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Apis mellifera

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Calcium Channel (1) Drug Derivative (1) Herbicide (1) Insecticide (3) nAChR (1) Parasite (1) Reactive Oxygen Species (ROS) (2)
By Research Areas:	Endocrinology (1) Infection (3) Metabolic Disease (3) Neurological Disease (1)

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Peptides

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Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-128030

Makisterone A	Others	Endocrinology
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

HY-N8491A

(+)-Dihydrocarvone	Others	Others
(+)-Dihydrocarvone elicits strong antennal responses of A. mellifera. (+)-Dihydrocarvone influences bee foraging preference for tomato .

HY-W339331

Flubendiamide NNI-0001	Insecticide Calcium Channel Reactive Oxygen Species (ROS) Apoptosis	Infection Metabolic Disease
Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis .

HY-B2021

τ-Fluvalinate	Insecticide	Neurological Disease
τ-Fluvalinate is an insecticide and in-hive miticide, with its mechanism involving interfering with nervous systems. τ-Fluvalinate binds to the open state of Varroa destructor (VdNaV1) and Apis mellifera (AmNaV1) voltage-dependent sodium channels, with EC₅₀ values of 160 nM and 60 nM respectively. τ-Fluvalinate has higher affinity for AmNaV1, which causes sublethal toxicity to honeybees. τ-Fluvalinate can be applied for research on Varroa destructor infestation in honeybee colonies .

HY-W714006

Cochliodinol	Reactive Oxygen Species (ROS)	Metabolic Disease
Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC₅₀=3.06 μg/mL) .

HY-B0827B

(S)-Dinotefuran (S)-MTI-446	nAChR Parasite	Infection
(S)-Dinotefuran ((S)-MTI-446), a neonicotinoid pesticide, is toxic by binding to α8 subunit of nAChR of honeybee Apis mellifera (Apis mellifera Linnaeus). (S)-Dinotefuran shows more toxic than R-dinotefuran to honeybee Apis mellifera .

HY-P3029D

*Phospholipase A2, Honey bee venom (Apis* mellifera)**	Biochemical Assay Reagents	Metabolic Disease
Phospholipase A2, Honey bee venom (Apis mellifera) (EC 3.1.1.4) hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues.

HY-W710697

Triclopyr ester Triclopyr 2-butoxyethylester	Herbicide	Others
Triclopyr ester (Triclopyr 2-butoxyethylester) is a bioactive substance with activity in controlling harmful woody plants. Triclopyr ester showed toxicity to honeybees (Apis mellifera) in greenhouse trials. Triclopyr ester in combination with other herbicides is effective in removing the canopy of plants such as honey trees and whitebrush. Triclopyr ester can quickly assess its weeding effectiveness when treating trees in greenhouses, providing potential treatment options for field experiments .

HY-181985

Insecticidal agent 30	Insecticide	Infection
Insecticidal agent 30 is an orally active insecticidal agent. Insecticidal agent 30 induces rapid contact mortality in adult Brassicogethes aeneus, achieves 100% 24-hour contact mortality against Brassicogethes aeneus, and exhibits moderate insecticidal activity against Drosophila melanogaster. Insecticidal agent 30 can be used for the research of pollen beetle (brassicogethes aeneus) infestation .

HY-N18016

4'-Hydroxy-5,7,3'-trimethoxyflavanone Hesperitin-5,7-dimethyl-ether	Drug Derivative	Others
4'-Hydroxy-5,7,3'-trimethoxyflavanone (Hesperitin-5,7-dimethyl-ether) (Compound 13) is an O-methylated flavanone and a derivative of Hesperetin (HY-N0168) .

Cat. No.	상품명	Target	Research Area

HY-P4851

Adipokinetic hormone (Manduca sexta) Manse-AKH	Peptides	Others
Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta) is a common peptide among various insects. Adipokinetic Hormone induces strong adipokinetic/hypertrehalosemic response. However Adipokinetic Hormone has no a glycogen-mobilizing function nor an adequate glycogen store in fat body for its effective utilization .

Makisterone A	Classification of Application Fields Chenopodium quinoa Willd. Plants Disease Research Fields Endocrinology Steroids Source Classification Chenopodiaceae	Others
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

(+)-Dihydrocarvone	Structural Classification Endopappus macrocarpus Sch.Bip. Terpenoids Labiatae Sesquiterpenes Plants Source Classification	Others
(+)-Dihydrocarvone elicits strong antennal responses of A. mellifera. (+)-Dihydrocarvone influences bee foraging preference for tomato .

Cochliodinol	Human Gut Microbiota Metabolites Microorganisms Antibiotics Endogenous metabolite Other Antibiotics Source Classification	Reactive Oxygen Species (ROS)
Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC₅₀=3.06 μg/mL) .

4'-Hydroxy-5,7,3'-trimethoxyflavanone Hesperitin-5,7-dimethyl-ether	Structural Classification Flavonoids Animals Flavonones Source Classification	Drug Derivative
4'-Hydroxy-5,7,3'-trimethoxyflavanone (Hesperitin-5,7-dimethyl-ether) (Compound 13) is an O-methylated flavanone and a derivative of Hesperetin (HY-N0168) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Apis mellifera

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
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