CPP32

By Targets:	Apoptosis (3) Casein Kinase (1) Caspase (5) Cathepsin (1) Glutathione Peroxidase (1) Histone Demethylase (1) PD-1/PD-L1 (1) Reactive Oxygen Species (ROS) (1) RIP kinase (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658B

Z-VAD-FMK 735+ Cited Publications Z-VAD(OH)-FMK	Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-156202

Geranylgeranoic acid	Histone Demethylase PD-1/PD-L1 Apoptosis	Cancer
Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC₅₀ value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis .

HY-RS01952

CASP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Caspase	Others
CASP3 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CASP3 Human Pre-designed siRNA Set A CASP3 Human Pre-designed siRNA Set A

HY-N14403

6-Hydroxytetrangulol	Cathepsin	Infection
6-Hydroxytetrangulol is a CPP32 protease inducer found in Streptomyces sp .

HY-P3234

Ac-ESMD-CHO	Casein Kinase	Others
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-P5936

Ac-AAVALLPAVLLALLAP-DEVD-CHO DEVD-CHO-CPP 32	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor .

HY-RS01953

Casp3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Caspase	Others
Casp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Casp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Casp3 Mouse Pre-designed siRNA Set A Casp3 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-16658BG

Z-VAD-FMK	Fluorescent Dye
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Z-VAD-FMK

Fluorescent Dye

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Cat. No.	Product Name	Type

HY-16658BG

Z-VAD-FMK	Biochemical Assay Reagents
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Z-VAD-FMK

Biochemical Assay Reagents

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Cat. No.	Product Name	Target	Research Area

HY-P3234

Ac-ESMD-CHO	Casein Kinase	Others
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .

HY-P5936

Ac-AAVALLPAVLLALLAP-DEVD-CHO DEVD-CHO-CPP 32	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N14403

6-Hydroxytetrangulol	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Cathepsin
6-Hydroxytetrangulol is a CPP32 protease inducer found in Streptomyces sp .

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P79267

	Pro-Caspase-3/Pro-CASP3 Protein, Human (277a.a, His) Caspase-3; CASP3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1; CPP32	Human	E. coli
	Pro-Caspase-3/Pro-CASP3 Protein, Human (277a.a, His) is the recombinant human-derived Caspase-3/CASP3, expressed by E. coli , with N-His labeled tag.

HY-P701341

	Caspase-3/CASP3 Protein, Human 5+ Cited Publications CASP3; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	Human	E. coli
	Caspase-3/CASP3 protein is a thiol protease critical in apoptosis and is activated by initiating caspases (CASP8, CASP9 and/or CASP10). It catalyzes the cleavage of multiple proteins in sympathetic neurons, including PARP1, SREBP, caspase-6, -7 and -9, huntingtin, and RET. Caspase-3/CASP3 Protein, Human is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli, with tag free.

HY-P72874

	Caspase-3/CASP3 Protein, Human (His) Caspase-3; CASP-3; CPP-32; SCA-1; YAMA	Human	E. coli
	Caspase-3/CASP3 protein is critical in the execution of apoptosis, cleaving PARP1 and activating SREBP, caspase-6, -7 and -9, initiating the cascade leading to apoptosis. In addition to apoptosis, it regulates cell adhesion, promotes inflammation, inhibits AKT1 in oxidative stress, and modulates antiviral responses by cleaving proteins such as CGAS, IRF3, and MAVS. Caspase-3/CASP3 Protein, Human (His) is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli , with C-His labeled tag.

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Host:	Mouse (4) Rabbit (5)
Reactivity:	Human (9) Rat (8) Mouse (8) Chicken (1)
Application:	IHC-P (5) ICC/IF (6) IP (3) WB (9) ELISA (4)
Isotype:	IgG (4) IgG1 (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (9)
Clonality:	Monoclonal (6) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84318

	Caspase-3 Antibody (YA4015) CPP32; SCA-1; CPP32B	WB, ELISA	Human, Mouse, Rat
	Caspase-3 Antibody (YA4015) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Caspase-3.

HY-P86633

	Caspase-3 Antibody (YA6325) CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Caspase-3 Antibody (YA6325) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-3.

HY-P85735

	Caspase-3 Antibody (YA5427) CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	ICC/IF, WB, IP, IHC-P	Human, Mouse, Rat, Chicken
	Caspase-3 Antibody (YA5427) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Caspase-3.

HY-P84318A

	Caspase-3 Antibody (YA4015)(PBS only) CPP32; SCA-1; CPP32B	WB, ELISA	Human, Mouse, Rat
	Caspase-3 Antibody (YA4015) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Caspase-3.

HY-P86370

	Cleaved Caspase-3 (Asp175) Antibody (YA6062) 2 Publications Verification CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Cleaved Caspase-3 (Asp175) Antibody (YA6062) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cleaved Caspase-3 (Asp175).

HY-P84931

	Cleaved-Caspase 3 p17 Antibody (YA4628) CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	WB, IHC-P, ICC/IF	Human
	Cleaved-Caspase 3 p17 Antibody (YA4628) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cleaved-Caspase 3.

HY-P80623

	Cleaved-Caspase 3 p12 Antibody (YA499) 5+ Cited Publications CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	WB, ICC/IF	Human, Mouse, Rat
	Cleaved-Caspase 3 Antibody (YA499) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cleaved-Caspase 3.

HY-P80623A

	Cleaved-Caspase 3 p12 Antibody (YA499)(PBS only) CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	WB, ICC/IF	Human, Mouse, Rat
	Cleaved-Caspase 3 Antibody (YA499) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cleaved-Caspase 3.

HY-P85695

	TGF beta Antibody (YA5387) Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1; [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	IHC-P, WB	Human, Mouse, Rat
	TGF beta Antibody (YA5387) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TGF beta.

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Products	In-stock - + Add to Cart
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS01952

CASP3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CASP3 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01953

Casp3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Casp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Casp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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Fluorescent Dye

Biochemical Assay Reagents

Peptides

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Recombinant Proteins

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Oligonucleotides

GMP Molecules

CPP32

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

GMP Molecules

Natural
Products