2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC Epigenetic Reader Domain
  4. HDAC8/BRPF1-IN-1

HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6.

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HDAC8/BRPF1-IN-1 Chemical Structure

HDAC8/BRPF1-IN-1 Chemical Structure

CAS No. : 2484255-85-6

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HDAC8/BRPF1-IN-1 Related Antibodies

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Description

HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1].

IC50 & Target[1]

hHDAC8

443 nM (IC50)

hBRPF1

67 nM (Ki)

In Vitro

HDAC8/BRPF1-IN-1 (Compound 23a) (4-100 μM; 24 h) shows antiproliferative activity against acute myeloid leukemia cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC8/BRPF1-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Acute myeloid leukemia cells THP-1 and HL60
Concentration: 4, 20 and 100 μM
Incubation Time: 24 h
Result: Inhibited THP-1 and HL60 cells growth.
Molecular Weight

417.44

Formula

C19H19N3O6S
CAS No.
SMILES

O=C(NO)C1=CC=C(OC)C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC8/BRPF1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8/BRPF1-IN-12484255-85-6HDACEpigenetic Reader DomainHistone deacetylasesBRPF1acute myeloid leukemiaHDAC8Inhibitorinhibitorinhibit

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