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Results for "

C5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (40) ADC Linker (8) Adenosine Receptor (1) Adrenergic Receptor (14) Akt (5) Amino Acid Derivatives (5) AMPK (1) Amylases (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (4) Antifolate (2) Apoptosis (36) Arginase (4) Atg7 (1) Atg8/LC3 (1) ATP Synthase (1) Autophagy (20) Bacterial (18) Bcl-2 Family (2) Beta-lactamase (2) Biochemical Assay Reagents (14) c-Fms (1) c-Kit (1) c-Myc (1) Caspase (1) CCR (1) CD3 (2) CDK (2) Cholinesterase (ChE) (1) Collagen (1) Complement System (58) CXCR (3) Cytochrome P450 (4) Dipeptidyl Peptidase (1) DNA Methyltransferase (2) DNA/RNA Synthesis (17) Dopamine Receptor (11) Drug Derivative (5) Drug Isomer (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (6) E3 Ligase Ligand-Linker Conjugates (47) EGFR (2) Endogenous Metabolite (82) Enterovirus (1) Estrogen Receptor/ERR (2) Ferroptosis (8) FGFR (1) FLT3 (1) Fluorescent Dye (7) Formyl Peptide Receptor (FPR) (1) Fungal (3) GCGR (2) GLP Receptor (1) HCV (2) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (2) Histone Acetyltransferase (1) Histone Demethylase (2) HIV (1) HSP (1) IFNAR (1) iGluR (5) Isotope-Labeled Compounds (143) Keap1-Nrf2 (1) Ligands for E3 Ligase (6) mAChR (6) mGluR (3) MHC (1) MicroRNA (116) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) Mitophagy (5) MOFs (2) Molecular Glues (4) mTOR (1) NAMPT (1) NF-κB (3) NO Synthase (2) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (5) Orthopoxvirus (1) p38 MAPK (1) PAK (1) Parasite (3) PCSK9 (1) PDGFR (1) Phosphodiesterase (PDE) (3) Phosphoramidites (3) Phytohormone (1) PPAR (2) Progesterone Receptor (1) Prostaglandin Receptor (2) PROTAC Linkers (20) PROTACs (4) Reactive Oxygen Species (ROS) (6) Reference Standards (11) RSV (1) SARS-CoV (5) SHP2 (1) Sigma Receptor (1) Small Interfering RNA (siRNA) (8) Src (1) STAT (1) Target Protein Ligand-Linker Conjugates (1) TGF-β Receptor (1) Thymidylate Synthase (1) TNF Receptor (1) Toll-like Receptor (TLR) (2) Tyrosinase (1) VD/VDR (2) VEGFR (1) Wee1 (1)
By Research Areas:	Cancer (249) Cardiovascular Disease (23) Endocrinology (11) Infection (30) Inflammation/Immunology (69) Metabolic Disease (41) Neurological Disease (64)
Click Chemistry:	ADC Synthesis (2) DBCO (1) PROTAC Synthesis (1) Azide (11) Alkynes (2)
Oligonucleotides:	miRNA mimics (29) miRNA antagomirs (29) Nucleotide Analogs (1) Rat Pre-designed siRNA Sets (2) miRNA inhibitors (29) siRNA drugs (2) Other Phosphoramidite (1) siRNAs (9) Fluorescent Lipids (1) miRNA agomirs (29) MicroRNAs (116) Aptamers (4) Cytosine (2) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (4) Phosphoramidites (3)

542

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

159

Isotope-Labeled Compounds

Antibodies

Click Chemistry

134

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9914

Eculizumab 4 Publications Verification Anti-Human C5, Humanized Antibody; h5G1.1	Complement System	Cardiovascular Disease Neurological Disease
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .

HY-128729

DNA2 inhibitor C5 5+ Cited Publications	DNA/RNA Synthesis	Cancer
DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC₅₀ of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research .

HY-P99965

Crovalimab SKY59; RO7112689; RG-6107	Complement System	Cardiovascular Disease Metabolic Disease
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .

HY-126523

N3-C5-NHS ester	ADC Linker	Cancer
N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C5-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132248

C5 Lenalidomide Lenalidomide 5'-amine	Drug Derivative TNF Receptor	Inflammation/Immunology
C5 Lenalidomide is a 5-amino-substituted Thalidomide (HY-14658) analog. C5 Lenalidomide inhibits LPS (HY-D1056)-stimulated TNF-α production .

HY-D1610

BODIPY FL C5	Fluorescent Dye	Others
BODIPY FL C₅ is a green fluorescent fatty acid. BODIPY FL C₅ can be used as a precursor for the synthesis of various fluorescent phospholipids. BODIPY FL C₅ is relatively insensitive to the environment and fluoresces in both water-soluble and lipid environments .

HY-157080

Dibromomaleimide-C5-COOH DBM-C5-COOH	ADC Linker	Cancer
Dibromomaleimide-C5-COOH (DBM-C5-COOH) is a bifunctional dibromomaleimide (DBM) linker. Dibromomaleimide-C5-COOH can be used to connect MMAF and to synthesize ADC .

HY-P99322

Tesidolumab LFG316; Anti-Human C5 Recombinant Antibody	Complement System	Inflammation/Immunology
Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex .

HY-W004710

NH2-C5-NH-Boc PROTAC Linker 23	PROTAC Linkers	Cancer
NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs .

HY-145720

Cemdisiran ALN-CC5	Complement System Small Interfering RNA (siRNA)	Metabolic Disease
Cemdisiran (ALN-CC5) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .

HY-148457

Avacincaptad pegol Izervay	Complement System	Infection Neurological Disease Inflammation/Immunology
Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory *C5a* and *C5b, which forms the membrane attack complex (C5b-9),* thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA .

HY-151667

Biotin-C5-Azide DecarboxyBiotin-N3	Fluorescent Dye	Others
Biotin-C5-Azide (DecarboxyBiotin-N3) is a biotin reagent and can be used to prepare biotinylated conjugates . Biotin-C5-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128342

Complement C5-IN-1 1 Publications Verification	Complement System	Inflammation/Immunology
Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC₅₀ of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-141840

GLP-1R modulator C5	GCGR	Metabolic Disease
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC₅₀ 1.59 ± 0.53 μM).

HY-P99638

Gefurulimab ALXN-1720	Complement System	Inflammation/Immunology
Gefurulimab (ALXN-1720) is a high-affinity antibody inhibitor targeting complement protein C5, which can specifically bind to C5 and inhibit its cleavage into C5a and C5b. Gefurulimab can block the activation of the terminal complement pathway and reduce inflammatory damage. Gefurulimab can effectively reduce the formation of membrane attack complex (MAC) and has good pharmacokinetic properties. Gefurulimab can be used to study kidney and autoimmune diseases related to abnormal activation of the complement system, such as IgA nephropathy, lupus nephritis, and myasthenia gravis .

HY-122725B

Lenalidomide-C5-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 hydrochloride can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2 .

HY-P5506

C5a Receptor agonist, W5Cha	Complement System	Others
C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement C5a receptor (C5aR) agonist (EC₅₀=0.2 μM), a hexapeptide derived from the C-terminus of *C5a* with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the C5a receptor through its C-terminal arginine, thereby activating the receptor .

HY-164088

DBM-C5-VC-PAB-MMAE	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
DBM-C5-VC-PAB-MMAE (Compound 3a) is a Drug-Linker conjugate for ADC. DBM-C5-VC-PAB-MMAE is composed of a linker C5-VC-PAB with a maleimide group DBM and an ADC toxin MMAE (HY-15162) .

HY-160241

Lenalidomide-C5-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-acid is the Lenalidomide-based E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Lenalidomide-C5-acid can be used to synthesize PROTACs .

HY-D1613

BODIPY FL C5-HPC	Fluorescent Dye	Others
BODIPY FL C5-HPC is a lipophilic green fluorescent dye (Ex/Em: 500/510 nm) .

HY-122725

Lenalidomide-C5-NH2	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2 .

HY-136187A

(S,R,S)-AHPC-C5-NH2 dihydrochloride VH032-C5-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .

HY-135915

Biotin-C5-NHS Ester	PROTAC Linkers	Cancer
Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-136055

(S,R,S)-AHPC-C5-COOH VH032-C5-COOH	E3 Ligase Ligand-Linker Conjugates HIF/HIF Prolyl-Hydroxylase	Cancer
(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a K_d of 185 nM, has the potential for the study of anemia and ischemic diseases .

HY-130849

(S,R,S)-AHPC-Me-C5-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604) .

HY-P10639

C5aR2 agonist P32	Complement System	Inflammation/Immunology
C5aR2 agonist P32 (Ac-RHYPYWR-OH) is a *C5aR2*-selective agonist. C5aR2 agonist P32 has been shown to elicit multiple immunomodulatory activities, both by down-regulating the C5aR1-mediated cell signalling, and acting in a C5aR1-independent fashion, in vitro and in vivo .

HY-137905

Pomalidomide-amido-C5-PEG2-C6-chlorine	Drug Derivative	Cancer
Pomalidomide-amido-C5-PEG2-C6-chlorine is a derivant of Pomalidomide (HY-10984) .

HY-128729R

DNA2 inhibitor C5 (Standard)	Reference Standards DNA/RNA Synthesis	Cancer
DNA2 inhibitor C5 (Standard) is the analytical standard of DNA2 inhibitor C5 (HY-128729). This product is intended for research and analytical applications. DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC₅₀ of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research.

HY-129608

Lenalidomide-acetylene-C5-COOH Cereblon ligand-linker Conjugate	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC . Lenalidomide-acetylene-C5-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141143

MC(C5)-Val-Cit	ADC Linker	Cancer
MC(C5)-Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-RS01749

C5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C5 Human Pre-designed siRNA Set A contains three designed siRNAs for C5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C5 Human Pre-designed siRNA Set A C5 Human Pre-designed siRNA Set A

HY-135916

Biotin-C5-amino-C5-amino	PROTAC Linkers	Cancer
Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-D1592

BODIPY TMR C5-maleimide	Fluorescent Dye	Others
BODIPY TMR C5-maleimide is a fluorescent dye. BODIPY TMR C5-maleimide is a high quantum yield fluorophore which can be coupled with peptides .

HY-175260

ZN-c5	Estrogen Receptor/ERR	Cancer
ZN-c5 is a selective and orally active estrogen receptor degrader. ZN-c5 exhibits high potency in the cellular assay (MCF-7, IC₅₀ = 0.3 nM) and binds with high affinity to ERα and ERβ (IC₅₀ = 0.4 nM and 0.8 nM, respectively). ZN-c5 inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 can be used for the study of breast cancer .

HY-161939

7030B-C5	PCSK9	Cardiovascular Disease
7030B-C5 is a PCSK9 inhibitor (IC₅₀=1.61 μM). 7030B-C5 can significantly reduce plasma cholesterol and triglyceride (TG) levels in vivo and slow the progression of atherosclerosis. 7030B-C5 can be used in the study of cardiovascular diseases .

HY-139996

Pomalidomide-C5-Dovitinib	PROTACs Apoptosis FLT3 c-Kit FGFR VEGFR PDGFR c-Fms	Cancer
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD ⁺ acute myeloid leukemia .

HY-164829

Mal-C5-Gly-Gly-Phe-MMAE	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
Mal-C5-Gly-Gly-Phe-MMAE (Compound S5) is a drug-linker conjugate for ADC. Mal-C5-Gly-Gly-Phe-MMAE consists of MMAE (HY-15162) and a linker. Mal-C5-Gly-Gly-Phe-MMAE can be used for synthesis of ADCs and for cancer research .

HY-132856

Lenalidomide-C5-amido-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC .

HY-W369104

Boc-MeN-C5-OH	PROTAC Linkers	Cancer
Boc-MeN-C5-OH is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W688682

(S,R,S)-AHPC-C5-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-C5-NH2 hydrochloride can be used to synthesize PROTAC.

HY-130530

AP-C5	Biochemical Assay Reagents	Metabolic Disease
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149562

Thalidomide-5-O-C5-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-5-O-C5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

HY-163788

C5-CONH-C2-N-CH3	PROTAC Linkers	Others
C5-CONH-C2-N-CH3 is a PROTAC linker that can be used in the synthesis of PROTACs .

HY-D1611

BODIPY FL-C5 NHS Ester	Fluorescent Dye	Others
BODIPY FL-C5 NHS Ester is a green-fluorescent dye that is reactive with primary amines on biomolecules such as peptides, proteins, modified nucleotides and biopolymers .

HY-131889

Thalidomide-O-C5-acid	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-C5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-139336

Pomalidomide-C5-azide	E3 Ligase Ligand-Linker Conjugates	Others
Pomalidomide-C5-azide is an E3 ubiquitin ligase cereblon (CRBN) ligand-Linker conjugate. The azide group can undergo a click chemical reaction .

HY-W998298

(S,R,S)-AHPC-C5-PEG3-C3	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C5-PEG3-C3 is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-C5-PEG3-C3 can be used to synthesize PROTAC.

HY-W586819

C5 Lenalidomide-CH3	Ligands for E3 Ligase	Cancer
C5 Lenalidomide-CH3 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. C5 Lenalidomide-CH3 can be linked to a target protein ligand via a linker to form a PROTAC.

HY-W949165

C5 Lenalidomide-6-fluoro	Ligands for E3 Ligase	Cancer
C5 Lenalidomide-6-fluoro is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. C5 Lenalidomide-6-fluoro can be linked to a target protein ligand via a linker to form a PROTAC.

HY-203808

5'-Carboxy-modifier C5	Phosphoramidites
5'-Carboxy-modifier C5 is a phosphoramidite that can be used in the synthesis of oligonucleotides.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W008820

Glutaric acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	MOFs Endogenous Metabolite
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W008820R

Glutaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I . In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .

HY-N3406

Lansiumarin C (+)-Lansiumarin C; 5-Demethoxymelicotriphyllin C	Clausena lansium (Lour.) Skeels Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Others
Lansiumarin C, a lansiumarin, can be isolated from the branches of Clausena lansium (Rutaceae) .

HY-117872

Sartorypyrone A 20-O-Acetylsartorypyrone D	Microorganisms Terpenoids Diterpenoids Source Classification	Fungal
Sartorypyrone A (20-O-Acetylsartorypyrone D) is a monocyclic terpenoid isolated from the soil fungus Neosartorya fischeri. Sartorypyrone A exhibits in vitro growth inhibitory activity against MCF-7, NCI-H460, and A375-C5 cell lines, and has potential anticancer properties.

HY-138098

Sartorypyrone B	Triterpenes Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI₅₀s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .

HY-N12728

Heteroclitin G	Kadsura heteroclita (Roxb.) Craib Lignans Phenylpropanoids Plants Schisandraceae Source Classification	Others
Heteroclitin G is a lignan which can be extracted from Dian-Jixueteng. Heteroclitin G (2.0 mg/kg, i.v.) exerts an C_5min of 665.97 ± 29.89 ng/mL and T_1/2z of 5.04 ± 1.84 h .

HY-N9418R

Gibberellin A5 (Standard)	Rosaceae Plants Rosa canina Gremli ex Christ Source Classification	Phytohormone Reference Standards
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-N13081

3-Oxo-cinobufagin	Microorganisms Steroids Source Classification	Others
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

Cat. No.	Product Name	Chemical Structure

HY-14608S5

L-Glutamic acid-13C5 1 Publications Verification
L-Glutamic acid- ¹³C₅ is the ¹³C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-W013636S

2-Ketoglutaric acid-13C5

2-Ketoglutaric acid- ¹³C₅ (Alpha-Ketoglutaric acid- ¹³C₅) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-N0326S5

L-Methionine-13C5 1 Publications Verification
L-Methionine- ¹³C₅ is the ¹³C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

HY-Y0252S

L-Proline-13C5
L-Proline- ¹³C₅ is the ¹³C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

HY-B0445S

NAD+-13C5 ammonium
NAD+-13C5 (ammonium) is the ¹³C labled NAD+ (HY-B0445), with an ammonium .

HY-14608S3

L-Glutamic acid-13C5,15N
L-Glutamic acid- ¹³C₅, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-N0092S2

Inosine-13C5 2 Publications Verification
Inosine- ¹³C₅ is the ¹³C₅ labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-N0717S6

L-Valine-13C5

L-Valine- ¹³C₅ ((S)-Valine- ¹³C₅) is the ¹³C-labeled L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase .

HY-Y0520S

Itaconic acid-13C5
Itaconic acid- ¹³C₅ is the ¹³C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors .

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-Y0252S4

L-Proline-13C5,15N
L-Proline- ¹³C₅,1- ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

HY-B1449S10

Uridine-13C5 1 Publications Verification
Uridine- ¹³C₅ (β-Uridine- ¹³C₅) is a ¹³C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.

HY-W040055S

Neopterin-13C5
Neopterin- ¹³C₅ (D-(+)-Neopterin- ¹³C₅; D-erythro-Neopterin- ¹³C₅) is the deuterium labeled Neopterin (HY-W040055) . Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation .

HY-W017018S2

L-Ornithine-1,2,3,4,5-13C5 hydrochloride
L-Ornithine-1,2,3,4,5- ¹³C₅ (hydrochloride) is the ¹³C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-B1654S

Flavin adenine dinucleotide-13C5 ammonium
Flavin adenine dinucleotide- ¹³C5 (FAD- ¹³C5) ammonium is ¹³C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

HY-W013780S1

Fmoc-Pro-OH-13C5,15N
Fmoc-Pro-OH- ¹³C₅, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Pro-OH (HY-W013780). Fmoc-Pro-OH is a proline derivative .

HY-14879S2

Avibactam sodium salt-13C5
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-W654041

Adenosine monophosphate-13C5
Adenosine monophosphate- ¹³C₅ (AMP- ¹³C₅) is ¹³C labeled Adenosine monophosphate. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .

HY-W018772S15

D-Ribose(mixture of isomers)-13C5

D-Ribose(mixture of isomers)- ¹³C₅ isomers)- ¹³C₅ is the ¹³C labeled D-Ribose(mixture of isomers) . D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-W779017

Thymidine-13C5
Thymidine- ¹³C₅ (DThyd- ¹³C₅; NSC 21548- ¹³C₅) is ¹³C-labeled Thymidine (HY-N1150) .

HY-N0326S6

L-Methionine-13C5,15N
L-Methionine- ¹³C₅, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

HY-N0322S3

Cholesterol-13C5

Cholesterol- ¹³C₅ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-W006057AS16

Sodium 3-methyl-2-oxobutanoate-13C5
Sodium 3-methyl-2-oxobutanoate- ¹³C₅ is the ¹³C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .

HY-B0152S3

Adenine-13C5

Adenine- ¹³C₅ (6-Aminopurine- ¹³C₅; Vitamin B4- ¹³C₅) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-16637S4

Folic acid-13C5,15N
Folic acid- ¹⁵N, ¹³C₅ is the ¹³C₅ and ¹⁵N labeled Folic acid (HY-16637) .

HY-14608S4

L-Glutamic acid-13C5,15N,d5
L-Glutamic acid- ¹³C₅, ¹⁵N,d₅ is the deuterium, ¹³C-, and 15-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-W008820S1

Glutaric acid-d4
Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W010184S

4,6-Dioxoheptanoic acid-13C5
4,6-Dioxoheptanoic acid- ¹³C₅ is the ¹³C labeled 4,6-Dioxoheptanoic acid . 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis .

HY-W013081S

Fmoc-Gln(Trt)-OH-13C5,15N2
Fmoc-Gln(Trt)-OH- ¹³C₅, ¹⁵N₂ is the ¹³C-labeled and ¹⁵N-labeled Fmoc-Gln(Trt)-OH (HY-W013081). Fmoc-Gln(Trt)-OH is a glutamine derivative containing amine protecting group Fmoc. Fmoc-Gln(Trt)-OH can be used in solid-phase peptide synthesis .

HY-P1033S1

[Pyr1]-Apelin-13, Pro(13C5,15N) TFA
[Pyr1]-Apelin-13, Pro( ¹³C5, ¹⁵N) (TFA) is the ¹³C and ¹⁵N labeled isotope of [Pyr1]-Apelin-13(HY-P1033).[Pyr1]-Apelin-13 is a potent and selective endogenous apelin receptor agonist .

HY-14781S2

Levomefolic acid-13C5
Levomefolic acid- ¹³C₅ is the ¹³C labeled Levomefolic acid . Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .

HY-N0210S4

D-Galactose-13C-5
D-Galactose- ¹³C-5 is the ¹³C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .

HY-N0379S10

D-Mannose-13C-5
D-Mannose- ¹³C-5 is the ¹³C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .

HY-W400722

Sodium 3-methyl-2-oxobutanoate-13C5,d1
Sodium 3-methyl-2-oxobutanoate- ¹³C₅,d₁ is the deuterium and ¹³C labeled Sodium 3-methyl-2-oxobutanoate .

HY-50719S1

2-Acetyl-1-pyrroline-13C5
2-Acetyl-1-pyrroline- ¹³C₅ is ¹³C labeled 2-Acetyl-1-pyrroline.

HY-76082S1

L-Pyroglutamic acid-13C5

L-Pyroglutamic acid- ¹³C₅ is the ¹³C labeled L-Pyroglutamic acid (HY-76082) . L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid can be used as a biomarker for systemic lupus erythematosus (SLE) .

HY-W008371S1

Fmoc-Met-OH-13C5,15N
Fmoc-Met-OH- ¹³C₅, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Met-OH (HY-W008371). Fmoc-Met-OH is a Methionine (HY-13694) derivative .

HY-W768333

D-Ribofuranose-13C5
D-Ribofuranose- ¹³C₅ (D-Ribose- ¹³C₅) is the ¹³C-labeled D-Ribofuranose (HY-113375). D-Ribofuranose (D-Ribose) is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Ribose 5 Phosphate Isomerase Deficiency and Medium Chain Acyl Co A Dehydrogenase Deficiency .

HY-B0434S

Ribavirin-13C5
Ribavirin- ¹³C₅ is the ¹³C-labeled Ribavirin. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.

HY-W768324

Ribitol-13C5
Ribitol- ¹³C₅ (Adonitol- ¹³C₅) is the ¹³C-labeled Ribitol (HY-100582). Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol.

HY-W768207

Cytidine-1',2',3',4',5'-13C5
Cytidine-1',2',3',4',5'- ¹³C₅ is the ¹³C-labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-113266S

Valerylcarnitine-d9
Valerylcarnitine-d9 (C5:0 L-carnitine-d9) is the deuterium labeled Valerylcarnitine (HY-113266). Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines .

HY-W767865

Cyclic GMP sodium-13C5

Cyclic GMP sodium- ¹³C₅ is the ¹³C-labeled Cyclic GMP sodium (HY-113469A). Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .

HY-W753201

5'-Methylthioadenosine-13C

5'-Methylthioadenosine- ¹³C (5'-(Methylthio)-5'-deoxyadenosine- ¹³C) is the ¹³C-labeled 5'-Methylthioadenosine (HY-16938). 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .

HY-W769319

Inosinic acid-13C5
Inosinic acid- ¹³C₅ (5'-IMP- ¹³C₅) is the ¹³C-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

HY-W814363

Octadec-9-enoic acid-13C5
Octadec-9-enoic acid-13C5 is a deuterated labeled Octadec-9-enoic acid-13C5 .

HY-W010256S3

D-Xylulose-13C5
D-Xylulose-13C5 is ¹³C labeled D-Xylulose. D-xylulose is the precursor of arabinitol .

HY-W769288

Pemetrexed disodium-13C5
Pemetrexed disodium- ¹³C₅ (LY231514 disodium- ¹³C₅) is the ¹³C-labeled Pemetrexed disodium (HY-10820A). Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .

HY-W779015

5-Methyluridine-13C5
5-Methyluridine- ¹³C₅ is ¹³C labeled 5-Methyluridine .

HY-W768302

D-Lyxose-13C5
D-Lyxose- ¹³C₅ is the ¹³C-labeled D-Lyxose. D-Lyxose is an?endogenous metabolite.

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