τ-Fluvalinate
Based on 1 Customer Validation
τ-Fluvalinate is an insecticide and in-hive miticide, with its mechanism involving interfering with nervous systems. τ-Fluvalinate binds to the open state of Varroa destructor (VdNaV1) and Apis mellifera (AmNaV1) voltage-dependent sodium channels, with EC50 values of 160 nM and 60 nM respectively. τ-Fluvalinate has higher affinity for AmNaV1, which causes sublethal toxicity to honeybees. τ-Fluvalinate can be applied for research on Varroa destructor infestation in honeybee colonies.
For research use only. We do not sell to patients.
- Purity: 98.32%
- CAS No.: 102851-06-9
- Formula: C26H22ClF3N2O3
- Molecular Weight:502.91
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
τ-Fluvalinate (1 nM-10 μM) modifies heterologously expressed AmNaV1 channels with higher affinity (EC50 = 60 nM) and greater maximal effect than VdNaV1 channels (EC50 = 160 nM) in Xenopus laevis oocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 102851-06-9
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Appearance Oil
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Molecular Weight 502.91
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Formula C26H22ClF3N2O3
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Color Colorless to light yellow
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SMILES
ClC(C=C(C=C1)C(F)(F)F)=C1N[C@H](C(C)C)C(OC(C2=CC(OC3=CC=CC=C3)=CC=C2)C#N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (198.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (276 KB)
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SDS (625 KB)
- English - EN (625 KB)
- Français - FR (625 KB)
- Deutsch - DE (625 KB)
- Norwegian - NO (625 KB)
- Español - ES (625 KB)
- Swedish - SV (625 KB)
- Italian - IT (625 KB)
- Portuguese - PT (625 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang J, et al. A Novel Sensitive Luminescence Probe Microspheres for Rapid and Efficient Detection of τ-Fluvalinate in Taihu Lake. Sci Rep. 2017;7:46635. Published 2017 May 9. [Content Brief]
[2]. Gosselin-Badaroudine P, et al. Biophysical characterization of the Varroa destructor NaV1 sodium channel and its affinity for τ-fluvalinate insecticide. FASEB J. 2017 Jul;31(7):3066-3071. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9884 mL | 9.9421 mL | 19.8843 mL | 49.7107 mL |
| 5 mM | 0.3977 mL | 1.9884 mL | 3.9769 mL | 9.9421 mL | |
| 10 mM | 0.1988 mL | 0.9942 mL | 1.9884 mL | 4.9711 mL | |
| 15 mM | 0.1326 mL | 0.6628 mL | 1.3256 mL | 3.3140 mL | |
| 20 mM | 0.0994 mL | 0.4971 mL | 0.9942 mL | 2.4855 mL | |
| 25 mM | 0.0795 mL | 0.3977 mL | 0.7954 mL | 1.9884 mL | |
| 30 mM | 0.0663 mL | 0.3314 mL | 0.6628 mL | 1.6570 mL | |
| 40 mM | 0.0497 mL | 0.2486 mL | 0.4971 mL | 1.2428 mL | |
| 50 mM | 0.0398 mL | 0.1988 mL | 0.3977 mL | 0.9942 mL | |
| 60 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8285 mL | |
| 80 mM | 0.0249 mL | 0.1243 mL | 0.2486 mL | 0.6214 mL | |
| 100 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4971 mL |
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