HDAC8/BRPF1-IN-1
HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6.
For research use only. We do not sell to patients.
- CAS No.: 2484255-85-6
- Formula: C19H19N3O6S
- Molecular Weight:417.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
hHDAC8 443 nM (IC50) |
hBRPF1 67 nM (Ki) |
HDAC8/BRPF1-IN-1 (Compound 23a) (4-100 μM; 24 h) shows antiproliferative activity against acute myeloid leukemia cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Acute myeloid leukemia cells THP-1 and HL60
-
Concentration:4, 20 and 100 μM
-
Incubation Time:24 h
-
Result:Inhibited THP-1 and HL60 cells growth.
Chemical Information
-
CAS No. 2484255-85-6
-
Molecular Weight 417.44
-
Formula C19H19N3O6S
-
SMILES
O=C(NO)C1=CC=C(OC)C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC8/BRPF1-IN-1 Related Classifications
HY-151366 Related Classifications
Powered by Bioz