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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
CRD
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "CRD" in MCE Product Catalog:
10
10 Publications Verification
Synonyms: CRD-401
Target:
Research Areas:
Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist).
5
5 Cited Publications
Synonyms: 20α-Hydroxycholesterol
Target:
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(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.
Cat. No.: HY-146081
CAS No.: 2493080-27-4
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Research Areas:
CD22 ligand-1 is a CD22-selective ligand with a Kd value of 0.335 μM for human CD22. CD22 ligand-1 binds to CD22 with high affinity and can be used for drug conjugation to achieve B cell targeting or multimer formation. CD22 ligand-1 is applicable to the study of B cell-mediated autoimmune diseases and B cell-associated lymphomas .
Cat. No.: HY-14656S3
CAS No.: 2012598-70-6
Synonyms: CRD-401-d5 hydrochloride
Cat. No.: HY-P991510
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Research Areas:
Cat. No.: HY-14656S2
CAS No.: 1309283-34-8
Synonyms: CRD-401-d6 hydrochloride
Cat. No.: HY-133974
CAS No.: 64907-23-9
Synonyms: 7-keto-25-OHC
7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo .
Cat. No.: HY-14656R
CAS No.: 33286-22-5
Synonyms: CRD-401 (Standard)
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Research Areas:
Diltiazem (hydrochloride) (Standard) is the analytical standard of Diltiazem (hydrochloride). This product is intended for research and analytical applications. Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist).
Cat. No.: HY-RS03203
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Research Areas:
CRX Human Pre-designed siRNA Set A contains three designed siRNAs for CRX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-162372
CAS No.: 2916444-33-0
Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization .
Cat. No.: HY-RS12154
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Research Areas:
RPGR Human Pre-designed siRNA Set A contains three designed siRNAs for RPGR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-14656S4
CAS No.: 2699608-24-5
Synonyms: CRD-401-d4-1
Cat. No.: HY-W069974
CAS No.: 79932-56-2
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Research Areas:
Ca2+-Langerin-IN-1 (Compound 3) is a allosteric Langerin inhibitor. Langerin is a C-type lectin that is expressed on Langerhans cells and plays a crucial role in pathogen recognition and innate immune activation. The KD value of the CRD domain of murine Langerin protein for Ca2+-Langerin-IN-1 is 17 μM under the presence of Ca²⁺ and 53 μM under the absence of Ca²⁺ competition. Ca2+-Langerin-IN-1 induces conformational changes and competitively replaces Ca²⁺, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+-Langerin-IN-1 can be used in the research of immunomodulatory therapy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
