Tadnersen
Based on 1 publication(s) in Google Scholar
Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 2170507-65-8
- Molecular Weight:6481.30
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tadnersen
More
Biological Activity
Tadnersen (BIIB078) is an RNAse H oligomer that selectively inhibits mutant C9ORF72 transcripts. Tadnersen is used for the research of Amyotrophic Lateral Sclerosis (ALS)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2170507-65-8
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Appearance Solid
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Molecular Weight 6481.30
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Color White to off-white
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SMILES
[Tadnersen]
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Synonyms
BIIB078; IONIS-C9Rx
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Sequence
RNA, ([2′-O-(2-methoxyethyl)]G-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-sp-m5dC-sp-dT-sp-dA-sp-dG-sp-m5dC-sp-dG-sp-m5dC-sp-dG-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]G-[2′-O-(2-methoxyethyl)]A-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5U-sp-[2′-O-(2-methoxyethyl)]m5C) (ACI)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
2025 Nov 13;188(23):6424-6435.e17. PMID: 40865525
Solvent & Solubility
H2O : ≥ 100 mg/mL (15.43 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2242 KB)
References
[1]. Smeyers J, et al. C9ORF72: What It Is, What It Does, and Why It Matters. Front Cell Neurosci. 2021;15:661447. Published 2021 May 5. [Content Brief]
[2]. Aoki Y, et al. Emerging Oligonucleotide Therapeutics for Rare Neuromuscular Diseases [published online ahead of print, 2021 Jun 3]. J Neuromuscul Dis. 2021;10.3233/JND-200560. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.1543 mL | 0.7715 mL | 1.5429 mL | 3.8573 mL |
| 5 mM | 0.0309 mL | 0.1543 mL | 0.3086 mL | 0.7715 mL | |
| 10 mM | 0.0154 mL | 0.0771 mL | 0.1543 mL | 0.3857 mL | |
| 15 mM | 0.0103 mL | 0.0514 mL | 0.1029 mL | 0.2572 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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