125228-51-5
Chemical Structure
L-156602
Synonym(s): Antibiotic L 156602; PD 124966
- CAS No.: 125228-51-5
- Formula:C38H64N8O13
- Molecular Weight:840.96
IUPAC Name: (S)-N-((4aS,7S,16aR,19R,22S,23S)-6,18-dihydroxy-22-isopropyl-7,19-dimethyl-5,8,11,17,20,24-hexaoxodocosahydro-13H,22H-dipyridazino[6,1-f:6',1'-o][1]oxa[4,7,10,13,16]pentaazacyclononadecin-23-yl)-2-hydroxy-2-((2R,5R,6R)-2-hydroxy-6-methyl-5-((S)-2-methylbutyl)tetrahydro-2H-pyran-2-yl)propanamide
InChIKey: ZJZOPNINWIGNQW-INBMEMTISA-N
SMILES: CC[C@@H](C[C@H]1CC[C@@]([C@@](C(N[C@H]2[C@H](C(C)C)OC([C@@H](C)N(O)C([C@H]3CCCNN3C(CNC([C@H](C)N(O)C([C@@H]4CCCNN4C2=O)=O)=O)=O)=O)=O)=O)(O)C)(O)O[C@@H]1C)C
Biological Activity: L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH)[1][2].
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L-156602 | L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH). | |||||||||||||||||||||
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References
- [1]. Tsuji RF, et al. Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation. Biosci Biotechnol Biochem. 1992 Dec;56(12):2034-6. [Content Brief]
- [2]. Tsuji RF, et al. Anti-inflammatory effects and specificity of L-156,602: comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response. Immunopharmacology. 1995 Feb;29(1):79-87. [Content Brief]
