117-34-0
Chemical Structure
Diphenylacetic acid
Synonym(s): Diphenylmethane-α-carboxylic Acid
- CAS No.: 117-34-0
- Formula:C14H12O2
- Molecular Weight:212.25
IUPAC Name: 2,2-diphenylacetic acid
InChIKey: PYHXGXCGESYPCW-UHFFFAOYSA-N
SMILES: O=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2
Biological Activity: Diphenylacetic acid (Diphenylmethane-α-carboxylic Acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Diphenylacetic acid can be used as a reagent in the kinetic resolution of racemic 2-hydroxy-y-butyrolactones by asymmetric esterification in the presence of pivalic anhydride and chiral acyl-transfer catalyst. Diphenylacetic acid can act as a catalyst to synthesize 2-allyl-3-oxazolin-5-one derivatives via Rh-catalyzed coupling reaction of azlactones and alkynes followed by aza-Cope rearrangement[1][2][3][4].
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Diphenylacetic acid | 99.81% | Diphenylacetic acid (Diphenylmethane-α-carboxylic Acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Diphenylacetic acid can be used as a reagent in the kinetic resolution of racemic 2-hydroxy-y-butyrolactones by asymmetric esterification in the presence of pivalic anhydride and chiral acyl-transfer catalyst. Diphenylacetic acid can act as a catalyst to synthesize 2-allyl-3-oxazolin-5-one derivatives via Rh-catalyzed coupling reaction of azlactones and alkynes followed by aza-Cope rearrangement. | ||||||||||||||||||||
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- [1]. Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037.
- [2]. Nakata, K., et al., (2013). Kinetic resolution of racemic 2-hydroxy-γ-butyrolactones by asymmetric esterification using diphenylacetic acid with pivalic anhydride and a chiral acyl-transfer catalyst. Organic letters, 15(6), 1170–1173. [Content Brief]
- [3]. Rajkumar, S., et al., (2015). Ru(II)-Catalyzed β-Carboline Directed C-H Arylation and Isolation of Its Cycloruthenated Intermediates. The Journal of organic chemistry, 80(11), 5532–5545. [Content Brief]
- [4]. Kuang, J., et al., (2017). Rhodium-Catalyzed Regioselective Domino Azlactone-Alkyne Coupling/Aza-Cope Rearrangement: Facile Access to 2-Allyl-3-oxazolin-5-ones and Trisubstituted Pyridines. Angewandte Chemie (International ed. in English), 56(29), 8422–8425. [Content Brief]
Keywords
