Cyclen
Based on 1 Customer Validation
Cyclen is a macrocyclic tetraamine chelating agent. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li+/Mg2+ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li+ ions[1][2].
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 294-90-6
- Formula: C8H20N4
- Molecular Weight:172.28
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
5 μM
Compound: 8
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Cytotoxicity against HEK cells
Cytotoxicity against HEK cells
|
[PMID: 18313921] |
Cyclen binds dehydrated Li+ with an adsorption energy of -75.0 kJ/mol, forming a stable complex due to a well-matched molecular cavity size[2].
Cyclen in PEI/Cyclen-TMC composite membrane reduces the Mg2+/Li+ mass ratio of simulated salt lake brine from 40 to 0.3 over three nanofiltration stages, achieving a 45.5% Li+ recovery rate and producing Li2CO3 with 93% purity after precipitation and filtration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 294-90-6
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Appearance Solid
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Molecular Weight 172.28
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Formula C8H20N4
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Color White to off-white
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SMILES
C1CNCCNCCNCCN1
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H2O : 50 mg/mL (290.23 mM; Need ultrasonic)
DMSO : 1.85 mg/mL (10.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (786 KB)
- English - EN (786 KB)
- Français - FR (786 KB)
- Deutsch - DE (786 KB)
- Norwegian - NO (786 KB)
- Español - ES (786 KB)
- Swedish - SV (786 KB)
- Italian - IT (786 KB)
- Korean - KR (786 KB)
- Portuguese - PT (786 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.8045 mL | 29.0225 mL | 58.0450 mL | 145.1126 mL |
| 5 mM | 1.1609 mL | 5.8045 mL | 11.6090 mL | 29.0225 mL | |
| 10 mM | 0.5805 mL | 2.9023 mL | 5.8045 mL | 14.5113 mL | |
| H2O | 15 mM | 0.3870 mL | 1.9348 mL | 3.8697 mL | 9.6742 mL |
| 20 mM | 0.2902 mL | 1.4511 mL | 2.9023 mL | 7.2556 mL | |
| 25 mM | 0.2322 mL | 1.1609 mL | 2.3218 mL | 5.8045 mL | |
| 30 mM | 0.1935 mL | 0.9674 mL | 1.9348 mL | 4.8371 mL | |
| 40 mM | 0.1451 mL | 0.7256 mL | 1.4511 mL | 3.6278 mL | |
| 50 mM | 0.1161 mL | 0.5805 mL | 1.1609 mL | 2.9023 mL | |
| 60 mM | 0.0967 mL | 0.4837 mL | 0.9674 mL | 2.4185 mL | |
| 80 mM | 0.0726 mL | 0.3628 mL | 0.7256 mL | 1.8139 mL | |
| 100 mM | 0.0580 mL | 0.2902 mL | 0.5805 mL | 1.4511 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cyclen Related Classifications
HY-W007656 Related Classifications
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