ARG1-IN-1
ARG1-IN-1 (Compound 3) is an orally active arginase inhibitor with an IC50 value of 29 nM. ARG1-IN-1 can inhibit serum arginase activity and increase arginine levels in mouse tumor models. ARG1-IN-1 is applicable for tumor research.
For research use only. We do not sell to patients.
- CAS No.: 2376189-62-5
- Formula: C11H21BN2O4
- Molecular Weight:256.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EMT6 | IC50 |
956 nM
Compound: 3
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Invivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis
Invivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis
|
[PMID: 32292567] |
| EMT6 | IC50 |
956 nM
Compound: 3
|
In vivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis
In vivo inhibition of arginase in mouse EMT6 cells transplanted BALB/c mouse at 300 mg/kg, po bid by LCMS analysis
|
[PMID: 32292567] |
Chemical Information
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CAS No. 2376189-62-5
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Molecular Weight 256.11
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Formula C11H21BN2O4
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SMILES
OB(O)CCC[C@H]1[C@@]2([H])[C@@](CNC2)([H])C[C@@]1(N)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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