2. Epigenetics
  3. Epigenetic Reader Domain
  4. GSK6853

GSK6853 

Cat. No.: HY-100220 Purity: 99.40%
COA Handling Instructions

pKd: 9.5 (BRPF1)

GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain.

For research use only. We do not sell to patients.

GSK6853 Chemical Structure

GSK6853 Chemical Structure

CAS No. : 1910124-24-1

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 68 In-stock
Solution
10 mM * 1 mL in DMSO USD 68 In-stock
Solid
2 mg USD 50 In-stock
5 mg USD 75 In-stock
10 mg USD 135 In-stock
50 mg USD 420 In-stock
100 mg USD 650 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

GSK6853 Related Antibodies

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Description

GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain. GSK6853 shows excellent BRPF1 potency (pKd=9.5) and greater than 1600-fold selectivity over all other bromodomains[1].

In Vivo

The ip route of administration would be suitable for dosing GSK6853 in potential PK/PD models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

409.48

Appearance

Solid

Formula

C22H27N5O3
CAS No.
SMILES

C[C@@H]1CNCCN1C2=C(NC(C3=CC=CC=C3OC)=O)C=C(C(N4C)=C2)N(C)C4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (61.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4421 mL 12.2106 mL 24.4212 mL
5 mM 0.4884 mL 2.4421 mL 4.8842 mL
10 mM 0.2442 mL 1.2211 mL 2.4421 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.40%

COA (256 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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GSK6853 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GSK68531910124-24-1GSK 6853GSK-6853Epigenetic Reader DomainInhibitorinhibitorinhibit

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