1. Epigenetics
  2. Epigenetic Reader Domain
  3. GSK6853

GSK6853 

Cat. No.: HY-100220 Purity: 99.31%
Handling Instructions

pKd: 9.5 (BRPF1)

GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain.

For research use only. We do not sell to patients.

GSK6853 Chemical Structure

GSK6853 Chemical Structure

CAS No. : 1910124-24-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 68 In-stock
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 75 In-stock
Estimated Time of Arrival: December 31
10 mg USD 135 In-stock
Estimated Time of Arrival: December 31
50 mg USD 420 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain. GSK6853 shows excellent BRPF1 potency (pKd=9.5) and greater than 1600-fold selectivity over all other bromodomains[1].

In Vivo

The ip route of administration would be suitable for dosing GSK6853 in potential PK/PD models[1].

Molecular Weight

409.48

Formula

C₂₂H₂₇N₅O₃

CAS No.

1910124-24-1

SMILES

C[[email protected]@H]1CNCCN1C2=C(NC(C3=CC=CC=C3OC)=O)C=C(C(N4C)=C2)N(C)C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 29 mg/mL (70.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4421 mL 12.2106 mL 24.4212 mL
5 mM 0.4884 mL 2.4421 mL 4.8842 mL
10 mM 0.2442 mL 1.2211 mL 2.4421 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.31%

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Keywords:

GSK6853GSK 6853GSK-6853Epigenetic Reader DomainInhibitorinhibitorinhibit

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GSK6853
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HY-100220
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