4 Results for "

Cariprazine-d8

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Cariprazine-d8" in MCE Product Catalog:

Cariprazine-d8
Cariprazine-d8
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Cat. No.: HY-14763S1
CAS No.: 1308278-50-3
Purity:  99.51%
Synonyms: RGH-188 d8
Cariprazine-d8 is a deuterium labeled Cariprazine. Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
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Desmethyl cariprazine-d8
Desmethyl cariprazine-d8
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Cat. No.: HY-100656AS
CAS No.: 1308278-85-4
Desmethyl cariprazine-d8 is the deuterium labeled Desmethyl cariprazine (HY-100656). Desmethyl cariprazine is a major active metabolite of cariprazine, with activities at human dopamine receptors and serotonin receptors, showing a pEC50 of 8.90 at human D2 receptors, a pEC50 of 8.09 at D3 receptors, and a pEC50 of 6.28 at 5-HT1A receptors. Desmethyl cariprazine inhibits forskolin-induced cAMP production at D2, D3 and 5-HT1A receptors, and suppresses serotonin-induced Ca 2+ release at 5-HT2B receptors. Desmethyl cariprazine is applicable to research related to schizophrenia, bipolar disorder type I and bipolar disorder.
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Didesmethyl cariprazine-d8
Didesmethyl cariprazine-d8
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Cat. No.: HY-100658S
CAS No.: 1308279-08-4
Didesmethyl cariprazine-d8 is the deuterium labeled Didesmethyl cariprazine (HY-100658). Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine (HY-14763). Didesmethyl cariprazine is a partial agonist at the D2 and D3 receptors, full agonist at the 5-HT1A receptor, and antagonist at the human 5-HT2B receptor (Ki: 1.41 nM (human D2L), 0.056 nM (human D3), 1.7 nM (human 5-HT1A), 0.52 nM (human 5-HT2B)). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons.
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Cariprazine-d8-1
Cariprazine-d8-1
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Cat. No.: HY-W716520
CAS No.: 1308278-69-4
Synonyms: RGH-188-d8
Cariprazine-d8-1 (RGH-188-d8-1) is the deuterium labeled Cariprazine (HY-14763). Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
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