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  4. τ-Fluvalinate

τ-Fluvalinate is an insecticide and in-hive miticide, with its mechanism involving interfering with nervous systems. τ-Fluvalinate binds to the open state of Varroa destructor (VdNaV1) and Apis mellifera (AmNaV1) voltage-dependent sodium channels, with EC50 values of 160 nM and 60 nM respectively. τ-Fluvalinate has higher affinity for AmNaV1, which causes sublethal toxicity to honeybees. τ-Fluvalinate can be applied for research on Varroa destructor infestation in honeybee colonies.

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τ-Fluvalinate

τ-Fluvalinate Chemical Structure

CAS No. : 102851-06-9

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τ-Fluvalinate Related Antibodies

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Description

τ-Fluvalinate is an insecticide and in-hive miticide, with its mechanism involving interfering with nervous systems. τ-Fluvalinate binds to the open state of Varroa destructor (VdNaV1) and Apis mellifera (AmNaV1) voltage-dependent sodium channels, with EC50 values of 160 nM and 60 nM respectively. τ-Fluvalinate has higher affinity for AmNaV1, which causes sublethal toxicity to honeybees. τ-Fluvalinate can be applied for research on Varroa destructor infestation in honeybee colonies[1][2].

In Vitro

τ-Fluvalinate (1 nM-10 μM) modifies heterologously expressed AmNaV1 channels with higher affinity (EC50 = 60 nM) and greater maximal effect than VdNaV1 channels (EC50 = 160 nM) in Xenopus laevis oocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

τ-Fluvalinate Related Antibodies
Molecular Weight

502.91

Formula

C26H22ClF3N2O3
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

ClC(C=C(C=C1)C(F)(F)F)=C1N[C@H](C(C)C)C(OC(C2=CC(OC3=CC=CC=C3)=CC=C2)C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (198.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9884 mL 9.9421 mL 19.8843 mL
5 mM 0.3977 mL 1.9884 mL 3.9769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.15%

SDS (624 KB)

COA (253 KB) HNMR (305 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9884 mL 9.9421 mL 19.8843 mL 49.7107 mL
5 mM 0.3977 mL 1.9884 mL 3.9769 mL 9.9421 mL
10 mM 0.1988 mL 0.9942 mL 1.9884 mL 4.9711 mL
15 mM 0.1326 mL 0.6628 mL 1.3256 mL 3.3140 mL
20 mM 0.0994 mL 0.4971 mL 0.9942 mL 2.4855 mL
25 mM 0.0795 mL 0.3977 mL 0.7954 mL 1.9884 mL
30 mM 0.0663 mL 0.3314 mL 0.6628 mL 1.6570 mL
40 mM 0.0497 mL 0.2486 mL 0.4971 mL 1.2428 mL
50 mM 0.0398 mL 0.1988 mL 0.3977 mL 0.9942 mL
60 mM 0.0331 mL 0.1657 mL 0.3314 mL 0.8285 mL
80 mM 0.0249 mL 0.1243 mL 0.2486 mL 0.6214 mL
100 mM 0.0199 mL 0.0994 mL 0.1988 mL 0.4971 mL
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τ-Fluvalinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

τ-Fluvalinate102851-06-9InsecticideVdNaV1Xenopus laevis oocytesAmNaV1endocrine-disrupting effectsneurodisruptorApis mellifera voltage-dependent sodium channelVarroa destructorApis melliferaVarroa destructor voltage-dependent sodium channelvarroa destructor mite infestationInhibitorinhibitorinhibit

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