Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
66 Results for "
CD4 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (66)
66 Results for "CD4 receptor" in MCE Product Catalog:
9
9 Publications Verification
Synonyms: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium
Target:
9
9 Publications Verification
Synonyms: c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium
Target:
7
BMS-378806 is a potent HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
6
6 Cited Publications
Target:
Research Areas:
AS2863619 is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 targets Stat5a-CDK8/19 to promote the differentiation of CD4 + T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 can be applied to research in related fields such as periodontitis-induced bone defects .
6
6 Cited Publications
Target:
Research Areas:
AS2863619 free base is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 free base targets Stat5a-CDK8/19 to promote the differentiation of CD4 + T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 free base also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 free base exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 free base can be applied to research in related fields such as periodontitis-induced bone defects .
1
1 Cited Publications
Cat. No.: HY-D0976
CAS No.: 202983-32-2
Target:
Research Areas:
NF279 is a selective P2X1 receptor antagonist and NTPDase inhibitor, with a P2X1 IC50 value of 19 nM. NF279 suppresses GABA-evoked currents, reduces ATP-excited respiratory activity, alters hypoglossal nerve burst parameters, and blocks CXCR4, CCR5, CXCR3, and CXCR7-mediated calcium responses. NF279 arrests HIV-1 fusion downstream of CD4 binding, inhibits R5- and X4-tropic HIV-1 strains. NF279 can be used for the research of HIV-1 infection .
1
1
1 Cited Publications
Target:
Research Areas:
(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4 + T cells into other lineages, including Th1 and regulatory T cells .
1
Target:
Research Areas:
Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4 +CD45RB high T cell-transferred mouse colitis model .
1
1 Cited Publications
Cat. No.: HY-P72904
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD4; CD4 receptor; CD4 Molecule; Surface Glycoprotein Variant; T-Cell Surface Glycoprotein CD4; CD4 Antigen; T-Cell Surface Antigen T4/Leu-3; CD4 Protein; Leu-3; CD4mut; T4; IMD79; CD4 Antigen (P55); OKT4D
Cat. No.: HY-P1745
CAS No.: 163364-16-7
Synonyms: Insulin B chain (9-23)
Target:
Research Areas:
Cat. No.: HY-P991069
CAS No.: 1412901-55-3
Cat. No.: HY-P99159
CAS No.: 2128729-41-7
Target:
Research Areas:
Cat. No.: HY-B0426A
CAS No.: 140462-76-6
Synonyms: ALO4943A; KW4679
Category:
Alkaloids Other Alkaloids Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-P1066
CAS No.: 217082-57-0
Target:
Research Areas:
Cat. No.: HY-P991336
CAS No.: 2708115-83-5
Synonyms: INBRX-106; ES-102
Target:
Research Areas:
Cat. No.: HY-107780
CAS No.: 61093-23-0
Synonyms: c-di-GMP; cyclic diguanylate; 5GP-5GP
Category:
Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-P99266
CAS No.: 652153-01-0
Synonyms: Anti-Human CD4 Recombinant Antibody
Target:
Research Areas:
Cat. No.: HY-P1064
CAS No.: 252642-12-9
Target:
Research Areas:
Cat. No.: HY-W062109
CAS No.: 113806-05-6
Category:
Alkaloids Other Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
