1. GPCR/G Protein
  2. Angiotensin Receptor
  3. TRV056

TRV056 

Cat. No.: HY-P3137
Handling Instructions

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists.

For research use only. We do not sell to patients.

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TRV056 Chemical Structure

TRV056 Chemical Structure

CAS No. : 812644-79-4

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Description

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].

In Vitro

TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1103.23

Formula

C₅₂H₇₄N₁₄O₁₃

CAS No.

812644-79-4

Sequence Shortening

DRGVYIHPF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TRV056TRV 056TRV-056Angiotensin ReceptorAT1RGPCRGq-biasedligandInhibitorinhibitorinhibit

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TRV056
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HY-P3137
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