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Arginase, Human

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arginase (10) Bacterial (2) Reference Standards (2)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (2)

Inhibitors & Agonists

Inhibitory Antibodies

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Recombinant Proteins

Targets Recommended: Arginase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101979

Numidargistat Maximum Cited Publications 12 Publications Verification CB-1158; INCB01158	Arginase	Cancer
Numidargistat (CB-1158) is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human* arginase 1 and recombinant human arginase 2**, respectively. Immuno-oncology agent .

HY-15775

Arginase inhibitor 1 5+ Cited Publications	Arginase	Cancer
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC₅₀s of 223 and 509 nM, respectively.

HY-W062216

2-Aminoimidazole	Bacterial Arginase	Infection
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a K_i of 3.6 mM .

HY-101979A

Numidargistat dihydrochloride Maximum Cited Publications 12 Publications Verification CB-1158 dihydrochloride; INCB01158 dihydrochloride	Arginase	Cancer
Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human* arginase 1 and recombinant human arginase 2**, respectively. Immuno-oncology agent .

HY-173041

Arginase inhibitor 9	Arginase	Inflammation/Immunology
Arginase inhibitor 9 (Compound 12a) is an arginase inhibitor with IC₅₀ values of 9 μM and 55 μM for bovine and human arginase I, respectively. Arginase inhibitor 9 exhibits antioxidant activity and can scavenge free radicals. Additionally, Arginase inhibitor 9 can effectively regulate the levels of collagen and procollagen, exerting an anti-fibrotic effect .

HY-E70951A

**Arginase, Human**	Arginase	Others
Arginase, Human (EC 3.5.3.1) is a manganese-containing enzyme, the last enzyme in the urea cycle, catalyzing the conversion of arginine to ornithine and urea.

HY-W062216R

2-Aminoimidazole (Standard)	Reference Standards Bacterial Arginase	Infection
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM .

HY-P991870

Anti-Arginase-1 Antibody	Arginase	Cancer
Anti-Arginase-1 Antibody is an antibody against human *Arginase-1/ARG1. Recommend Isotype Controls:?Human* IgG1 kappa, Isotype Control (HY-P99001).

HY-101979R

Numidargistat (Standard) CB-1158 (Standard); INCB01158 (Standard)	Reference Standards Arginase	Cancer
Numidargistat (Standard) is the analytical standard of Numidargistat (HY-101979). This product is intended for research and analytical applications. Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent .

HY-182718

AZD0011-PL	Arginase	Inflammation/Immunology Cancer
AZD0011-PL is a human arginase 1/ 2 inhibitor with IC₅₀ values of 0.01 μM and 0.02 μM. AZD0011-PL can be used for the researches of cancer, respiratory inflammatory disease .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991870

Anti-Arginase-1 Antibody	Arginase	Cancer
Anti-Arginase-1 Antibody is an antibody against human *Arginase-1/ARG1. Recommend Isotype Controls:?Human* IgG1 kappa, Isotype Control (HY-P99001).

2-Aminoimidazole	Infection Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Arginase
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a K_i of 3.6 mM .

2-Aminoimidazole (Standard)	Structural Classification Natural Products Animals Source Classification	Reference Standards Bacterial Arginase
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM .

Species:	Human (5)
Tag:	His (5)
Source:	HEK293 (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705455

	Arginase-2/ARG2 Protein, Human (332a.a, His) Arginase-2, mitochondrial; ARG2; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase	Human	E. coli

HY-P7603

	Arginase-2/ARG2 Protein, Human (His) rHuArginase-2, His; ARG2; Arginase-2	Human	E. coli
	Arginase-2/ARG2 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Arginase-2 (Arg2) acts as a fasting-induced hepatocyte factor that protects against hepatic and peripheral fat accumulation, hepatic inflammatory responses, and insulin and glucose intolerance in obese murine models.

HY-P7541

	Arginase-1/ARG1 Protein, Human (C-His) rHuArginase-1, His; ARG1; Arginase-1	Human	E. coli
	Arginase-1 Protein, Human (C-His) expresses in E. coli with a His tag at the C-terminus. Arginase-1 Protein inhibits the growth of the arginine-depleting enzyme arginine deiminase (ADI)-resistant Hep3B tumor cells in mice.

HY-P7541A

	Arginase-1/ARG1 Protein, Human (N-His) rHuArginase-1, His; ARG1; Arginase-1	Human	E. coli
	Arginase-1 (ARG1) protein, crucial in the urea cycle, converts L-arginine to urea and L-ornithine. ARG1 also regulates L-arginine levels outside the liver, impacting immune responses. ARG1's release by granulocytes suppresses T cell and NK cell functions. In ILC2s, ARG1 promotes lung inflammation. However, ARG1's role in human monocytic/macrophage/dendritic cells is unclear. Arginase-1/ARG1 Protein, Human (N-His) is the recombinant human-derived Arginase-1/ARG1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7602

	Arginase-1/ARG1 Protein, Human (HEK293, His) rHuArginase-1, His; ARG1; Arginase-1	Human	HEK293
	Arginase-1 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag at the C-terminus. Arginase-1 Protein inhibits the growth of the arginine-depleting enzyme arginine deiminase (ADI)-resistant Hep3B tumor cells in mice.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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