1 Result for "

53729-52-5

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "53729-52-5" in MCE Product Catalog:

Bruceantinol
Bruceantinol
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Cat. No.: HY-N8146
CAS No.: 53729-52-5
Category:  

Infection Triterpenes Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.

Target:  

STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK

Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50 = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .
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