2095732-06-0
2095732-06-0
Chemical Structure
Numidargistat
Synonym(s): CB-1158; INCB01158
- CAS No.: 2095732-06-0
- Formula:C11H22BN3O5
- Molecular Weight:287.12
IUPAC Name: (3R,4S)-1-(L-alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
InChIKey: ZZJLMZYUGLJBSO-LAEOZQHASA-N
SMILES: O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1
Biological Activity: Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
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Numidargistat | 98.0% | Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent. | ||||||||||||||||||||
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Numidargistat (Standard) | ≥98% | Numidargistat (Standard) is the analytical standard of Numidargistat (HY-101979). This product is intended for research and analytical applications. Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-155108OATD-02 -
Similarity Score 0.64
HY-182719AZD0011 -
Similarity Score 0.63
HY-145331ARG1-IN-1 -
Similarity Score 0.62
HY-182718AZD0011-PL -
Similarity Score 0.60
HY-15775Arginase inhibitor 1 -
Similarity Score 0.60
HY-161061Arginase inhibitor 7 -
Similarity Score 0.59
HY-126332NED-3238 -
Similarity Score 0.57
HY-119060FP0429 -
Similarity Score 0.57
HY-P10391Ser-Ala-Pro -
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