2891606-02-1
Chemical Structure
BM213
- CAS. Nr.: 2891606-02-1
- Formula:C43H70N12O10
- Molecular Weight:915.09
IUPAC Name: acetyl-L-phenylalanyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-alanyl-D-alanyl-L-arginine
InChIKey: QDSKFYCCEHFZAH-XVSJJFNZSA-N
SMILES: OC([C@@H](NC([C@@H](C)NC([C@H](C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H]1CCCN1C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C)=O)=O)CCCCN[H])=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O
Biological Activity: BM213 is a selective C5aR agonist, with an EC50 of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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BM213 | 99.62% | BM213 is a selective C5aR agonist, with an EC50 of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury. | ||||||||||||||||||||
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