115102-72-2
115102-72-2
Chemical Structure
Biotin-Ahx-Angiotensin II human
Synonym(s): Biotin-Ahx-Angiotensin II; Biotin-Ahx-Ang II; Biotin-Ahx-DRVYIHPF
- CAS No.: 115102-72-2
- Formula:C66H96N16O15S
- Molecular Weight:1385.63
InChIKey: DIRDWKYAFGQYKD-UTBCTFNGSA-N
SMILES: [H][C@@]12[C@@](CS[C@H]2CCCCC(NCCCCCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CNC=N4)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([H])NC(N1)=O
Biological Activity: Biotin-Ahx-Angiotensin II human (Biotin-Ahx-Angiotensin II; Biotin-Ahx-Ang II; Biotin-Ahx-DRVYIHPF) is a biological active peptide. (biotin labeled HY-13948)
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Biotin-Ahx-Angiotensin II human | 99.86% | Biotin-Ahx-Angiotensin II human (Biotin-Ahx-Angiotensin II; Biotin-Ahx-Ang II; Biotin-Ahx-DRVYIHPF) is a biological active peptide. (biotin labeled HY-13948) | ||||||||||||||||||||
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Angiotensin II human | 99.98% | Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. | ||||||||||||||||||||
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Angiotensin II human acetate | 99.80% | Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. | ||||||||||||||||||||
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Angiotensin II 5-valine | 99.35% | Angiotensin II 5-valine is an agonist of angiotensin receptor. | ||||||||||||||||||||
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Angiotensin I (human, mouse, rat) | 99.70% | Angiotensin I is a decapeptide hormone. Angiotensin I is the precursor of Angiotensin II (HY-13948). Angiotensin I can be used in the study of cardiovascular diseases such as hypertension and vasospasm. | ||||||||||||||||||||
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Biotinyl-Angiotensin I (human, mouse, rat) | Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE). | |||||||||||||||||||||
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AT1R-agonist-1 | AT1R-agonist-1 is an angiotensin II type 1 receptor (AT1R) agonist with a Ki value of 1.4 nM. AT1R-agonist-1 exhibits low Gαq activity, retains β-arrestin recruitment function, and accesses the deep allosteric pocket inside AT1R via its flexible side chain. AT1R-agonist-1 possesses positive inotropic effects (enhancing cardiac contractile function) and causes almost no increase in blood pressure. AT1R-agonist-1 can be used for research on conditions such as refractory cardiogenic shock. | |||||||||||||||||||||
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[Tyr(P)4] Angiotensin II | [Tyr(P)4] Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels. | |||||||||||||||||||||
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Crinia-angiotensin II | Crinia-angiotensin II is a potent neuropeptide. Crinia-angiotensin II can be isolated from Crinia Georgiana. Crinia-angiotensin II can be hydrolyzed by SedB (a tripeptidyl peptidase). | |||||||||||||||||||||
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Des-Leu10-angiotensin I | Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell. | |||||||||||||||||||||
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TRV056 | 98.06% | TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists. | ||||||||||||||||||||
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