919973-83-4
919973-83-4
Chemical Structure
OF-1
- CAS No.: 919973-83-4
- Formula:C17H18BrN3O4S
- Molecular Weight:440.31
IUPAC Name: 4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide
InChIKey: YUNQZQREIHWDQT-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O
Biological Activity: OF-1, a chemical probe, is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC50 values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
OF-1 | 98.93% | OF-1, a chemical probe, is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC50 values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.60
HY-122626BRPF1B/TRIM24-IN-1 -
Similarity Score 0.57
HY-111502Y06036 -
Similarity Score 0.54
HY-124585Y08060 -
Similarity Score 0.54
![5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one Chemical Structure](//file.medchemexpress.com/product_pic/hy-43367.gif)
HY-433675-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one -
Similarity Score 0.54
HY-19537NI-57 -
Similarity Score 0.53
HY-102000IACS-9571 -
Similarity Score 0.53
HY-102000BRIACS-9571 hydrochloride (Standard) -
Similarity Score 0.52
HY-18664PFI-4 -
Similarity Score 0.52
HY-151366HDAC8/BRPF1-IN-1 -
Explore the MedChemAI to find more analogs
![5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one Chemical Structure](http://file.medchemexpress.com/product_pic/hy-43367.gif)
References
- [1]. Julia C Meier, et al. Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630. [Content Brief]
- [2]. James Bennett, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7. [Content Brief]
