1254036-23-1
Chemical Structure
JPE-1375
- CAS No.: 1254036-23-1
- Formula:C49H63FN10O9
- Molecular Weight:955.08
IUPAC Name: (S)-N-((S)-1-(((S)-5-amino-1-((S)-2-(((S)-1-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-3-(4-fluorophenyl)-1-oxopropan-2-yl)amino)-5-methyl-1-oxohexan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2,6-dioxohexahydropyrimidine-4-carboxamide
InChIKey: HXKFHHNEFCZKPG-OAKHNGAUSA-N
SMILES: O=C([C@@H]1CC(NC(N1)=O)=O)N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCN)C(N3[C@@H](CCC3)C(N[C@@H](CCC(C)C)C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)CC5=CC=C(C=C5)F)=O)=O)=O)=O
Biological Activity: JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 μM) and reduces TNF levels (EC50=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases[1].
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JPE-1375 | 99.96% | JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 μM) and reduces TNF levels (EC50=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases. | ||||||||||||||||||||
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Keywords
