Tadnersen
Based on 1 publication(s) in Google Scholar
Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion.
For research use only. We do not sell to patients.
- Purity : 99.30%
- CAS No.: 2170507-65-8
- Molecular Weight:6481.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Tadnersen
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Biological Activity
Description
In Vitro
Tadnersen (BIIB078) is an RNAse H oligomer that selectively inhibits mutant C9ORF72 transcripts. Tadnersen is used for the research of Amyotrophic Lateral Sclerosis (ALS)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2170507-65-8
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Appearance Solid
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Molecular Weight 6481.30
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Color White to off-white
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SMILES
[Tadnersen]
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Synonyms
BIIB078; IONIS-C9Rx
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Sequence
RNA, ([2′-O-(2-methoxyethyl)]G-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-sp-m5dC-sp-dT-sp-dA-sp-dG-sp-m5dC-sp-dG-sp-m5dC-sp-dG-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]G-[2′-O-(2-methoxyethyl)]A-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5U-sp-[2′-O-(2-methoxyethyl)]m5C) (ACI)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
2025 Nov 13;188(23):6424-6435.e17. PMID: 40865525
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (15.43 mM)
* "≥" means soluble, but saturation unknown.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2242 KB)
References
[1]. Smeyers J, et al. C9ORF72: What It Is, What It Does, and Why It Matters. Front Cell Neurosci. 2021;15:661447. Published 2021 May 5. [Content Brief]
[2]. Aoki Y, et al. Emerging Oligonucleotide Therapeutics for Rare Neuromuscular Diseases [published online ahead of print, 2021 Jun 3]. J Neuromuscul Dis. 2021;10.3233/JND-200560. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.1543 mL | 0.7715 mL | 1.5429 mL | 3.8573 mL |
| 5 mM | 0.0309 mL | 0.1543 mL | 0.3086 mL | 0.7715 mL | |
| 10 mM | 0.0154 mL | 0.0771 mL | 0.1543 mL | 0.3857 mL | |
| 15 mM | 0.0103 mL | 0.0514 mL | 0.1029 mL | 0.2572 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.