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Cat. No.: HY-183414

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C5aR antagonist-1

C5aR antagonist-1 is a potent C5aR antagonist with an IC₅₀ of < 5 nM. C5aR antagonist-1 is applicable to the research of crescentic and necrotizing glomerular lesions.

For research use only. We do not sell to patients.

CAS No.: 1257868-45-3
Formula: C₃₃H₃₅F₄N₃O₂
Molecular Weight:581.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

C5aR antagonist-1 Chemical Structure

CAS No.: 1257868-45-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

C5aR antagonist-1 is a potent C5aR antagonist with an IC₅₀ of < 5 nM. C5aR antagonist-1 is applicable to the research of crescentic and necrotizing glomerular lesions^[1].

In Vitro

C5aR antagonist-1 (Compound 1.148) exhibits potent and highly selective antagonistic activity against C5aR in the ¹²⁵I-C5a competitive binding assay, with an IC₅₀ < 5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1257868-45-3
Molecular Weight 581.66
Formula C₃₃H₃₅F₄N₃O₂
SMILES

C(=O)(N1[C@H]([C@H](C(NC2=CC(C(F)(F)F)=C(C)C=C2)=O)CCC1)C3=CC=C(NC4CCCC4)C=C3)C5=C(C)C=CC=C5F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pingchen Fan, et al. C5ar antagonists. WO2011163640A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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