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Cat. No.: HY-145331

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ARG1-IN-1

ARG1-IN-1 (Compound 3) is an orally active arginase inhibitor with an IC₅₀ value of 29 nM. ARG1-IN-1 can inhibit serum arginase activity and increase arginine levels in mouse tumor models. ARG1-IN-1 is applicable for tumor research.

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CAS No.: 2376189-62-5
화학식: C₁₁H₂₁BN₂O₄
분자량:256.11

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ARG1-IN-1 Chemical Structure

CAS No.: 2376189-62-5

사이즈

가격

재고

수량

Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
EMT6	IC₅₀	956 nM Compound: 3	Invivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis Invivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis	[PMID: 32292567]
EMT6	IC₅₀	956 nM Compound: 3	In vivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis In vivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis	[PMID: 32292567]

Chemical Information

CAS No. 2376189-62-5
분자량 256.11
화학식 C₁₁H₂₁BN₂O₄
SMILES

OB(O)CCC[C@H]1[C@@]2([H])[C@@](CNC2)([H])C[C@@]1(N)C(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mitcheltree MJ, et al. Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. ACS Med Chem Lett. 2020 Mar 23;11(4):582-588. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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