40077-57-4
Chemical Structure
Aviptadil
Synonym(s): Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)
- CAS No.: 40077-57-4
- Formula:C147H238N44O42S
- Molecular Weight:3325.80
SMILES: O=C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC4=CNC=N4)N
Biological Activity: Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aviptadil | 99.95% | Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al. | ||||||||||||||||||||
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Similarity Score 0.99
HY-P0012AAviptadil acetate -
Similarity Score 0.94
HY-P1015VIP(Guinea pig) -
Similarity Score 0.90
HY-P4014HSDAVFTDNYTRLRRQLAVRRYLNSILN-NH2 -
Similarity Score 0.88
HY-P0176PACAP (1-27), human, ovine, rat -
Similarity Score 0.87
HY-P4776Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) -
Similarity Score 0.87
![[K15,R16,L27]VIP(1-7)/GRF(8-27) Chemical Structure](//file.medchemexpress.com/product_pic/hy-p4195.gif)
HY-P4195[K15,R16,L27]VIP(1-7)/GRF(8-27) -
Similarity Score 0.86
HY-P1160Bay 55-9837 -
Similarity Score 0.86
HY-P5111Myristoyl-(Lys12,27,28)-VIP-Gly-Gly-Thr free acid -
Similarity Score 0.86
![[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Chemical Structure](//file.medchemexpress.com/product_pic/hy-p0211.gif)
HY-P0211[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) -
Explore the MedChemAI to find more analogs
![[K15,R16,L27]VIP(1-7)/GRF(8-27) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-p4195.gif)
![[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-p0211.gif)
References
- [1]. Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV)
- [2]. Jian Hu, et al. Novel Targets of Drug Treatment for Pulmonary Hypertension. Am J Cardiovasc Drugs [Content Brief]
- [3]. Hamidi SA, et al. VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension. Respir Res. 2011;12(1):141. Published 2011 Oct 26. [Content Brief]
- [4]. Hamidi SA, et al. VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension. Respir Res. 2011;12(1):141. Published 2011 Oct 26.
- [5]. Nagahiro I, et al. Vasoactive intestinal peptide ameliorates reperfusion injury in rat lung transplantation. J Heart Lung Transplant. 1998;17(6):617-621. [Content Brief]
