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Results for "

C5a receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (16) Leukotriene Receptor (1) NF-κB (1) Reactive Oxygen Species (ROS) (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (15)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138161

JR14a 5+ Cited Publications	Complement System	Inflammation/Immunology
JR14a is a potent thiophene antagonist of human complement C3a receptor. JR14a shows selectivity for the human C3a receptor over C5a receptor. JR14a can suppress C3aR-mediated inflammation .

HY-106178

PMX-53 5+ Cited Publications 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active *complement C5a* receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1** and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-110136

PMX 205 10+ Cited Publications	Complement System	Inflammation/Immunology
PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.

HY-P5506

C5a Receptor agonist, W5Cha	Complement System	Others
C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement **C5a receptor (C5aR) agonist (EC₅₀=0.2 μM), a hexapeptide derived from the C-terminus of C5a** with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the **C5a receptor** through its C-terminal arginine, thereby activating the receptor .

HY-P99450

Avdoralimab IPH 5401; Anti-C5aR1 mAb	Complement System	Inflammation/Immunology Cancer
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the *complement C5a* receptor 1 (C5aR1)** that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research .

HY-16992A

W-54011 5+ Cited Publications	Complement System Reactive Oxygen Species (ROS)	Inflammation/Immunology
W-54011 is a potent and orally active non-peptide **C5a receptor antagonist. W-54011 inhibits the binding of ¹²⁵I-labeled C5a to human neutrophils with a K_i value of 2.2 nM. W-54011 also inhibits C5a**-induced intracellular Ca ²⁺ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC₅₀s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively .

HY-110060

NDT 9513727	Complement System	Inflammation/Immunology
NDT 9513727 is a potent, selective, orally active and competitive inverse agonist of the human C5aR (C5a receptor), with an IC₅₀ of 11.6 nM. NDT 9513727 can be used for the research of human inflammatory diseases .

HY-148141

JPE-1375 4 Publications Verification	Complement System	Inflammation/Immunology
JPE-1375 is a *complement C5a* receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC₅₀=6.9 μM) and reduces TNF levels (EC₅₀**=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases .

HY-160901

CP-289,503	Complement System	Inflammation/Immunology
CP-289,503 is an inhibitor of the complement *C5a* receptor with an IC50 of 1 μM. C5a acts as an activator of leukocytes and phagocytes during complement system activation. The C5a receptor can bind to C5a, which can stimulate the upregulation of cell surface integrins and degranulation of inflammatory cells, leading to endothelial cell damage. C5a receptor inhibitors can block C5a signaling and inhibit a variety of inflammatory diseases .

HY-112199

CP-447697	Complement System	Inflammation/Immunology
CP-447697 is a lipophilic *C5a* receptor antagonist with an IC₅₀ value of 31 nM. CP-447697 can be used for the research of inflammation .

HY-177094

Izicopan INF056	Complement System	Inflammation/Immunology
Izicopan (INF056) is a complement factor C5a receptor antagonist. Izicopan inhibits C5a-induced calcium mobilization with an IC₅₀ of 10-100 nM .

HY-16384

L-156602 Antibiotic L 156602; PD 124966	Complement System	Inflammation/Immunology
L-156602 is a **C5a receptor** antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH) .

HY-W130878

4-Octylphenol	Complement System Toll-like Receptor (TLR) NF-κB	Inflammation/Immunology
4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the *C5a/C5aR1* axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (*Toll-like Receptor* (TLR))/IκBα/NF-κB** pathway .

HY-163379

C5aR1 antagonist 2	Complement System	Inflammation/Immunology
C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC₅₀ values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases .

HY-163378

C5aR1 antagonist 1	Complement System	Inflammation/Immunology
C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC₅₀ values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases .

HY-183414

C5aR antagonist-1	Complement System	Endocrinology
C5aR antagonist-1 is a potent C5aR antagonist with an IC₅₀ of < 5 nM. C5aR antagonist-1 is applicable to the research of crescentic and necrotizing glomerular lesions .

HY-180411

SM-15178	Leukotriene Receptor	Inflammation/Immunology
SM-15178 is a potent, orally active and selective leukotriene B₄ (LTB₄) receptor antagonist with an IC₅₀ of 0.30 μM. SM-15178 attenuates LTB₄ (HY-107608)-induced neutrophil accumulation in mouse skin and bronchoconstriction in guinea pigs. SM-15178 emonstrates significant anti-inflammatory efficacy across multiple animal models of inflammation. SM-15178 can be used for the research of chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, and asthma .

Cat. No.	Product Name	Target	Research Area

HY-106178

PMX-53 5+ Cited Publications 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active *complement C5a* receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1** and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-110136

PMX 205 10+ Cited Publications	Complement System	Inflammation/Immunology
PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.

HY-P5506

C5a Receptor agonist, W5Cha	Complement System	Others
C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement **C5a receptor (C5aR) agonist (EC₅₀=0.2 μM), a hexapeptide derived from the C-terminus of C5a** with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the **C5a receptor** through its C-terminal arginine, thereby activating the receptor .

HY-P5509

C5aR1 antagonist peptide	Peptides	Others
C5aR1 antagonist peptide is a biological active peptide. (This linear peptide is derived from the C-terminus of the chemokine, complement fragment 5 anaphylatoxin (C5a). This peptide functions to inhibit C5a binding and function at human and rat C5a receptors. C5a is crucial to triggering cellular immune responses and its overexpression is involved in arthritis, Alzheimer’s disease, cystic fibrosis, systemic lupus erythematosus, and other immunoinflammatory diseases.)

Cat. No.	Product Name	Target	Research Area	Image

HY-P99450

Avdoralimab IPH 5401; Anti-C5aR1 mAb	Complement System	Inflammation/Immunology Cancer
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the *complement C5a* receptor 1 (C5aR1)** that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700398

	C5AR1 Protein-VLP, Human (HEK293, His) complement component 5a receptor 1; C5R1, complement component 5 receptor 1 (C5a ligand); C5a anaphylatoxin chemotactic receptor; C5a; C5aR; CD88; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1; C5R1;	Human	HEK293
	C5AR1 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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