2365402-67-9
Chemical Structure
Complement C5-IN-1
- CAS No.: 2365402-67-9
- Formula:C24H32N2O6
- Molecular Weight:444.52
IUPAC Name: (S)-5-methoxy-2-(3-(1-(2-methoxyphenyl)ethyl)ureido)-4-((4-methylpentyl)oxy)benzoic acid
InChIKey: UFAFCKVYKJIJTR-INIZCTEOSA-N
SMILES: COC1=C(OCCCC(C)C)C=C(NC(N[C@H](C2=C(OC)C=CC=C2)C)=O)C(C(O)=O)=C1
Biological Activity: Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Complement C5-IN-1 | 99.13% | Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). | ||||||||||||||||||||
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Keywords
