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60941-76-6

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1 Results for "60941-76-6" in MCE Product Catalog:

1-Benzyl-I3C
1-Benzyl-I3C
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Cat. No.: HY-N10159
CAS No.: 60941-76-6
Category:  

Natural Products Brassica oleracea L. Plants Brassicaceae

Target:  

E1/E2/E3 Enzyme

1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .
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