Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
BRPF1
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "BRPF1" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
OF-1, a chemical probe, is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC50 values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively [1] .
3
3 Cited Publications
Cat. No.: HY-18664
CAS No.: 900305-37-5
Target:
Research Areas:
PFI-4 (compound 11), a chemical probe, is a potent and highly selective BRPF1 Bromodomain (BRPF1B) inhibitor, with an IC50 of 172 nM. PFI-4 can be used to explore the functional mechanisms of the HBO1/BRPF1 complex and to study bone loss and osteolytic malignant bone lesions [1] .
2
2 Cited Publications
Target:
Research Areas:
GSK6853, a chemical probe, is a potent and selective inhibitor of the BRPF1 bromodomain. GSK6853 shows excellent BRPF1 potency (pKd = 9.5) and greater than 1600-fold selectivity over all other bromodomains [1].
1
1 Cited Publications
Synonyms: ASIS-P040 hydrochloride
Target:
Research Areas:
IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively [1].
1
1 Cited Publications
Cat. No.: HY-19537
CAS No.: 1883548-89-7
Target:
Research Areas:
NI-57, a chemical probe, is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.
1
1 Cited Publications
Target:
Research Areas:
GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively [1].
Cat. No.: HY-18665
CAS No.: 901245-65-6
Target:
Research Areas:
GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with an IC50 of ~ 80 nM [1].
Target:
Research Areas:
NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins [1].
Cat. No.: HY-143332
CAS No.: 3033288-68-2
Target:
Research Areas:
TRIM24/BRPF1-IN-2 (compound 20l) is a potent TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. TRIM24/BRPF1-IN-2 shows TRIM24/BRPF1 bromodomain binding affinity. TRIM24/BRPF1-IN-2 can be used for prostate cancer research [1].
Cat. No.: HY-151364
CAS No.: 2484255-65-2
HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both HDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1). HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC50 values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an Kd value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer [1].
Cat. No.: HY-102000
CAS No.: 1800477-30-8
Synonyms: ASIS-P040
Target:
Research Areas:
IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
Cat. No.: HY-122626
CAS No.: 1242907-48-7
Target:
Research Areas:
BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM [1].
Cat. No.: HY-RS01628
Target:
Research Areas:
BRPF1 Human Pre-designed siRNA Set A contains three designed siRNAs for BRPF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01629
Target:
Research Areas:
Brpf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Brpf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01630
Target:
Research Areas:
Brpf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Brpf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-151366
CAS No.: 2484255-85-6
Target:
Research Areas:
HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6 [1].
Cat. No.: HY-102000A
CAS No.: 1883598-69-3
Synonyms: ASIS-P040 TFA
Target:
Research Areas:
IACS-9571 (trifluoroacetate) is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kd of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
Cat. No.: HY-100729A
CAS No.: 2253733-09-2
Target:
Research Areas:
GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively [1].
Cat. No.: HY-P702191
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BRPF1; Bromodomain And PHD Finger Containing, 1, Isoform CRA_d; Bromodomain And PHD Finger Containing 1; Bromodomain And PHD Finger-Containing Protein 1; BR140; Bromodomain And PHD Finger Containing, 1; Peregrin; Protein Br140; Bromodomain-Containing Prot
Cat. No.: HY-P702192
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BRPF1; Bromodomain And PHD Finger Containing, 1, Isoform CRA_d; Bromodomain And PHD Finger Containing 1; Bromodomain And PHD Finger-Containing Protein 1; BR140; Bromodomain And PHD Finger Containing, 1; Peregrin; Protein Br140; Bromodomain-Containing Prot
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
