5-Aza-7-deazaguanine

Name: 5-Aza-7-deazaguanine
Brand: MedChemExpress
SKU: HY-111627
Rating: 4.5 (1 reviews)

Cat. No.: HY-111627 Pureza: 99.86%: Ficha de datos
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5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides.

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5-Aza-7-deazaguanine Estructura química

No. CAS : 67410-64-4

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE 5-Aza-7-deazaguanine

•Theranostics. 2021 Jan 1;11(2):841-860. [Abstract]

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Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides^[1].

IC₅₀ & Target

Purine nucleoside phosphorylase, Nucleoside Antimetabolite/Analog^[1]

Peso molecular

151.13

Fòrmula

C₅H₅N₅O

No. CAS

67410-64-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N=C(N)N=C2N1C=CN2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

H₂O : 5 mg/mL (33.08 mM; ultrasonic and adjust pH to 9 with NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6168 mL	33.0841 mL	66.1682 mL
5 mM	1.3234 mL	6.6168 mL	13.2336 mL
10 mM	0.6617 mL	3.3084 mL	6.6168 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.86%

Select Batch:

Ficha de datos (272 KB) SDS (252 KB)

COA (249 KB) RP-HPLC (254 KB) MS (68 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Fateev IV, et al. Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides. Chemistry. 2015 Sep 14;21(38):13401-19. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.6168 mL	33.0841 mL	66.1682 mL	165.4205 mL
	5 mM	1.3234 mL	6.6168 mL	13.2336 mL	33.0841 mL
	10 mM	0.6617 mL	3.3084 mL	6.6168 mL	16.5420 mL
	15 mM	0.4411 mL	2.2056 mL	4.4112 mL	11.0280 mL
	20 mM	0.3308 mL	1.6542 mL	3.3084 mL	8.2710 mL
	25 mM	0.2647 mL	1.3234 mL	2.6467 mL	6.6168 mL
	30 mM	0.2206 mL	1.1028 mL	2.2056 mL	5.5140 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.