191338-87-1
191338-87-1
Chemical Structure
Ac-ESMD-CHO
- CAS No.: 191338-87-1
- Formula:C19H30N4O10S
- Molecular Weight:506.53
InChIKey: TVTYMGFOGZRIHG-XUXIUFHCSA-N
SMILES: OC(C[C@@H](C=O)NC([C@H](CCSC)NC([C@H](CO)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O
Biological Activity: Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].
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Ac-ESMD-CHO | Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site. | |||||||||||||||||||||
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References
- [1]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. [Content Brief]
- [2]. Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65. [Content Brief]
Keywords
