69409-94-5
Chemical Structure
Fluvalinate
- CAS 番号: 69409-94-5
- Formula:C26H22ClF3N2O3
- Molecular Weight:502.91
IUPAC Name: cyano(3-phenoxyphenyl)methyl (2-chloro-4-(trifluoromethyl)phenyl)valinate
InChIKey: INISTDXBRIBGOC-UHFFFAOYSA-N
SMILES: CC(C(NC1=CC=C(C=C1Cl)C(F)(F)F)C(OC(C2=CC=CC(OC3=CC=CC=C3)=C2)C#N)=O)C
Biological Activity: Fluvalinate is an orally active acaricide classified as a sodium channel inhibitor. Fluvalinate delays sodium channel closure, prolongs cell membrane depolarization, inhibits the excitability of honeybee brain neurons, and exerts a central nervous system inhibitory effect. Fluvalinate negatively affects the learning ability, memory ability, sucrose responsiveness, and survival of honeybees. Fluvalinate potentiates pentobarbital-induced hypnosis, reduces spontaneous activity in mice, and decreases the total white blood cell count and absolute lymphocyte count in mice. Fluvalinate induces acute toxic symptoms in rats, acts as a cholinergic stimulant, and induces the production of hepatic enzymes in rats. Fluvalinate causes the death of Varroa jacobsoni sensitive to τ-Fluvalinate (HY-B2021). Fluvalinate can be used in studies related to mite pest control[1][2][3][4].
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Fluvalinate | Fluvalinate is an orally active acaricide classified as a sodium channel inhibitor. Fluvalinate delays sodium channel closure, prolongs cell membrane depolarization, inhibits the excitability of honeybee brain neurons, and exerts a central nervous system inhibitory effect. Fluvalinate negatively affects the learning ability, memory ability, sucrose responsiveness, and survival of honeybees. Fluvalinate potentiates pentobarbital-induced hypnosis, reduces spontaneous activity in mice, and decreases the total white blood cell count and absolute lymphocyte count in mice. Fluvalinate induces acute toxic symptoms in rats, acts as a cholinergic stimulant, and induces the production of hepatic enzymes in rats. Fluvalinate causes the death of Varroa jacobsoni sensitive to τ-Fluvalinate (HY-B2021). Fluvalinate can be used in studies related to mite pest control. | |||||||||||||||||||||
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Fluvalinate-d5 | Fluvalinate-d5 is the deuterated-labeled Fluvalinate (HY-123320). Fluvalinate is an orally active acaricide classified as a sodium channel inhibitor. Fluvalinate delays sodium channel closure, prolongs cell membrane depolarization, inhibits the excitability of honeybee brain neurons, and exerts a central nervous system inhibitory effect. Fluvalinate negatively affects the learning ability, memory ability, sucrose responsiveness, and survival of honeybees. Fluvalinate potentiates pentobarbital-induced hypnosis, reduces spontaneous activity in mice, and decreases the total white blood cell count and absolute lymphocyte count in mice. Fluvalinate induces acute toxic symptoms in rats, acts as a cholinergic stimulant, and induces the production of hepatic enzymes in rats. Fluvalinate causes the death of Varroa jacobsoni sensitive to τ-Fluvalinate (HY-B2021). Fluvalinate can be used in studies related to mite pest control. | |||||||||||||||||||||
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References
- [1]. Garg S K, et al. Toxicological Profile of Fluvalinate - A Synthetic Pyrethroid. Indian Journal of Pharmacology, 1992, 24: 154-157.
- [2]. Frost EH, et al. Effects of fluvalinate on honey bee learning, memory, responsiveness to sucrose, and survival. The Journal of experimental biology. 2013 Aug 01;216(Pt 15):2931-8. [Content Brief]
- [3]. Garg S K, et al. Biochemical and physiological alterations following short term exposure to fluvalinate - A synthetic pyrethroid. Indian Journal of Pharmacology, 1997, 29(4): 250-254.
- [4]. Elzen P J, et al. Detection of resistance in US Varroa jacobsoni Oud. (Mesostigmata: Varroidae) to the acaricide fluvalinate. Apidologie, 1999, 30: 13-17.
