2. Immunology/Inflammation
  3. Complement System
  4. C5aR antagonist-1

C5aR antagonist-1 is a potent C5aR antagonist with an IC50 of < 5 nM. C5aR antagonist-1 is applicable to the research of crescentic and necrotizing glomerular lesions.

For research use only. We do not sell to patients.

C5aR antagonist-1

C5aR antagonist-1 Chemical Structure

CAS No. : 1257868-45-3

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C5aR antagonist-1 Related Antibodies

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Description

C5aR antagonist-1 is a potent C5aR antagonist with an IC50 of < 5 nM. C5aR antagonist-1 is applicable to the research of crescentic and necrotizing glomerular lesions[1].

In Vitro

C5aR antagonist-1 (Compound 1.148) exhibits potent and highly selective antagonistic activity against C5aR in the 125I-C5a competitive binding assay, with an IC50 < 5 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C5aR antagonist-1 Related Antibodies
Molecular Weight

581.66

Formula

C33H35F4N3O2
CAS No.
SMILES

C(=O)(N1[C@H]([C@H](C(NC2=CC(C(F)(F)F)=C(C)C=C2)=O)CCC1)C3=CC=C(NC4CCCC4)C=C3)C5=C(C)C=CC=C5F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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C5aR antagonist-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C5aR antagonist-11257868-45-3Complement Systemnecrotic glomerular lesionsC5a receptorcrescentic glomerular lesionsInhibitorinhibitorinhibit

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C5aR antagonist-1
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