563-70-2
Chemical Structure
Bromonitromethane
- CAS 番号: 563-70-2
- Formula:CH2BrNO2
- Molecular Weight:139.94
IUPAC Name: bromo(nitro)methane
InChIKey: DNPRVXJGNANVCZ-UHFFFAOYSA-N
SMILES: O=[N+](CBr)[O-]
Biological Activity: Bromonitromethane is a halogenated nitromethane disinfection byproduct. Bromonitromethane does not induce morphological changes in lung cells, alter cell growth status, change the secretion levels of matrix metalloproteinases, or enhance the anchorage-independent growth ability of lung cells. Bromonitromethane can act as a bromine donor to participate in the bis (amidine)-catalyzed enantioselective aza-Henry addition reaction of N-(trimethylsilyl) imines, which is used in the synthesis of α-bromonitroalkane donors for umpolung amide synthesis (UmAS). Bromonitromethane can be used in bronchial and cancer research[1][2][3].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Bromonitromethane | 99.38% | Bromonitromethane is a halogenated nitromethane disinfection byproduct. Bromonitromethane does not induce morphological changes in lung cells, alter cell growth status, change the secretion levels of matrix metalloproteinases, or enhance the anchorage-independent growth ability of lung cells. Bromonitromethane can act as a bromine donor to participate in the bis (amidine)-catalyzed enantioselective aza-Henry addition reaction of N-(trimethylsilyl) imines, which is used in the synthesis of α-bromonitroalkane donors for umpolung amide synthesis (UmAS). Bromonitromethane can be used in bronchial and cancer research. | ||||||||||||||||||||
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References
- [1]. Marsà A, et al. In vitro studies on the tumorigenic potential of the halonitromethanes trichloronitromethane and bromonitromethane. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Dec;45(Pt 1):72-80. [Content Brief]
- [2]. Makley DM, et al. Silyl imine electrophiles in enantioselective catalysis: a Rosetta Stone for peptide homologation, enabling diverse N-protected aryl glycines from aldehydes in three steps. Organic letters. 2014 Jun 06;16(11):3146-9. [Content Brief]
- [3]. Zhang J. Bromonitromethane: A Versatile Reagent in Organic Synthesis[J]. Synlett, 2009, 2009(10): 1692-1693.
