156 Results for "

ALS

" in MedChemExpress (MCE) Product Catalog:
Products (156)

156 Results for "ALS" in MCE Product Catalog:

13
PRE-084 hydrochloride
PRE-084 hydrochloride
0 Images
13 Cited Publications
Cat. No.: HY-18100A
CAS No.: 75136-54-8
Target:  

Sigma Receptor Akt NO Synthase

Research Areas:  

Cardiovascular Disease Neurological Disease

PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway .
5
NF-κΒ activator 2
NF-κΒ activator 2
0 Images
5 Cited Publications
Cat. No.: HY-134477
CAS No.: 2375281-44-8
Purity:  99.76%
Target:  

NF-κB

Research Areas:  

Neurological Disease

NF-κΒ activator 2 is a potent and orally active NF- B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF- B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) .
3
ALS-8112
ALS-8112
0 Images
3 Cited Publications
Cat. No.: HY-12983
CAS No.: 1445379-92-9
Purity:  99.40%
Target:  

RSV

Research Areas:  

Infection

ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.
2
Allitinib
Allitinib
0 Images
2 Cited Publications
Cat. No.: HY-15375
CAS No.: 897383-62-9
Purity:  99.36%
Synonyms: AST-1306; ALS 1306
Target:  

EGFR

Research Areas:  

Cancer

Allitinib (AST-1306) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib also inhibits ErbB4 with an IC50 of 0.8 nM. Allitinib is an anilino-quinazoline compound and has anti-cancer activity .
2
β-N-methylamino-L-alanine hydrochloride
β-N-methylamino-L-alanine hydrochloride
0 Images
2 Cited Publications
Cat. No.: HY-W015546
CAS No.: 16012-55-8
Synonyms: BMAA hydrochloride
Category:  

Microorganisms Neurological Disease Ketones, Aldehydes, Acids Disease Research Fields

Target:  

Bacterial mGluR PKC

β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. β-N-methylamino-L-alanine hydrochloride activates mGluR3 and inhibits PKC. β-N-methylamino-L-alanine hydrochloride can be used in the research of neurodegenerative diseases and immune diseases .
2
Tofersen sodium
Tofersen sodium
0 Images
2 Cited Publications
Cat. No.: HY-132580A
CAS No.: 1898254-60-8
Purity:  97.19%
Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium
Target:  

SOD

Research Areas:  

Neurological Disease

Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
1
Palmitoylglycine
Palmitoylglycine
0 Images
1 Cited Publications
Cat. No.: HY-W074890
CAS No.: 2441-41-0
Synonyms: N-palmitoyl glycine
Category:  

Human Gut Microbiota Metabolites Microorganisms Neurological Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Calcium Channel NO Synthase

Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .
1
Ulefnersen
Ulefnersen
0 Images
1 Cited Publications
Cat. No.: HY-147410
CAS No.: 2589926-25-8
Synonyms: ION-363
Target:  

DNA/RNA Synthesis

Research Areas:  

Neurological Disease

Ulefnersen (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen can be used in the research of Amyotrophic Lateral Sclerosis (ALS) .
1
Terbuthylazine
Terbuthylazine
0 Images
1 Cited Publications
Cat. No.: HY-B1847
CAS No.: 5915-41-3
Target:  

Environmental Pollutants Acetolactate Synthase (ALS) Herbicide

Research Areas:  

Others

Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein .
1
Lumicitabine
Lumicitabine
0 Images
1 Cited Publications
Cat. No.: HY-12983A
CAS No.: 1445385-02-3
Purity:  99.93%
Synonyms: ALS-008176; ALS-8176
Target:  

RSV

Research Areas:  

Infection

Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.
1
Ulefnersen sodium
Ulefnersen sodium
0 Images
1 Cited Publications
Cat. No.: HY-147410A
CAS No.: 2589926-27-0
Purity:  94.55%
Synonyms: ION-363 sodium
Target:  

DNA/RNA Synthesis

Research Areas:  

Neurological Disease

Ulefnersen sodium (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen sodium can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen sodium can be used in the research of Amyotrophic Lateral Sclerosis (ALS) .
1
Tadnersen
Tadnersen
0 Images
1 Cited Publications
Cat. No.: HY-132581
CAS No.: 2170507-65-8
Synonyms: BIIB078; IONIS-C9Rx
Target:  

Ras Others

Research Areas:  

Neurological Disease

Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
1
Tadnersen sodium
Tadnersen sodium
0 Images
1 Cited Publications
Cat. No.: HY-132581A
Purity:  90.06%
Synonyms: BIIB078 sodium; IONIS-C9Rx sodium
Target:  

Ras

Research Areas:  

Neurological Disease

Tadnersen sodium, an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
1
Monepantel
Monepantel
0 Images
1 Cited Publications
Cat. No.: HY-14774
CAS No.: 887148-69-8
Purity:  99.98%
Synonyms: AAD1566; NUZ-001
Target:  

mTOR Parasite nAChR Autophagy

Research Areas:  

Infection Neurological Disease Cancer

Monepantel (AAD1566, NUZ-001), an antiparasitic agent, is an orally active mTOR inhibitor. Monepantel triggers autophagy through the deactivation of mTOR/p70S6K signalling pathway. Monepantel is a positive allosteric modulator of a nematode-specific clade of nAChR subunits. Monepantel can be used for the study of amyotrophic lateral sclerosis (ALS) and ovarian cancer .
1
TARDBP Protein, Human (His)
TARDBP Protein, Human (His)
0 Images
1 Cited Publications
Cat. No.: HY-P71788
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ALS10; TAR DNA binding protein 43; TAR DNA binding protein; TAR DNA-binding protein 43; TARDBP; TDP 43; TDP-43; TDP43
Species:  
Human
Source:  
E. coli
1
P110 heptapeptide
P110 heptapeptide
0 Images
1 Cited Publications
Cat. No.: HY-P10368
CAS No.: 1411976-18-5
Target:  

Dynamin Reactive Oxygen Species (ROS)

Research Areas:  

Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology

P110 heptapeptide is a peptide inhibitor of the Drp1-Fis1 interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of Drp1, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases .
GNE-8505
GNE-8505
0 Images
Cat. No.: HY-114332
CAS No.: 1620573-48-9
Purity:  99.86%
Target:  

MAP3K JNK

Research Areas:  

Neurological Disease Metabolic Disease

GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase (DLK) inhibitor. GNE-8505 has an IC50 of 0.144 μM for pJNK, and EC50 of 0.457 μM for DRG. GNE-8505 inhibits the DLK/JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimer's disease and amyotrophic lateral sclerosis (ALS) .
Imazamox
Imazamox
0 Images
Cat. No.: HY-100427
CAS No.: 114311-32-9
Purity:  99.78%
Synonyms: CL29926; (±)-Imazamox
Target:  

Environmental Pollutants Acetolactate Synthase (ALS)

Research Areas:  

Others

Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .
ATF4-IN-1
ATF4-IN-1
0 Images
Cat. No.: HY-158201
CAS No.: 2991057-76-0
Purity:  99.29%
Target:  

Eukaryotic Initiation Factor (eIF)

Research Areas:  

Neurological Disease

ATF4-IN-1 (Compound 21) is an ATF4 inhibitor and also an eIF2B activator. ATF4-IN-1 can be used in research on neurodegenerative diseases .
BSc5367
BSc5367
0 Images
Cat. No.: HY-144425
CAS No.: 3029584-84-4
Purity:  98.65%
Target:  

NEKs

Research Areas:  

Inflammation/Immunology

BSc5367 is a potent Nek1 inhibitor with an IC50 of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer .
Assay Types