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  3. IACS-9571 hydrochloride

IACS-9571 hydrochloride (Synonyms: ASIS-P040 hydrochloride)

Cat. No.: HY-102000B Purity: 99.28%
Handling Instructions

IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

For research use only. We do not sell to patients.

IACS-9571 hydrochloride Chemical Structure

IACS-9571 hydrochloride Chemical Structure

CAS No. : 2319611-93-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 374 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 374 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively[1].

IC50 & Target

IC50: 8 nM (TRIM24)[1]
Kd: 31 nM (TRIM24), 14 nM (BRPF1)[1]

In Vitro

IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

679.22

Formula

C32H43ClN4O8S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (184.03 mM; Need ultrasonic and warming)

H2O : 10 mg/mL (14.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4723 mL 7.3614 mL 14.7228 mL
5 mM 0.2945 mL 1.4723 mL 2.9446 mL
10 mM 0.1472 mL 0.7361 mL 1.4723 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
IACS-9571 hydrochloride
Cat. No.:
HY-102000B
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