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AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman (AngiotensinII) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman acetate also induces apoptosis. AngiotensinIIhuman acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) is a mouse-derived Osteopontin/SPP1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) blocks AngiotensinII (HY-13948)-induced DNA synthesis and collagen gel contraction in cardiac fibroblasts. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) significantly inhibits tumor growth in CT26 or MC38 tumors mice models .
Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman TFA also induces apoptosis. AngiotensinIIhuman TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC50 of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats .
3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α1-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis .
AngiotensinII (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensinII . AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
Biotin-Ahx-AngiotensinIIhuman (Biotin-Ahx-AngiotensinII; Biotin-Ahx-Ang II; Biotin-Ahx-DRVYIHPF) is a biological active peptide. (biotin labeled HY-13948)
Losartan-d4 carboxylic acid (E-3174-d4) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
TRV055 (TRV120055) is a G protein-biased agonist of angiotensinII type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1]
AngiotensinIIhuman- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinIIhuman (TFA) (HY-13948B). AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
TRV055 (TRV120055) hydrochloride is a G protein-biased agonist of angiotensinII type 1 receptors (AT1Rs). TRV055 hydrochloride induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. RV055 hydrochloride activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. RV055 hydrochloride induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. RV055 hydrochloride can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1]
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensinII and is cleaved into angiotensinII by angiotensin converting enzyme (ACE) .
AngiotensinII (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
AngiotensinII (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
L-162537 is a competitive humanangiotensinII receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensinII-related cardiovascular diseases such as hypertension .
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensinII AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes .
Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensinII, cleaved by the angiotensin-converting enzyme (ACE) .
Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan (mesylate) (Standard) is the analytical standard of Eprosartan (mesylate). This product is intended for research and analytical applications. Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan (Standard) is the analytical standard of Eprosartan. This product is intended for research and analytical applications. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan-d6 is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure [4].
L-163958 is an efficient, orally active, balanced angiotensinII receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases .
VTP-27999 Hydrochloride is an orally active renin inhibitor. VTP-27999 Hydrochloride functionally inhibits renin and acid-activated prorenin, suppresses plasma renin activity and modulates plasma and urinary aldosterone levels. VTP-27999 Hydrochloride reduces mean arterial blood pressure, induces plasma renin concentration increases, decreases plasma angiotensin II levels and enhances renin immunoreactivity. VTP-27999 (Hydrochloride) can be used for the research of hypertension and chronic renal disease .
L-162782 is a high affinity AT1 receptor ligand for rat and human wild-type AT1 with IC50 values of 28.5 and 24.6 nM, respectively. L-162782 acts as a partial agonist (EC50 ≈ 30 nM) and insurmountable antagonist (IC50 = 6.5 μM) on wild-type rat AT1 receptors in COS-7 cells. L-162782 reduces AngiotensinII (HY-13948)-induced phosphatidylinositol turnover. L-162782 can be used for hypertension research .
Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions .
AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman (AngiotensinII) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman acetate also induces apoptosis. AngiotensinIIhuman acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman TFA also induces apoptosis. AngiotensinIIhuman TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC50 of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats .
AngiotensinII (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensinII . AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
Biotin-Ahx-AngiotensinIIhuman (Biotin-Ahx-AngiotensinII; Biotin-Ahx-Ang II; Biotin-Ahx-DRVYIHPF) is a biological active peptide. (biotin labeled HY-13948)
TRV055 (TRV120055) is a G protein-biased agonist of angiotensinII type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1]
AngiotensinIIhuman- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinIIhuman (TFA) (HY-13948B). AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
TRV055 (TRV120055) hydrochloride is a G protein-biased agonist of angiotensinII type 1 receptors (AT1Rs). TRV055 hydrochloride induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. RV055 hydrochloride activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. RV055 hydrochloride induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. RV055 hydrochloride can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1]
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensinII and is cleaved into angiotensinII by angiotensin converting enzyme (ACE) .
AngiotensinII (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
AngiotensinII (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensinII, cleaved by the angiotensin-converting enzyme (ACE) .
Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) is a mouse-derived Osteopontin/SPP1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) blocks AngiotensinII (HY-13948)-induced DNA synthesis and collagen gel contraction in cardiac fibroblasts. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) significantly inhibits tumor growth in CT26 or MC38 tumors mice models .
AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α1-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis .
AGTR2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
Losartan-d4 carboxylic acid (E-3174-d4) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
AngiotensinIIhuman- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinIIhuman (TFA) (HY-13948B). AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensinII and is cleaved into angiotensinII by angiotensin converting enzyme (ACE) .
Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan-d6 is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
AG2S, Agtr 1, Agtr1, AGTR1_human, Agtr1a, AGTR1B, Ang II, AngiotensinII receptor type 1, AngiotensinII type-1 receptor, Angiotensin receptor 1
WB, ICC/IF, FC
Human, Mouse, Rat
Angiotensin II Type 1 Receptor Antibody (YA9721) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Angiotensin II Type 1 Receptor.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
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