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Cat. No.: HY-145331

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ARG1-IN-1

ARG1-IN-1 (Compound 3) is an orally active arginase inhibitor with an IC₅₀ value of 29 nM. ARG1-IN-1 can inhibit serum arginase activity and increase arginine levels in mouse tumor models. ARG1-IN-1 is applicable for tumor research.

For research use only. We do not sell to patients.

CAS No.: 2376189-62-5
Formula: C₁₁H₂₁BN₂O₄
Molecular Weight:256.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ARG1-IN-1 Chemical Structure

CAS No.: 2376189-62-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
EMT6	IC₅₀	956 nM Compound: 3	Invivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis Invivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis	[PMID: 32292567]
EMT6	IC₅₀	956 nM Compound: 3	In vivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis In vivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis	[PMID: 32292567]

Chemical Information

CAS No. 2376189-62-5
Molecular Weight 256.11
Formula C₁₁H₂₁BN₂O₄
SMILES

OB(O)CCC[C@H]1[C@@]2([H])[C@@](CNC2)([H])C[C@@]1(N)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mitcheltree MJ, et al. Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. ACS Med Chem Lett. 2020 Mar 23;11(4):582-588. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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