country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-102000A

Copy Link Print Information

IACS-9571 TFA

(Synonyms: ASIS-P040 TFA)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

IACS-9571 (trifluoroacetate) is a potent and selective inhibitor of TRIM24 and BRPF1, with IC₅₀ of 8 nM for TRIM24, and K_d of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

For research use only. We do not sell to patients.

CAS No.: 1883598-69-3
Formula: C₃₄H₄₃F₃N₄O₁₀S
Molecular Weight:756.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

IACS-9571 TFA Chemical Structure

CAS No.: 1883598-69-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IACS-9571 (trifluoroacetate) is a potent and selective inhibitor of TRIM24 and BRPF1, with IC₅₀ of 8 nM for TRIM24, and K_d of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

IC₅₀ & Target

IC50: 8 nM (TRIM24)^[1]
Kd: 31 nM (TRIM24), 14 nM (BRPF1)^[1]

All Epigenetic Reader Domain Isoforms :

In Vitro

IACS-9571 (trifluoroacetate) shows excellent cellular potency with EC₅₀ of 50 nM. IACS-9571 (trifluoroacetate) (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 (trifluoroacetate) is a selective dual TRIM24/BRPF1 inhibitor (K_d=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 (trifluoroacetate) does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4 (1, 2) relative to TRIM24^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1883598-69-3
Molecular Weight 756.79
Formula C₃₄H₄₃F₃N₄O₁₀S
SMILES

O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC(OCCC)=CC(OCCCCN(C)C)=C3)C=C(N4C)C(N(C)C4=O)=C2)=O.FC(F)(C(O)=O)F
Synonyms

ASIS-P040 TFA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

All

Sort by:

Journal Impact Factor

Proc Natl Acad Sci U S A

TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer. [Abstract]

2025 Aug 19;122(33):e2507571122. PMID: 40815626

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

IACS-9571 TFA

1 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

IACS-9571 TFA

Publications Citing Use of MedChemExpress (MCE) IACS-9571 TFA

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

IACS-9571 TFA Related Classifications

HY-102000A Related Classifications