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Results for "

Bronchospasm

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

2

Peptides

1

Natural
Products

5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1037
    Salbutamol
    Maximum Cited Publications
    7 Publications Verification

    Albuterol; AH-3365

    Adrenergic Receptor ERK Inflammation/Immunology Cancer
    Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .
    Salbutamol
  • HY-N0283
    Diacerein
    5+ Cited Publications

    Diacerhein; Diacetylrhein

    Interleukin Related Calcium Channel Inflammation/Immunology
    Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .
    Diacerein
  • HY-P0012
    Aviptadil
    2 Publications Verification

    Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)

    SARS-CoV Infection Inflammation/Immunology
    Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .
    Aviptadil
  • HY-B0976

    Th-1165; Phenoterol

    Adrenergic Receptor Inflammation/Immunology Endocrinology
    Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .
    Fenoterol
  • HY-B0976A

    Th-1165a; Phenoterol hydrobromide

    Adrenergic Receptor Inflammation/Immunology Endocrinology
    Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .
    Fenoterol hydrobromide
  • HY-B0436
    Salbutamol hemisulfate
    Maximum Cited Publications
    7 Publications Verification

    Albuterol hemisulfate; AH-3365 hemisulfate

    Adrenergic Receptor ERK Inflammation/Immunology Cancer
    Salbutamol (Albuterol) hemisulfate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol hemisulfate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol hemisulfate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .
    Salbutamol hemisulfate
  • HY-B0004

    Adenosine Receptor Phosphodiesterase (PDE) Reactive Oxygen Species (ROS) Inflammation/Immunology
    Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm .
    Doxofylline
  • HY-19393

    Phosphodiesterase (PDE) Cardiovascular Disease Inflammation/Immunology Cancer
    SCH 351591 is a highly selective, orally active PDE4 inhibitor, with IC50 values of 58 nM and 153 nM in humans and rats, respectively. SCH 351591 effectively inhibits pathological processes such as cytokine production, eosinophilia, airway hyperresponsiveness and bronchospasm. SCH 351591 also induces microvascular injury, activates mast cells and endothelial cells, and causes increases in serum histamine and various inflammatory factors, leading to early vascular damage. SCH 351591 has been widely used in studies related to asthma, chronic obstructive pulmonary disease and drug-induced vascular injury .
    SCH 351591
  • HY-100634

    (±)-4-hydroxy Propranolol hydrochloride

    Adrenergic Receptor Cardiovascular Disease
    4-Hydroxypropranolol hydrochloride is a non-cardiac selective β-adrenergic receptor antagonist and a metabolite produced after oral administration of Propranolol (HY-B0573B). 4-Hydroxypropranolol hydrochloride also acts as a membrane stabilizer and possesses intrinsic sympathomimetic inhibitory activity. 4-Hydroxypropranolol hydrochloride blocks β-adrenergic receptors to antagonize the effects of catecholamines, acts as a partial β-adrenergic receptor agonist, and induces membrane stabilization. 4-Hydroxypropranolol hydrochloride alters heart rate, left ventricular contractility, and atrioventricular conduction time. 4-Hydroxypropranolol hydrochloride can be used in research related to cardiovascular and cerebrovascular diseases .
    4-Hydroxypropranolol hydrochloride
  • HY-118545

    STAT Inflammation/Immunology Cancer
    Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma .
    Butamirate
  • HY-P0012A
    Aviptadil acetate
    2 Publications Verification

    Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)

    SARS-CoV Infection Inflammation/Immunology
    Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .
    Aviptadil acetate
  • HY-118545A

    STAT Inflammation/Immunology Cancer
    Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .
    Butamirate citrate
  • HY-B1037S

    Albuterol-d3; AH-3365-d3

    Isotope-Labeled Compounds ERK Adrenergic Receptor Inflammation/Immunology Cancer
    Salbutamol-d3 (Albuterol-d3) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .
    Salbutamol-d3
  • HY-B1037S2

    Albuterol-d9; AH-3365-d9

    Isotope-Labeled Compounds ERK Adrenergic Receptor Inflammation/Immunology Cancer
    Salbutamol-d9 (Albuterol-d9) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .
    Salbutamol-d9
  • HY-101445R

    Reference Standards Reactive Oxygen Species (ROS) Ferroptosis Apoptosis Cancer
    Butamirate (citrate) (Standard) is the analytical standard of Butamirate (citrate). This product is intended for research and analytical applications. Butamirate citrate is an orally active cough suppressant that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect .
    Trolox (Standard)
  • HY-B1037R

    Albuterol (Standard); AH-3365 (Standard)

    Reference Standards Adrenergic Receptor ERK Inflammation/Immunology Cancer
    Salbutamol (Standard) is the analytical standard of Salbutamol. This product is intended for research and analytical applications. Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol promotes tumorigenesis of gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol is used to study bronchospasms caused by asthma and chronic obstructive pulmonary disease (COPD) .
    Salbutamol (Standard)
  • HY-118545AR

    Reference Standards STAT Inflammation/Immunology Cancer
    Butamirate citrate (Standard) is the analytical standard of Butamirate citrate (HY-118545A). This product is intended for research and analytical applications. Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .
    Butamirate citrate (Standard)
  • HY-B0436R

    Albuterol hemisulfate (Standard); AH-3365 hemisulfate (Standard)

    Reference Standards Adrenergic Receptor ERK Inflammation/Immunology Cancer
    Salbutamol (Albuterol) hemisulfate (Standard) is the analytical standard of Salbutamol hemisulfate (HY-B0436). This product is intended for research and analytical applications. Salbutamol (Albuterol) hemisulfate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol hemisulfate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol hemisulfate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.
    Salbutamol hemisulfate (Standard)
  • HY-B1037S3

    Albuterol-d9 acetate; AH-3365-d9 acetate

    Isotope-Labeled Compounds ERK Adrenergic Receptor Inflammation/Immunology Cancer
    Salbutamol-d9 (Albuterol-d9) acetate is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .
    Salbutamol-d9 acetate
  • HY-101235

    Prostaglandin Receptor Cardiovascular Disease Inflammation/Immunology
    ICI 185282 is a potent, selective, orally active thromboxane A2 (TXA₂) receptor antagonist. ICI 185282 causes dose-dependent inhibition of U-46619 (HY-108566)-induced platelet aggregation ex-vivo in guinea-pig. ICI 185,282 inhibits bronchospasm induced by U-46619, PGD2 (HY-101988), PGF (HY-12956), arachidonic acid (HY-109590), LTD4 and PAF (HY-108635) in vivo. ICI 185282 can be used for bronchial asthma research .
    ICI 185282
  • HY-B0976AR

    Th-1165a (Standard); Phenoterol hydrobromide (Standard)

    Reference Standards Adrenergic Receptor Inflammation/Immunology Endocrinology
    Fenoterol (hydrobromide) (Standard) is the analytical standard of Fenoterol (hydrobromide). This product is intended for research and analytical applications. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .
    Fenoterol hydrobromide (Standard)
  • HY-120755

    Leukotriene Receptor Inflammation/Immunology
    LY290324 is a potent and orally active leukotriene D4 (LTD4) antagonist. LY290324 reduces LTC4, LTD4 and LTE4 (HY-113465)-induced bronchospasm. LY290324 has the potential for the research of antigen-induced bronchospasm .
    LY290324
  • HY-109006

    mAChR Neurological Disease
    Ilmetropium iodide is an anticholinergic agent. Ilmetropium iodide selectively blocks M-cholinergic receptors of bronchial muscle, reduces or prevents bronchoconstrictor response associated with both cholinergic stimulation, as well as the impact of the factors that provoke bronchospasm. Strength and selectivity of ilmetropium iodide action substantially exceeds Atropine sulfate (HY-B1205A) and Ipratropium bromide (HY-B0241) .
    Ilmetropium iodide
  • HY-B0004R

    Reference Standards Adenosine Receptor Phosphodiesterase (PDE) Reactive Oxygen Species (ROS) Inflammation/Immunology
    Doxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm .
    Doxofylline (Standard)
  • HY-118376

    Biochemical Assay Reagents Others
    Nestifylline is a biochemical reagent. Nestifylline can be used to study respiratory diseases such as bronchospasm .
    Nestifylline
  • HY-121185A

    Adrenergic Receptor Infection Neurological Disease Inflammation/Immunology Endocrinology
    Hexoprenaline sulfate is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline sulfate can dilate the bronchi. Hexoprenaline sulfate can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline sulfate exhibits anti-infection and anti-inflammmation effect. Hexoprenaline sulfate can increase placental weight and blood flow. Hexoprenaline sulfate can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds .
    Hexoprenaline sulfate
  • HY-164650

    Sch 37224

    Leukotriene Receptor Inflammation/Immunology
    Pirodomast (Sch 37224) is a leukotriene formation inhibitor. Pirodomast inhibits LTD4 andthromboxane B2 release by anaphylactic guinea pig lung with the IC50 values of 3.9 and 1.9 μM, respectively. Pirodomast can be used for study of asthma .
    Pirodomast
  • HY-116051A

    16,16-Dimethyl-PGF2β

    Prostaglandin Receptor Cardiovascular Disease
    16,16-Dimethylprostaglandin F2β (16,16-Dimethyl-PGF2β) is an analog of PGF2β (HY-12956B), which is an irratant, but prevents the aspecifically induced bronchospasm .
    16,16-Dimethylprostaglandin F2β
  • HY-B0976AS

    Isotope-Labeled Compounds Adrenergic Receptor Inflammation/Immunology Endocrinology
    Fenoterol-d6 (hydrobromide) (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .
    Fenoterol-d6 hydrobromide
  • HY-B1037B

    Albuterol adipate; AH-3365 adipate

    Adrenergic Receptor ERK Inflammation/Immunology Cancer
    Salbutamol (Albuterol) adipate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol adipate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol adipate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .
    Salbutamol adipate
  • HY-W707640

    Albuterol-d4; AH-3365-d4

    Isotope-Labeled Compounds ERK Adrenergic Receptor Cancer
    Salbutamol-d4 (Albuterol-d4; AH-3365-d4) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol promotes tumorigenesis of gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol is used to study bronchospasms caused by asthma and chronic obstructive pulmonary disease (COPD) .
    Salbutamol-d4
  • HY-117811

    L-680574

    Platelet-activating Factor Receptor (PAFR) Cardiovascular Disease
    (R,R)-MK 287 (L-680574) is a tetrahydrofuran derivative that potently inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. (R,R)-MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50=56 nM) and elastase release from PMNs (ED50=4.4 nM). (R,R)-MK 287 inhibits PAF-induced lethality in mice (ED50=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED50=0.18 mg/kg) .
    (R,R)-MK 287
  • HY-118392

    Xanthaline

    Histamine Receptor Inflammation/Immunology
    Papaveraldine (Xanthaline) is a benzylisoquinoline alkaloid that shows antispasmodic and protective activity against histamine-induced bronchospasm in rats. Papaveraldine is an active ingredient of a hair tonic preparation that promotes melanin formation for grey hair .
    Papaveraldine
  • HY-129546

    Endogenous Metabolite Inflammation/Immunology
    Eprozinol hydrochloride is a compound with antibronchoconstrictor activity. Eprozinol hydrochloride can be used in the study of bronchospasm .
    Eprozinol hydrochloride
  • HY-W721659

    SQ 13,847

    Drug Intermediate Others
    Pirquinozol (SQ 13,847) is an orally active anti-allergy agent. Pirquinozol is converted to the oxidation metabolite SQ 12,903, which can exert the maximum activity. Pirquinozol inhibits bronchospasm in rats .
    Pirquinozol
  • HY-W988549

    MDL-257

    Phosphodiesterase (PDE) Inflammation/Immunology
    Zindotrine (MDL-257) is an orally active bronchodilator. Zindotrine is a cGMP phosphodiesterase (PDE) inhibitor. Zindotrine can counteract bronchospasm caused by histamine. Zindotrine can be used to study reversible airflow obstruction, such as asthma .
    Zindotrine
  • HY-B0976R

    Th-1165 (Standard); Phenoterol (Standard)

    Adrenergic Receptor Reference Standards Inflammation/Immunology Endocrinology
    Fenoterol (Standard) is the analytical standard of Fenoterol. This product is intended for research and analytical applications. Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .
    Fenoterol (Standard)
  • HY-180363

    Lipoxygenase Leukotriene Receptor Inflammation/Immunology
    E 6080 is an orally active and selective 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 0.2 μM in rat basophilic leukemia cell. E 6080 shows potent inhibitory effects on the release of leukotrienes. E 6080 inhibits the bronchospasm induced by antigen (ovalbumin) inhalation in sensitized conscious guinea pigs. E 6080 can be used for the study of asthma .
    E 6080
  • HY-181770

    Phosphodiesterase (PDE) Bacterial Infection Inflammation/Immunology
    PDE4B-IN-7 is a PDE-4B inhibitor with an IC50 of 160 nM. PDE4B-IN-7 can form a firm and stable binding with the active site of PDE-4B. PDE4B-IN-7 inhibits acetylcholine-induced bronchospasm in guinea pigs. PDE4B-IN-7 exerts activity against susceptible Gram-positive and Gram-negative bacterial strains. PDE4B-IN-7 can be used for the researches of asthma and bacterial agent .
    PDE4B-IN-7
  • HY-182557

    Lipoxygenase Cardiovascular Disease Inflammation/Immunology
    KC-11404 is an orally active antihistamine and 5-lipoxygenase inhibitor, with an IC50 of 0.9 μM against guinea pig 5-lipoxygenase. KC-11404 inhibits histamine-induced contraction of isolated guinea pig ileum with an IC50 of 0.26 μM. KC-11404 inhibits PAF-induced rabbit platelet aggregation with an IC50 of 2.0 μM. It inhibits the histamine phase of antigen-induced bronchoconstriction and PAF-induced bronchoconstriction in guinea pigs. KC-11404 can be used for the research of asthma .
    KC-11404

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