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  3. IACS-9571

IACS-9571 (Synonyms: ASIS-P040)

Cat. No.: HY-102000
Handling Instructions

IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

For research use only. We do not sell to patients.

IACS-9571 Chemical Structure

IACS-9571 Chemical Structure

CAS No. : 1800477-30-8

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Description

IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

IC50 & Target

IC50: 8 nM (TRIM24)[1]
Kd: 31 nM (TRIM24), 14 nM (BRPF1)[1]

In Vitro

IACS-9571 shows excellent cellular potency with EC50 of 50 nM. IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (Kd = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

642.76

Formula

C₃₂H₄₂N₄O₈S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IACS-9571
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HY-102000
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