglaucum containing a benzoyl and a cinnamoyl group .

HY-N8192

5-Hydroxy-3-(4-hydroxybenzyl)-7-methoxychroman-4-one	other families Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
5-Hydroxy-3-(4-hydroxybenzyl)-7-methoxychroman-4-one (4a) is a natural compound .

HY-N8520

Variculanol	Microorganisms Terpenoids Sesquiterpenes Source Classification	Bacterial
Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor .

HY-N10906

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one	Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Source Classification	Others
(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone .

HY-N13786

4a-Demethoxysampsone B	Structural Classification Hypericum reptans Hook. f. & Thomson ex Dyer Monophenols Phenols Hypericaceae Plants Source Classification	Drug Derivative
4a-Demethoxysampsone B is a natural phenolic compound.

HY-N12021

7(8)-Dehydroschisandrol A	Schisandra sphenanthera Rehd. et Wils Lignans Phenylpropanoids Plants Schisandraceae Source Classification	Others
7(8)-Dehydroschisandrol A (Compound 4a) is a lignan can be isolated from Schizandra chinensis Baill. 7(8)-Dehydroschisandrol A has a weak inhibitory effect on stress-induced gastric ulcer .

HY-N18257

(4E,6E,12E)-4,6,12-Tetradecatriene-8,10-diyn-1-ol	Structural Classification Natural Products Atractylodes koreana (Nakai) Kitam. Asteraceae Plants Source Classification	Others
(4E,6E,12E)-4,6,12-Tetradecatriene-8,10-diyn-1-ol (Compound 4a) is a natural product that can be isolated from the rhizomes of Atractylis koreana .

HY-N19689

*4''-Acetyl-4-(a-L-Rhamnopyranosyloxy)-benzylglucosinolate*	Structural Classification Moringa oleifera Lam. Moringaceae Plants Saccharides Monosaccharides Source Classification	Drug Derivative
4''-Acetyl-4-(a-L-Rhamnopyranosyloxy)-benzylglucosinolate is a plant secondary metabolite that can be found in the leaves of Moringa oleifera and Moringa stenopetala. 4''-Acetyl-4-(a-L-Rhamnopyranosyloxy)-benzylglucosinolate can be used for research on cancer and inflammatory diseases .

Cat. No.	Product Name	Chemical Structure

HY-10235S

Telaprevir-d4
Telaprevir-d₄ is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide . Telaprevir inhibits SARS-CoV-2 3CLpro activity ^[4].

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

HY-131905S

BMS-986144
BMS-986144 is a third-generation, pan-genotype (GT) NS3/4A protease inhibitor. BMS-986144 inhibits HCV replicon with EC₅₀s of 2.3, 0.7, 1.0, 12, 8.0, and 5.8 nM for GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, and 1b D168V, respectively. BMS-986144 has the potential for the research of HCV infection .

HY-W741425

21-O-Acetyl dexamethasone 9,11-epoxide-d5
21-O-Acetyl dexamethasone 9,11-epoxide-d₅ is the deuterium labeled 2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-Hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate (Dexamethasone Acetate Impurity) (HY-Z8003).

HY-138815S

(S)-N-(1H-Indole-3-acetyl)tryptophan-d4
(S)-N-(1H-Indole-3-acetyl)tryptophan-d₄ is deuterium labeled (S)-N-(1H-Indole-3-acetyl)tryptophan. (S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .