60941-76-6
Chemical Structure
1-Benzyl-I3C
- CAS No.: 60941-76-6
- Formula:C16H15NO
- Molecular Weight:237.30
IUPAC Name: (1-benzyl-1H-indol-3-yl)methanol
InChIKey: DXCRDLUQTDLMKZ-UHFFFAOYSA-N
SMILES: OCC1=CN(CC2=CC=CC=C2)C3=C1C=CC=C3
Biological Activity: 1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-Benzyl-I3C | 99.68% | 1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1. | ||||||||||||||||||||
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Keywords
