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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
AZA
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "AZA" in MCE Product Catalog:
177
177 Publications Verification
Synonyms: 5-AZA-2'-deoxycytidine; 5-AZA-CdR; NSC 127716
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Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity .
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9 Cited Publications
Synonyms: BMS-247550; AZA-epothilone B
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Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.
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8 Cited Publications
RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor .
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1 Cited Publications
Synonyms: Rac1/Cdc42-IN-1
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion .
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1 Cited Publications
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5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides .
Cat. No.: HY-W007656
CAS No.: 294-90-6
Category:
Natural Products Other Diseases Plants Disease Research Fields Menispermaceae Stephania japonica (Thunb.) Miers
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Synonyms: 5-AZA-T-dCyd; NTX-301
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5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects .
Synonyms: 5-AZA-2'-deoxycytidine (Standard); 5-AZA-CdR (Standard); NSC 127716 (Standard)
Research Areas:
Decitabine (Standard) is the analytical standard of Decitabine. This product is intended for research and analytical applications. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .
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Bromonitromethane is a halogenated nitromethane disinfection byproduct. Bromonitromethane does not induce morphological changes in lung cells, alter cell growth status, change the secretion levels of matrix metalloproteinases, or enhance the anchorage-independent growth ability of lung cells. Bromonitromethane can act as a bromine donor to participate in the bis (amidine)-catalyzed enantioselective aza-Henry addition reaction of N-(trimethylsilyl) imines, which is used in the synthesis of α-bromonitroalkane donors for umpolung amide synthesis (UmAS). Bromonitromethane can be used in bronchial and cancer research .
Cat. No.: HY-D2864
Cat. No.: HY-50071
CAS No.: 211555-30-5
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6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine .
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MNITMT is a more potent immunosuppressive agent without bone marrow toxicity .
AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts. AZA197 can be used for the study of colon cancer .
Cat. No.: HY-124844
CAS No.: 1448460-87-4
Synonyms: AZA-9
Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression .
Cat. No.: HY-W020445
CAS No.: 181873-33-6
Synonyms: 3-Bromo-7-AZA-bicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester
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7-(tert-Butyl) 2-methyl 3-bromo-7-azabicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylate (3-Bromo-7-aza-bicyclo[2.2.1]hepta-2,5-diene-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester) is a drug intermediate for synthesis of various active compounds.
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8-Aza-2’-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
Cat. No.: HY-P4693
CAS No.: 184686-52-0
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Cat. No.: HY-177020
CAS No.: 1191237-49-6
Synonyms: 1'-Cyano-2'-C-methyl 4-AZA-7,9-dideAZA adenosine
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GS-6620 PM (Compound 2) is an analog of 2′-C-methyl 4-aza-7,9-dideaza adenosine. 2′-C-methyl 4-aza-7,9-dideaza adenosine is an inhibitor of HCV replication in cell culture. GS-6620 PM can be used in the study of hepatitis C virus (HCV) infection .
Cat. No.: HY-151763
CAS No.: 2098496-88-7
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Boc-L-Aza-OH CHA is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
