1 Result for "

89353-99-1

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "89353-99-1" in MCE Product Catalog:

Chiisanogenin
Chiisanogenin
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Cat. No.: HY-N20708
CAS No.: 89353-99-1
Category:  

Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Steroids

Target:  

PI3K Akt NOD-like Receptor (NLR) Pyroptosis PKA GLUT

Chiisanogenin is an orally active triterpenoid. Chiisanogenin reduces postprandial blood glucose by promoting GLUT4 translocation and glucose uptake via activation of the IRS-1/PI3K/Akt signaling pathway. Chiisanogenin binds to MLKL and inhibits its phosphorylation and oligomerization, maintains lysosomal integrity, restores autophagic flux, and suppresses NLRP3 inflammasome activation and pyroptosis. Chiisanogenin inhibits xanthine oxidase activity and regulates oxidative stress and ion pump activity. Chiisanogenin binds to or inhibits PKA, H +/K +-ATPase and β-glucuronidase. Chiisanogenin possesses multiple pharmacological activities, including broad-spectrum antibacterial activity, anticancer, anti-inflammatory, antirheumatic, renoprotective, cardioprotective and antiarrhythmic effects. Chiisanogenin can be used in research related to type 2 diabetes, rheumatoid arthritis, myocardial injury, hepatocellular carcinoma and ventricular arrhythmia .
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