2 Results for "

BRAFV600E/WT

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "BRAFV600E/WT" in MCE Product Catalog:

Cat. No.: HY-155942
CAS No.: 708218-62-6
Target:  

p38 MAPK Raf

Research Areas:  

Cancer

B-Raf IN 19 (compound 31) is a BRAF inhibitor that inhibits BRAF(WT) and BRAF(V600E) (IC50: 0.57 μM and 0.28 μM, respectively). B-Raf IN 19 inhibits MAPK signaling in melanoma cells .
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Cat. No.: HY-107779R
CAS No.: 1392429-79-6
Target:  

Reference Standards Raf

Research Areas:  

Cancer

BI-882370 (Standard) is the analytical standard of BI-882370 (HY-107779). This product is intended for research and analytical applications. BI-882370 is a potent and selective RAF Kinase inhibitor that binds to the ATP binding site of the Kinase positioned in the DFG-out (inactive) conformation of the BRAF Kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF Kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family Kinases .
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