272451-65-7
Chemical Structure
Flubendiamide
Synonym(s): NNI-0001
- CAS No.: 272451-65-7
- Formula:C23H22F7IN2O4S
- Molecular Weight:682.39
IUPAC Name: 2-(methylsulfonyl)-1-(pyridin-4-yl)ethan-1-one
InChIKey: ZGNITFSDLCMLGI-UHFFFAOYSA-N
SMILES: O=C(C1=C(C(NC(C)(CS(=O)(C)=O)C)=O)C(I)=CC=C1)NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)F)C=C2C
Biological Activity: Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flubendiamide | 99.42% | Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis. | ||||||||||||||||||||
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Flubendiamide (Standard) | ≥98% | Flubendiamide (Standard) is the analytical standard of Flubendiamide. This product is intended for research and analytical applications. Flubendiamide is a 1,2-diamide insecticide via action mode of action action by activating the ryanodine receptor. | ||||||||||||||||||||
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- [1]. Jameel M, et al. Flubendiamide induced genetic and cellular damages directly influence the life cycle of the oriental leaf worm, Spodoptera litura. Pestic Biochem Physiol. 2023;193:105448. [Content Brief]
- [2]. Kadala A, et al. Flubendiamide, the first phthalic acid diamide insecticide, impairs neuronal calcium signalling in the honey bee's antennae. J Insect Physiol. 2020;125:104086. [Content Brief]
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[3]. Sun Q, et al. Flubendiamide Enhances Adipogenesis and Inhibits AMPKα in 3T3-L1 Adipocytes. Molecules. 2018 Nov 12;23(11):2950.
[Content Brief]
